Int. J. Mol. Sci. 2010, 11(10), 4106-4113; doi:10.3390/ijms11104106
Article

Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of Osteoarthritis

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Received: 13 September 2010; Accepted: 15 October 2010 / Published: 21 October 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Introduction: Osteoarthritis is the most common form of arthritis. It is a slowly progressive joint disease typically seen in middle-age to elderly people. Intra-articular injection of hyaluronic acid is a well-documented treatment for knee osteoarthritis. Celebrex® (celecoxib) is a novel nonsteroidal anti-inflammatory drug, which could help to reduce inflammation and to reduce pain. The aim of this study was to evaluate the effects of intra-articular injection of celecoxib in a rabbit osteoarthritis model. Methods: Thirty New Zealand white rabbits underwent unilateral knee joint surgery using the Hulth technique. Six weeks post-surgery, the animals were randomly divided into three groups, and each group was respectively given weekly intra-articular injections with Celebrex®, hyaluronic acid and saline. On the sixth week, the results were assessed in rabbit models by gross observation, histological evaluation, and expression of IL-1β, TNF-α, MMP-3. Results: In the group given Celebrex® and hyaluronic acid, the pathological changes in the rabbit articular cartilage improved significantly, much more than in the saline group. The statistically significant suppression of IL-1β, TNF-α, MMP-3 was shown in the Celebrex group. No significant differences were detected between two treatment groups. Conclusions: Intra-articular injection of celecoxib is beneficial for knee osteoarthritis. It might repair and protect early osteoarthritis cartilage by delaying cartilage degeneration and impairing the function of inflammatory mediators, therefore, intra-articular injection of celecoxib can be used as an alternative to the current treatment of osteoarthritis.
Keywords: celecoxib; hyaluronic acid; intra-articular injection; osteoarthritis
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MDPI and ACS Style

Jiang, D.; Zou, J.; Huang, L.; Shi, Q.; Zhu, X.; Wang, G.; Yang, H. Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of Osteoarthritis. Int. J. Mol. Sci. 2010, 11, 4106-4113.

AMA Style

Jiang D, Zou J, Huang L, Shi Q, Zhu X, Wang G, Yang H. Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of Osteoarthritis. International Journal of Molecular Sciences. 2010; 11(10):4106-4113.

Chicago/Turabian Style

Jiang, Dinghua; Zou, Jun; Huang, Lixin; Shi, Qin; Zhu, Xuesong; Wang, Genlin; Yang, Huilin. 2010. "Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of Osteoarthritis." Int. J. Mol. Sci. 11, no. 10: 4106-4113.

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