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Int. J. Mol. Sci. 2012, 13(4), 5010-5018; doi:10.3390/ijms13045010
Article

Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities

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Received: 7 March 2012; in revised form: 27 March 2012 / Accepted: 12 April 2012 / Published: 20 April 2012
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Abstract: A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC50 values of 1.68 and 1.32 μM, respectively.
Keywords: Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nayyatip, S.; Thaichana, P.; Buayairaksa, M.; Tuntiwechapikul, W.; Meepowpan, P.; Nuntasaen, N.; Pompimon, W. Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities. Int. J. Mol. Sci. 2012, 13, 5010-5018.

AMA Style

Nayyatip S, Thaichana P, Buayairaksa M, Tuntiwechapikul W, Meepowpan P, Nuntasaen N, Pompimon W. Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities. International Journal of Molecular Sciences. 2012; 13(4):5010-5018.

Chicago/Turabian Style

Nayyatip, Sanchai; Thaichana, Pak; Buayairaksa, Mongkol; Tuntiwechapikul, Wirote; Meepowpan, Puttinan; Nuntasaen, Narong; Pompimon, Wilart. 2012. "Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities." Int. J. Mol. Sci. 13, no. 4: 5010-5018.


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