Next Article in Journal
Antibody Phage Display Libraries: Contributions to Oncology
Previous Article in Journal
The Role of Protein Crystallography in Defining the Mechanisms of Biogenesis and Catalysis in Copper Amine Oxidase
Int. J. Mol. Sci. 2012, 13(5), 5406-5419; doi:10.3390/ijms13055406

In Vitro Phytotoxicity and Antioxidant Activity of Selected Flavonoids

1 Dipartimento di Scienze Farmaceutiche e Biomediche, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Salerno, Italy 2 Departamento de Botânica, Instituto de Biociências de Botucatu, UNESP-Campu de Botucatu Distrito de Rubião Júnior, S/N, 18.618-000, Botucatu-SP, Brazil
* Author to whom correspondence should be addressed.
Received: 19 March 2012 / Revised: 24 April 2012 / Accepted: 28 April 2012 / Published: 4 May 2012
View Full-Text   |   Download PDF [224 KB, uploaded 19 June 2014]   |   Browse Figures


The knowledge of flavonoids involved in plant-plant interactions and their mechanisms of action are poor and, moreover, the structural characteristics required for these biological activities are scarcely known. The objective of this work was to study the possible in vitro phytotoxic effects of 27 flavonoids on the germination and early radical growth of Raphanus sativus L. and Lepidium sativum L., with the aim to evaluate the possible structure/activity relationship. Moreover, the antioxidant activity of the same compounds was also evaluated. Generally, in response to various tested flavonoids, germination was only slightly affected, whereas significant differences were observed in the activity of the various tested flavonoids against radical elongation. DPPH test confirms the antioxidant activity of luteolin, quercetin, catechol, morin, and catechin. The biological activity recorded is discussed in relation to the structure of compounds and their capability to interact with cell structures and physiology. No correlation was found between phytotoxic and antioxidant activities.
Keywords: flavonoids; germination; radical elongation; antioxidant activity; structure/activity flavonoids; germination; radical elongation; antioxidant activity; structure/activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

De Martino, L.; Mencherini, T.; Mancini, E.; Aquino, R.P.; De Almeida, L.F.R.; De Feo, V. In Vitro Phytotoxicity and Antioxidant Activity of Selected Flavonoids. Int. J. Mol. Sci. 2012, 13, 5406-5419.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert