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Efficient and Eco-Friendly Preparation of 4-Methyl-5-formyl-thiazole
The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China
* Author to whom correspondence should be addressed.
Received: 6 April 2008; in revised form: 17 April 2008 / Accepted: 17 April 2008 / Published: 21 April 2008
Abstract: 4-Methyl-5-formylthiazole, an intermediate for synthesizing cefditoren pivoxil,was prepared in good yield by Pd/BaSO4 catalyzed hydrogenation of 4-methylthiazole-5-carboxylic acid chloride. Detailed reaction conditions have been studied.
Keywords: 4-Methyl-5-formylthiazole; Pd/BaSO4 catalyzed hydrogenation.
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Cite This Article
MDPI and ACS Style
Bai, N.; Sha, Y.; Meng, G. Efficient and Eco-Friendly Preparation of 4-Methyl-5-formyl-thiazole. Molecules 2008, 13, 943-947.
Bai N, Sha Y, Meng G. Efficient and Eco-Friendly Preparation of 4-Methyl-5-formyl-thiazole. Molecules. 2008; 13(4):943-947.
Bai, Nan; Sha, Yaowu; Meng, Ge. 2008. "Efficient and Eco-Friendly Preparation of 4-Methyl-5-formyl-thiazole." Molecules 13, no. 4: 943-947.