Next Article in Journal
In Vitro Models in Biocompatibility Assessment for Biomedical-Grade Chitosan Derivatives in Wound Management
Next Article in Special Issue
Molecules, Water, and Radiant Energy: New Clues for the Origin of Life
Previous Article in Journal
Explaining Ionic Liquid Water Solubility in Terms of Cation and Anion Hydrophobicity
Previous Article in Special Issue
Model Protocells from Single-Chain Lipids
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2009, 10(3), 1290-1299; doi:10.3390/ijms10031290

Origin of Homochirality in Biosystems

DNRF center “Glass and Time”, Roskilde University, Postbox 260 DK-4000 Roskilde, Denmark;
Received: 12 January 2009 / Revised: 12 March 2009 / Accepted: 18 March 2009 / Published: 18 March 2009
(This article belongs to the Special Issue Origin of Life)
View Full-Text   |   Download PDF [187 KB, uploaded 19 June 2014]   |  


Experimental data for a series of central and simple molecules in biosystems show that some amino acids and a simple sugar molecule have a chiral discrimination in favor of homochirality. Models for segregation of racemic mixtures of chiral amphiphiles and lipophiles in aqueous solutions show that the amphiphiles with an active isomerization kinetics can perform a spontaneous break of symmetry during the segregation and self-assembly to homochiral matter. Based on this observation it is argued that biomolecules with a sufficiently strong chiral discrimination could be the origin of homochirality in biological systems.
Keywords: Origin of chirality; Origin of Life; Prebiotic self-assambly Origin of chirality; Origin of Life; Prebiotic self-assambly
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Toxvaerd, S. Origin of Homochirality in Biosystems. Int. J. Mol. Sci. 2009, 10, 1290-1299.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top