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Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities
Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 53000, Thailand
Department of Chemistry, Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 53000, Thailand
The Forest Herbarium, Department of National Park, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, Bangkok 10220, Thailand
* Author to whom correspondence should be addressed.
Received: 7 March 2012; in revised form: 27 March 2012 / Accepted: 12 April 2012 / Published: 20 April 2012
Abstract: A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC50 values of 1.68 and 1.32 μM, respectively.
Keywords: Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities
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Nayyatip, S.; Thaichana, P.; Buayairaksa, M.; Tuntiwechapikul, W.; Meepowpan, P.; Nuntasaen, N.; Pompimon, W. Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities. Int. J. Mol. Sci. 2012, 13, 5010-5018.
Nayyatip S, Thaichana P, Buayairaksa M, Tuntiwechapikul W, Meepowpan P, Nuntasaen N, Pompimon W. Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities. International Journal of Molecular Sciences. 2012; 13(4):5010-5018.
Nayyatip, Sanchai; Thaichana, Pak; Buayairaksa, Mongkol; Tuntiwechapikul, Wirote; Meepowpan, Puttinan; Nuntasaen, Narong; Pompimon, Wilart. 2012. "Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities." Int. J. Mol. Sci. 13, no. 4: 5010-5018.