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Int. J. Mol. Sci. 2012, 13(4), 5010-5018; doi:10.3390/ijms13045010
Article

Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities

1
, 2
, 1
, 2
, 3
, 4
 and 1,*
1 Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand 2 Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 53000, Thailand 3 Department of Chemistry, Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 53000, Thailand 4 The Forest Herbarium, Department of National Park, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, Bangkok 10220, Thailand
* Author to whom correspondence should be addressed.
Received: 7 March 2012 / Revised: 27 March 2012 / Accepted: 12 April 2012 / Published: 20 April 2012
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Abstract

A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC50 values of 1.68 and 1.32 μM, respectively.
Keywords: Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nayyatip, S.; Thaichana, P.; Buayairaksa, M.; Tuntiwechapikul, W.; Meepowpan, P.; Nuntasaen, N.; Pompimon, W. Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities. Int. J. Mol. Sci. 2012, 13, 5010-5018.

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