Cell Adhesion and Its Endocytic Regulation in Cell Migration during Neural Development and Cancer Metastasis
Abstract
:1. Introduction
2. Structures and Functions of Cell Adhesion Complexes
2.1. Adherens Junctions
2.2. Desmosomes
2.3. Tight Junctions and Gap Junctions
2.4. Focal Adhesions
3. Intracellular Trafficking Pathways
4. Cadherin Endocytosis and Epithelial-to-Mesenchymal Transition
5. Integrin Endocytosis and Cell Migration
6. Roles of Cell Adhesion Dynamics in Cancer
6.1. Cancer Metastasis
6.2. EMT in Cancer
6.3. Collective Invasion
6.4. Amoeboid Migration
7. Endocytic Regulation of Cell Adhesion in Neural Development
7.1. Cell Adhesion and Cerebral Cortical Development
7.2. Scaffold Cell-Dependent Migration in Neural Development
8. Conclusion Remarks
Acknowledgments
References
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Integrin subunits | Major Ligands | |
---|---|---|
α1 | β1 | Collagen, Laminin |
α2 | β1 | Collagen, Laminin, Tenascin, |
α3 | β1 | Laminin, Collagen |
α4 | β1 | Fibronectin, VCAM-1 |
β7 | MAdCAM-1, Fibronectin | |
α5 | β1 | Fibronectin |
α6 | β1 | Laminin |
β4 | Laminin | |
α7 | β1 | Laminin |
α8 | β1 | Fibronectin, Tenascin |
α9 | β1 | Tenascin |
α10 | β1 | Collagen |
α11 | β1 | Collagen |
αIIb | β3 | Fibronectin, Vitronectin, Fibrinogen |
αv | β1 | Vitronectin, Fibronectin |
β3 | Vitronectin, Fibronectin, Fibrinogen | |
β5 | Vitronectin | |
β6 | Fibronectin, Tenascin | |
β8 | Vitronectin | |
αL | β2 | ICAM-1, −2, −3 |
αM | β2 | Fibrinogen, iC3b |
αX | β2 | Fibrinogen, iC3b |
αD | β2 | ICAM-3, VCAM-1 |
αE | β7 | E-cadherin |
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Kawauchi, T. Cell Adhesion and Its Endocytic Regulation in Cell Migration during Neural Development and Cancer Metastasis. Int. J. Mol. Sci. 2012, 13, 4564-4590. https://doi.org/10.3390/ijms13044564
Kawauchi T. Cell Adhesion and Its Endocytic Regulation in Cell Migration during Neural Development and Cancer Metastasis. International Journal of Molecular Sciences. 2012; 13(4):4564-4590. https://doi.org/10.3390/ijms13044564
Chicago/Turabian StyleKawauchi, Takeshi. 2012. "Cell Adhesion and Its Endocytic Regulation in Cell Migration during Neural Development and Cancer Metastasis" International Journal of Molecular Sciences 13, no. 4: 4564-4590. https://doi.org/10.3390/ijms13044564