New Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae)
AbstractAn aqueous extract from the roots of Kalanchoe daigremontiana turned out to be a rich source of bufadienolides. The existing literature data relate mainly to the aerial parts of Kalanchoe but there is no information about the metabolic profile of the roots, which are also used in traditional medicine. Our investigation concerning the roots of K. daigremontiana led to the isolation and characterization of eight new bufadienolides, namely 1β,3β,5β,14β,19-pentahydroxybufa-20,22-dienolide (1), 19-(acetyloxy)-1β,3β,5β,14β-tetrahydroxybufa-20,22-dienolide (2), 3β-O-α-l-rhamno-pyranosyl-5β,11α,14β,19-tetrahydroxybufa-20,22-dienolide (3), 19-(acetyloxy)-3β,5β,11α,14β-tetrahydroxybufa-20,22-dienolide (4), 3β,5β,11α,14β,19-pentahydroxy-12-oxo-bufa-20,22-dienolide (5), 19-(acetyloxy)-3β,5β,11α,14β-tetrahydroxy-12-oxo-bufa-20,22-dienolide (6), 19-(acetyloxy)-1β,3β,5β,11α,14β-pentahydroxy-12-oxo-bufa-20,22-dienolide (7) and 1β-(acetyloxy)-3β,5β,11α,14β,19-pentahydroxy-12-oxo-bufa-20,22-dienolide (8), together with seven known compounds: 11α,19-dihydroxytelocinobufagin (9), bersaldegenin-1-acetate (10), daigredorigenin-3-acetate (11), bersaldegenin-1,3,5-orthoacetate (12), bryotoxin B (13), bryophyllin B (14) and bersaldegenin (15). The structures were established applying extensive 1D- and 2D-NMR and MS spectroscopic analyses. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 2297 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Moniuszko-Szajwaj, B.; Pecio, Ł.; Kowalczyk, M.; Stochmal, A. New Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae). Molecules 2016, 21, 243.
Moniuszko-Szajwaj B, Pecio Ł, Kowalczyk M, Stochmal A. New Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae). Molecules. 2016; 21(3):243.Chicago/Turabian Style
Moniuszko-Szajwaj, Barbara; Pecio, Łukasz; Kowalczyk, Mariusz; Stochmal, Anna. 2016. "New Bufadienolides Isolated from the Roots of Kalanchoe daigremontiana (Crassulaceae)." Molecules 21, no. 3: 243.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.