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• Ali, H
• Abdulla, M
• Abdelwahab, S
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• Abdulla, M
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• Ali, H
• Abdulla, M
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Int. J. Mol. Sci. 2012, 13(2), 1393-1404; doi:10.3390/ijms13021393

Article

Acute Oral Toxicity Evaluations of Some Zinc(II) Complexes Derived from 1-(2-Salicylaldiminoethyl)piperazine Schiff Bases in Rats

Muhammad Saleh Salga ^1,* , Hapipah Mohd Ali ¹ , Mahmood Ameen Abdulla ²  and Siddig Ibrahim Abdelwahab ³

¹ Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia ² Department of Molecular Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia ³ Department of Pharmacy, University of Malaya, Kuala Lumpur 50603, Malaysia

* Author to whom correspondence should be addressed.

Received: 22 December 2011; in revised form: 12 January 2012 / Accepted: 13 January 2012 / Published: 27 January 2012

(This article belongs to the Section Green Chemistry)

Download PDF Full-Text [268 KB, uploaded 27 January 2012 17:14 CET]

Abstract: The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, ¹H NMR, ¹³C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not significantly change. The hematological indices white blood cells (WBC), haematocrit (HCT), red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) were within the normal range. The renal function indices examined were also within the reference range. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies.

Keywords: characterizations; acute toxicity; zinc complexes

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