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Int. J. Mol. Sci. 2009, 10(5), 2348-2366; doi:10.3390/ijms10052348

Microscopic Investigation of Reversible Nanoscale Surface Size Dependent Protein Conjugation

1
Department of Chemistry, The State University of New York at Geneseo, 1 College Circle, Geneseo, NY 14454, USA
2
Department of Biology, The State University of New York at Geneseo, 1 College Circle, Geneseo, NY 14454, USA
3
College of Nanoscale Science and Engineering, University of Albany-SUNY, 255 Fuller Road, Albany, NY 12203, USA
*
Author to whom correspondence should be addressed.
Received: 3 April 2009 / Revised: 14 May 2009 / Accepted: 18 May 2009 / Published: 20 May 2009
(This article belongs to the Special Issue Bioactive Nanoparticles (special issue))
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Abstract

1-40 coated 20 nm gold colloidal nanoparticles exhibit a reversible color change as pH is externally altered between pH 4 and 10. This reversible process may contain important information on the initial reversible step reported for the fibrillogenesis of Aβ (a hallmark of Alzheimer’s disease). We examined this reversible color change by microscopic investigations. AFM images on graphite surfaces revealed the morphology of Aβ aggregates with gold colloids. TEM images clearly demonstrate the correspondence between spectroscopic features and conformational changes of the gold colloid. View Full-Text
Keywords: amyloid beta; fibrillogenesis; Alzheimer’s disease; ovalbumin; gold nanoparticles; AFM; TEM amyloid beta; fibrillogenesis; Alzheimer’s disease; ovalbumin; gold nanoparticles; AFM; TEM
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MDPI and ACS Style

Yokoyama, K.; Cho, H.; Cullen, S.P.; Kowalik, M.; Briglio, N.M.; Hoops, H.J.; Zhao, Z.; Carpenter, M.A. Microscopic Investigation of Reversible Nanoscale Surface Size Dependent Protein Conjugation. Int. J. Mol. Sci. 2009, 10, 2348-2366.

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