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Molecules 2010, 15(8), 5124-5138; doi:10.3390/molecules15085124

Antiplatelet Aggregation and Platelet Activating Factor (PAF) Receptor Antagonistic Activities of the Essential Oils of Five Goniothalamus Species

1
Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
2
Faculty of Resources Science and Technology, Universiti Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
*
Author to whom correspondence should be addressed.
Received: 21 June 2010 / Revised: 22 July 2010 / Accepted: 23 July 2010 / Published: 29 July 2010
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Abstract

Nine essential oils, hydrodistilled from different parts of five Goniothalamus species (G. velutinus Airy-Shaw, G. woodii Merr., G. clemensii Ban, G. tapis Miq. and G. tapisoides Mat Salleh) were evaluated for their ability to inhibit platelet aggregation in human whole blood using an electrical impedance method and their inhibitory effects on platelet activating factor (PAF) receptor binding with rabbit platelets using 3H-PAF as a ligand. The chemical composition of the oils was analyzed by gas chromatography (GC) and gas chromatography–mass spectrometry (GC–MS). The bark oil of G. velutinus was the most effective sample as it inhibited both arachidonic acid (AA) and ADP-induced platelet aggregation with IC50 values of 93.6 and 87.7 µg/mL, respectively. Among the studied oils, the bark oils of G. clemensii, G. woodii, G. velutinus and the root oil of G. tapis showed significant inhibitory effects on PAF receptor binding, with IC50 values ranging from 3.5 to 10.5 µg/mL. The strong PAF antagonistic activity of the active oils is related to their high contents of sesquiterpenes and sesquiterpenoids, and the individual components in the oils could possibly produce a synergistic effect in the overall antiplatelet activity of the oils.
Keywords: Goniothalamus species; essential oils; GC-MS; antiplatelet aggregation; platelet activating factor (PAF) antagonists Goniothalamus species; essential oils; GC-MS; antiplatelet aggregation; platelet activating factor (PAF) antagonists
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Moharam, B.A.; Jantan, I.; Ahmad, F.; Jalil, J. Antiplatelet Aggregation and Platelet Activating Factor (PAF) Receptor Antagonistic Activities of the Essential Oils of Five Goniothalamus Species. Molecules 2010, 15, 5124-5138.

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