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Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of Osteoarthritis
Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, 188 Shizi St., Suzhou, Jiangsu 215006, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 13 September 2010; Accepted: 15 October 2010 / Published: 21 October 2010
Abstract: Introduction: Osteoarthritis is the most common form of arthritis. It is a slowly progressive joint disease typically seen in middle-age to elderly people. Intra-articular injection of hyaluronic acid is a well-documented treatment for knee osteoarthritis. Celebrex® (celecoxib) is a novel nonsteroidal anti-inflammatory drug, which could help to reduce inflammation and to reduce pain. The aim of this study was to evaluate the effects of intra-articular injection of celecoxib in a rabbit osteoarthritis model. Methods: Thirty New Zealand white rabbits underwent unilateral knee joint surgery using the Hulth technique. Six weeks post-surgery, the animals were randomly divided into three groups, and each group was respectively given weekly intra-articular injections with Celebrex®, hyaluronic acid and saline. On the sixth week, the results were assessed in rabbit models by gross observation, histological evaluation, and expression of IL-1β, TNF-α, MMP-3. Results: In the group given Celebrex® and hyaluronic acid, the pathological changes in the rabbit articular cartilage improved significantly, much more than in the saline group. The statistically significant suppression of IL-1β, TNF-α, MMP-3 was shown in the Celebrex group. No significant differences were detected between two treatment groups. Conclusions: Intra-articular injection of celecoxib is beneficial for knee osteoarthritis. It might repair and protect early osteoarthritis cartilage by delaying cartilage degeneration and impairing the function of inflammatory mediators, therefore, intra-articular injection of celecoxib can be used as an alternative to the current treatment of osteoarthritis.
Keywords: celecoxib; hyaluronic acid; intra-articular injection; osteoarthritis
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Jiang, D.; Zou, J.; Huang, L.; Shi, Q.; Zhu, X.; Wang, G.; Yang, H. Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of Osteoarthritis. Int. J. Mol. Sci. 2010, 11, 4106-4113.
Jiang D, Zou J, Huang L, Shi Q, Zhu X, Wang G, Yang H. Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of Osteoarthritis. International Journal of Molecular Sciences. 2010; 11(10):4106-4113.
Jiang, Dinghua; Zou, Jun; Huang, Lixin; Shi, Qin; Zhu, Xuesong; Wang, Genlin; Yang, Huilin. 2010. "Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of Osteoarthritis." Int. J. Mol. Sci. 11, no. 10: 4106-4113.