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Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes
Department of Chemistry, Kakatiya University, Warangal 506 009, A.P, India
Department of Chemistry, National Dong Hwa University, Hualien 974, Taiwan
Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien 97004, Taiwan
* Authors to whom correspondence should be addressed.
Received: 8 March 2012; in revised form: 11 April 2012 / Accepted: 12 April 2012 / Published: 19 April 2012
Abstract: A novel family of tetraaza macrocyclic Cu(II) complexes [CuLX2] (where L = N4 donor macrocyclic ligands) and (X = Cl−, NO3−) have been synthesized and characterized by elemental analysis, magnetic moments, IR, EPR, mass, electronic spectra and thermal studies. The magnetic moments and electronic spectral studies suggest square planar geometry for [Cu(DBACDT)]Cl2 and [Cu(DBACDT)](NO3)2 complexes and distorted octahedral geometry to the rest of the ten complexes. The biological activity of all these complexes against gram-positive and gram-negative bacteria was compared with the activity of existing commercial antibacterial compounds like Linezolid and Cefaclor. Six complexes out of twelve were found to be most potent against both gram-positive as well as gram-negative bacteria due to the presence of thio group in the coordinated ligands.
Keywords: synthesis; antibacterial studies; tetraaza macrocycles; copper(II) complexes
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Reddy, P.M.; Rohini, R.; Krishna, E.R.; Hu, A.; Ravinder, V. Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes. Int. J. Mol. Sci. 2012, 13, 4982-4992.
Reddy PM, Rohini R, Krishna ER, Hu A, Ravinder V. Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes. International Journal of Molecular Sciences. 2012; 13(4):4982-4992.
Reddy, Puchakayala Muralidhar; Rohini, Rondla; Krishna, Edulla Ravi; Hu, Anren; Ravinder, Vadde. 2012. "Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes." Int. J. Mol. Sci. 13, no. 4: 4982-4992.