Abstract: A novel family of tetraaza macrocyclic Cu(II) complexes [CuLX2] (where L = N4 donor macrocyclic ligands) and (X = Cl−, NO3−) have been synthesized and characterized by elemental analysis, magnetic moments, IR, EPR, mass, electronic spectra and thermal studies. The magnetic moments and electronic spectral studies suggest square planar geometry for [Cu(DBACDT)]Cl2 and [Cu(DBACDT)](NO3)2 complexes and distorted octahedral geometry to the rest of the ten complexes. The biological activity of all these complexes against gram-positive and gram-negative bacteria was compared with the activity of existing commercial antibacterial compounds like Linezolid and Cefaclor. Six complexes out of twelve were found to be most potent against both gram-positive as well as gram-negative bacteria due to the presence of thio group in the coordinated ligands.
Keywords: synthesis; antibacterial studies; tetraaza macrocycles; copper(II) complexes
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Reddy, P.M.; Rohini, R.; Krishna, E.R.; Hu, A.; Ravinder, V. Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes. Int. J. Mol. Sci. 2012, 13, 4982-4992.
Reddy PM, Rohini R, Krishna ER, Hu A, Ravinder V. Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes. International Journal of Molecular Sciences. 2012; 13(4):4982-4992.
Reddy, Puchakayala Muralidhar; Rohini, Rondla; Krishna, Edulla Ravi; Hu, Anren; Ravinder, Vadde. 2012. "Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes." Int. J. Mol. Sci. 13, no. 4: 4982-4992.