Next Article in Journal
Preliminary Study of Conformation and Drug Release Mechanism of Doxorubicin-Conjugated Glycol Chitosan, via cis-Aconityl Linkage, by Molecular Modeling
Next Article in Special Issue
Geometrical Conditions Indispensable for Muscle Contraction
Previous Article in Journal
The Composition and Organization of Cytoplasm in Prebiotic Cells
Previous Article in Special Issue
Large-scale Models Reveal the Two-component Mechanics of Striated Muscle
Int. J. Mol. Sci. 2011, 12(3), 1660-1671; doi:10.3390/ijms12031660

The Role of Alpha-Dystrobrevin in Striated Muscle

1 Department of Neurology, Osaka University Graduate School of Medicine, 2-2, D-4, Yamadaoka, Suita, Osaka 565-0871, Japan 2 Department of Neurology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645 URMC, Rochester, NY 14642, USA
* Author to whom correspondence should be addressed.
Received: 16 December 2010 / Revised: 29 January 2011 / Accepted: 23 February 2011 / Published: 4 March 2011
(This article belongs to the Special Issue Advances in Muscle Contraction Studies)
View Full-Text   |   Download PDF [329 KB, uploaded 19 June 2014]   |   Browse Figures


Muscular dystrophies are a group of diseases that primarily affect striated muscle and are characterized by the progressive loss of muscle strength and integrity. Major forms of muscular dystrophies are caused by the abnormalities of the dystrophin glycoprotein complex (DGC) that plays crucial roles as a structural unit and scaffolds for signaling molecules at the sarcolemma. α-Dystrobrevin is a component of the DGC and directly associates with dystrophin. α-Dystrobrevin also binds to intermediate filaments as well as syntrophin, a modular adaptor protein thought to be involved in signaling. Although no muscular dystrophy has been associated within mutations of the α-dystrobrevin gene, emerging findings suggest potential significance of α-dystrobrevin in striated muscle. This review addresses the functional role of α-dystrobrevin in muscle as well as its possible implication for muscular dystrophy.
Keywords: dystrobrevin; syntrophin; dystrophin; DGC; muscular dystrophy; signaling; intermediate filament; splicing dystrobrevin; syntrophin; dystrophin; DGC; muscular dystrophy; signaling; intermediate filament; splicing
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Nakamori, M.; Takahashi, M.P. The Role of Alpha-Dystrobrevin in Striated Muscle. Int. J. Mol. Sci. 2011, 12, 1660-1671.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert