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Molecules 2008, 13(4), 943-947; doi:10.3390/molecules13040943

Efficient and Eco-Friendly Preparation of 4-Methyl-5-formyl-thiazole

, *  and
The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China
* Author to whom correspondence should be addressed.
Received: 6 April 2008 / Revised: 17 April 2008 / Accepted: 17 April 2008 / Published: 21 April 2008
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4-Methyl-5-formylthiazole, an intermediate for synthesizing cefditoren pivoxil,was prepared in good yield by Pd/BaSO4 catalyzed hydrogenation of 4-methylthiazole-5-carboxylic acid chloride. Detailed reaction conditions have been studied.
Keywords: 4-Methyl-5-formylthiazole; Pd/BaSO4 catalyzed hydrogenation. 4-Methyl-5-formylthiazole; Pd/BaSO4 catalyzed hydrogenation.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bai, N.; Sha, Y.; Meng, G. Efficient and Eco-Friendly Preparation of 4-Methyl-5-formyl-thiazole. Molecules 2008, 13, 943-947.

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