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Int. J. Mol. Sci. 2009, 10(3), 1064-1080; doi:10.3390/ijms10031064
Review

Importance of Translational Entropy of Water in Biological Self-Assembly Processes like Protein Folding

Received: 26 January 2009; in revised form: 6 March 2009 / Accepted: 10 March 2009 / Published: 11 March 2009
(This article belongs to the Special Issue Protein Folding)
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Abstract: We briefly review our studies on the folding/unfolding mechanisms of proteins. In biological self-assembly processes such as protein folding, the number of accessible translational configurations of water in the system increases greatly, leading to a large gain in the water entropy. The usual view looking at only the water in the close vicinity of the protein surface is capable of elucidating neither the large entropic gain upon apoplastocyanin folding, which has recently been found in a novel experimental study, nor the pressure and cold denaturation. With the emphasis on the translational entropy of water, we are presently constructing a reliable method for predicting the native structure of a protein from its amino-acid sequence.
Keywords: Protein folding; self-assembly; water; translational entropy; pressure denaturation; cold denaturation; native structure Protein folding; self-assembly; water; translational entropy; pressure denaturation; cold denaturation; native structure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kinoshita, M. Importance of Translational Entropy of Water in Biological Self-Assembly Processes like Protein Folding. Int. J. Mol. Sci. 2009, 10, 1064-1080.

AMA Style

Kinoshita M. Importance of Translational Entropy of Water in Biological Self-Assembly Processes like Protein Folding. International Journal of Molecular Sciences. 2009; 10(3):1064-1080.

Chicago/Turabian Style

Kinoshita, Masahiro. 2009. "Importance of Translational Entropy of Water in Biological Self-Assembly Processes like Protein Folding." Int. J. Mol. Sci. 10, no. 3: 1064-1080.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert