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Int. J. Mol. Sci. 2009, 10(3), 1290-1299; doi:10.3390/ijms10031290

Origin of Homochirality in Biosystems

DNRF center “Glass and Time”, Roskilde University, Postbox 260 DK-4000 Roskilde, Denmark;
Received: 12 January 2009 / Revised: 12 March 2009 / Accepted: 18 March 2009 / Published: 18 March 2009
(This article belongs to the Special Issue Origin of Life)
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Experimental data for a series of central and simple molecules in biosystems show that some amino acids and a simple sugar molecule have a chiral discrimination in favor of homochirality. Models for segregation of racemic mixtures of chiral amphiphiles and lipophiles in aqueous solutions show that the amphiphiles with an active isomerization kinetics can perform a spontaneous break of symmetry during the segregation and self-assembly to homochiral matter. Based on this observation it is argued that biomolecules with a sufficiently strong chiral discrimination could be the origin of homochirality in biological systems.
Keywords: Origin of chirality; Origin of Life; Prebiotic self-assambly Origin of chirality; Origin of Life; Prebiotic self-assambly
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Toxvaerd, S. Origin of Homochirality in Biosystems. Int. J. Mol. Sci. 2009, 10, 1290-1299.

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