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Int. J. Mol. Sci. 2012, 13(2), 2036-2047; doi:10.3390/ijms13022036
Article

Influence of Post-Treatment with 75% (v/v) Ethanol Vapor on the Properties of SF/P(LLA-CL) Nanofibrous Scaffolds

* ,
 and
College of Materials and Textile Engineering, Jiaxing University, Zhejiang 314001, China
* Author to whom correspondence should be addressed.
Received: 10 January 2012 / Revised: 31 January 2012 / Accepted: 2 February 2012 / Published: 14 February 2012
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Abstract

In order to improve the water-resistant ability of silk fibroin (SF) and SF/P(LLA-CL) blended nanofibrous scaffolds for tissue engineering applications, 75% (v/v) ethanol vapor was used to post-treat electrospun nanofibers. SEM indicated that the treated SF and SF/ P(LLA-CL) nanofibrous scaffolds maintained a nanofibrous structure and possessed good water-resistant ability. Characterization of 13C CP-MAS NMR clarified that 75% (v/v) ethanol vapor could induce SF conformation from random coil or α-helix to β-sheet. Although the water contact showed that treated SF/P(LLA-CL) blended nanofibrous scaffolds were hydrophobic, the water uptake demonstrated that their hydrophilicity was greatly superior to those of pure P(LLA-CL) nanofibrous scaffolds. Furthermore, the treated SF/P(LLA-CL) nanofibrous scaffolds, both in dry state and wet state, could retain good mechanical properties. Therefore, 75% (v/v) ethanol vapor treatment might be an ideal method to treat SF and SF/P(LLA-CL) nanofibrous scaffolds for biomedical applications.
Keywords: electrospinning; SF/P(LLA-CL); post-treatment electrospinning; SF/P(LLA-CL); post-treatment
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zhang, K.-H.; Ye, Q.; Yan, Z.-Y. Influence of Post-Treatment with 75% (v/v) Ethanol Vapor on the Properties of SF/P(LLA-CL) Nanofibrous Scaffolds. Int. J. Mol. Sci. 2012, 13, 2036-2047.

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