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Molecules 2016, 21(3), 243; doi:10.3390/molecules21030243

New Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae)

Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation—State Research Institute, ul. Czartoryskich 8, 24-100 Puławy, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 January 2016 / Revised: 11 February 2016 / Accepted: 19 February 2016 / Published: 24 February 2016
(This article belongs to the Section Metabolites)
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Abstract

An aqueous extract from the roots of Kalanchoe daigremontiana turned out to be a rich source of bufadienolides. The existing literature data relate mainly to the aerial parts of Kalanchoe but there is no information about the metabolic profile of the roots, which are also used in traditional medicine. Our investigation concerning the roots of K. daigremontiana led to the isolation and characterization of eight new bufadienolides, namely 1β,3β,5β,14β,19-pentahydroxybufa-20,22-dienolide (1), 19-(acetyloxy)-1β,3β,5β,14β-tetrahydroxybufa-20,22-dienolide (2), 3β-O-α-l-rhamno-pyranosyl-5β,11α,14β,19-tetrahydroxybufa-20,22-dienolide (3), 19-(acetyloxy)-3β,5β,11α,14β-tetrahydroxybufa-20,22-dienolide (4), 3β,5β,11α,14β,19-pentahydroxy-12-oxo-bufa-20,22-dienolide (5), 19-(acetyloxy)-3β,5β,11α,14β-tetrahydroxy-12-oxo-bufa-20,22-dienolide (6), 19-(acetyloxy)-1β,3β,5β,11α,14β-pentahydroxy-12-oxo-bufa-20,22-dienolide (7) and 1β-(acetyloxy)-3β,5β,11α,14β,19-pentahydroxy-12-oxo-bufa-20,22-dienolide (8), together with seven known compounds: 11α,19-dihydroxytelocinobufagin (9), bersaldegenin-1-acetate (10), daigredorigenin-3-acetate (11), bersaldegenin-1,3,5-orthoacetate (12), bryotoxin B (13), bryophyllin B (14) and bersaldegenin (15). The structures were established applying extensive 1D- and 2D-NMR and MS spectroscopic analyses. View Full-Text
Keywords: Kalanchoe daigremontiana; Crassulaceae; bufadienolides; NMR Kalanchoe daigremontiana; Crassulaceae; bufadienolides; NMR
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MDPI and ACS Style

Moniuszko-Szajwaj, B.; Pecio, Ł.; Kowalczyk, M.; Stochmal, A. New Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae). Molecules 2016, 21, 243.

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