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Molecules 2018, 23(2), 299; doi:10.3390/molecules23020299

Terretonin N: A New Meroterpenoid from Nocardiopsis sp.

1
Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
2
Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt
3
Department of Microbial Chemistry, Division of Genetic Engineering and Biotechnology Research, National Research Centre, El-Buhouth St. 33, Dokki-Cairo 12622, Egypt
4
Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
5
Department of Chemistry of Natural Compounds, Pharmaceutical and Drug Industries Research Division, National Research Centre, El-Buhouth St. 33, Dokki-Cairo 12622, Egypt
*
Authors to whom correspondence should be addressed.
Received: 21 December 2017 / Revised: 26 January 2018 / Accepted: 28 January 2018 / Published: 31 January 2018
(This article belongs to the Section Natural Products)
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Abstract

Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of 1 were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of Nocardiopsis sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound 1 were studied using different microorganisms and a cervix carcinoma cell line, respectively. View Full-Text
Keywords: Nocardiopsis sp. LGO5; terretonin N; 6-hydroxymeroterpenoid; antimicrobial activity; cytotoxicity Nocardiopsis sp. LGO5; terretonin N; 6-hydroxymeroterpenoid; antimicrobial activity; cytotoxicity
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MDPI and ACS Style

Hamed, A.; Abdel-Razek, A.S.; Frese, M.; Stammler, H.G.; El-Haddad, A.F.; Ibrahim, T.M.A.; Sewald, N.; Shaaban, M. Terretonin N: A New Meroterpenoid from Nocardiopsis sp.. Molecules 2018, 23, 299.

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