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Molecules 2008, 13(4), 943-947; doi:10.3390/molecules13040943
Communication

Efficient and Eco-Friendly Preparation of 4-Methyl-5-formyl-thiazole

, *  and
The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China
* Author to whom correspondence should be addressed.
Received: 6 April 2008 / Revised: 17 April 2008 / Accepted: 17 April 2008 / Published: 21 April 2008
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Abstract

4-Methyl-5-formylthiazole, an intermediate for synthesizing cefditoren pivoxil,was prepared in good yield by Pd/BaSO4 catalyzed hydrogenation of 4-methylthiazole-5-carboxylic acid chloride. Detailed reaction conditions have been studied.
Keywords: 4-Methyl-5-formylthiazole; Pd/BaSO4 catalyzed hydrogenation. 4-Methyl-5-formylthiazole; Pd/BaSO4 catalyzed hydrogenation.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Bai, N.; Sha, Y.; Meng, G. Efficient and Eco-Friendly Preparation of 4-Methyl-5-formyl-thiazole. Molecules 2008, 13, 943-947.

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