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Int. J. Mol. Sci. 2012, 13(4), 5010-5018; doi:10.3390/ijms13045010

Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities

1
Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand
2
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 53000, Thailand
3
Department of Chemistry, Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 53000, Thailand
4
The Forest Herbarium, Department of National Park, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, Bangkok 10220, Thailand
*
Author to whom correspondence should be addressed.
Received: 7 March 2012 / Revised: 27 March 2012 / Accepted: 12 April 2012 / Published: 20 April 2012
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Abstract

A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC50 values of 1.68 and 1.32 μM, respectively. View Full-Text
Keywords: Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nayyatip, S.; Thaichana, P.; Buayairaksa, M.; Tuntiwechapikul, W.; Meepowpan, P.; Nuntasaen, N.; Pompimon, W. Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities. Int. J. Mol. Sci. 2012, 13, 5010-5018.

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