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Int. J. Mol. Sci. 2012, 13(4), 4982-4992; doi:10.3390/ijms13044982
Article

Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes

1,2
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1,2
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1
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3,*  and 1,*
1 Department of Chemistry, Kakatiya University, Warangal 506 009, A.P, India 2 Department of Chemistry, National Dong Hwa University, Hualien 974, Taiwan 3 Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien 97004, Taiwan
* Authors to whom correspondence should be addressed.
Received: 8 March 2012 / Revised: 11 April 2012 / Accepted: 12 April 2012 / Published: 19 April 2012
(This article belongs to the Section Material Sciences and Nanotechnology)
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Abstract

A novel family of tetraaza macrocyclic Cu(II) complexes [CuLX2] (where L = N4 donor macrocyclic ligands) and (X = Cl, NO3) have been synthesized and characterized by elemental analysis, magnetic moments, IR, EPR, mass, electronic spectra and thermal studies. The magnetic moments and electronic spectral studies suggest square planar geometry for [Cu(DBACDT)]Cl2 and [Cu(DBACDT)](NO3)2 complexes and distorted octahedral geometry to the rest of the ten complexes. The biological activity of all these complexes against gram-positive and gram-negative bacteria was compared with the activity of existing commercial antibacterial compounds like Linezolid and Cefaclor. Six complexes out of twelve were found to be most potent against both gram-positive as well as gram-negative bacteria due to the presence of thio group in the coordinated ligands.
Keywords: synthesis; antibacterial studies; tetraaza macrocycles; copper(II) complexes synthesis; antibacterial studies; tetraaza macrocycles; copper(II) complexes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Reddy, P.M.; Rohini, R.; Krishna, E.R.; Hu, A.; Ravinder, V. Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes. Int. J. Mol. Sci. 2012, 13, 4982-4992.

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