Journal of Personalized Medicine

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Special Issue Editor

Special Issue Information

Dear Colleagues,

Psoriatic arthritis represents a condition whose clinical expressiveness can be extremely heterogeneous. The wide clinical variability often results in diagnostic pitfalls, hence the need for a personalized approach on multiple fronts: from the use of sophisticated imaging techniques, to clinimetry according to prevalent manifestations, to treatment. The high prevalence of coexisting fibromyalgia can complicate the evaluation of these patients.

With these issues as our focus, I am delighted to invite you to contribute to this Special Issue, aimed at emphasizing the need for personalization in the setting of psoriatic arthritis.

Areas covered by this Special Issue (both original contributions and literature reviews are welcome) include, but are not limited to:

The use of imaging techniques in the diagnosis of psoriatic arthritis and its major manifestations (synovitis, enthesitis, dactylitis, axial involvement);
The clinimetric approach with reference to inflammatory manifestations and disease impact on quality of life;
The burden of comorbidities, including fibromyalgia among them;
Therapeutic personalization.

I look forward to your contribution.

Best regards,

Dr. Marco Di Carlo
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

psoriatic arthritis
imaging
synovitis
dactylitis
enthesitis
comorbidities
clinimetry
biologic DMARDs
targeted synthetic DMARDs

Published Papers (2 papers)

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Research

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15 pages, 1417 KiB

Open AccessArticle

The Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts): Measurement Properties of a New Multidimensional Composite Tool for the Quick Assessment of the Overall Health Status in Psoriatic Arthritis

by Fausto Salaffi, Marina Carotti, Sonia Farah and Marco Di Carlo

J. Pers. Med. 2023, 13(7), 1153; https://doi.org/10.3390/jpm13071153 - 18 Jul 2023

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Abstract

Background: Psoriatic arthritis (PsA) is a heterogeneous condition that is difficult to assess. The goal of this research was to evaluate the clinimetric properties of the Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts), a new patient-reported outcome (PRO) to measure the overall health status in PsA patients. Methods: The PsA-5Ts were compared to composite measures of disease activity (DAPSA, PASDAS, CPDAI) and PROs (PsAID-12 and SF-36). The convergent validity was assessed through the Spearman’s correlation coefficient and the discriminant validity through the receiver operating characteristic (ROC) curve analysis, applying the Minimal Disease Activity (MDA) as an external criterion. Results: The cross-sectional assessment included 155 patients. Significant high correlations were observed when comparing PsA-5Ts to composite indices of disease activity and PROs (all at significance levels of p < 0.0001). The PsA-5Ts subscales were highly significantly different in terms of MDA status (all at p < 0.0001). The PsA-5Ts had good discriminant validity like that of the DAPSA, CPDAI, PASDAS, and PsAID-12, and better than that of the SF-36, with an area under the ROC curve of 0.944 (65% CI 0.895–0.974). Conclusions: The PsA-5Ts are an easy-to-use PRO that can be integrated with disease activity indices in the assessment of PsA in daily clinical practice. Full article

(This article belongs to the Special Issue Psoriatic Arthritis and the Need to Personalize Diagnosis, Clinimetry, and Treatment)

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Review

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14 pages, 2258 KiB

Open AccessReview

Ultrasonographic Insights into Peripheral Psoriatic Arthritis: Updates in Diagnosis and Monitoring

by Karina Rossi Bonfiglioli, Fernanda Oliveira de Andrade Lopes, Letícia Queiroga de Figueiredo, Luis Fernando Fernandes Ferrari and Lissiane Guedes

J. Pers. Med. 2024, 14(6), 550; https://doi.org/10.3390/jpm14060550 - 22 May 2024

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Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis, characterized by heterogeneous clinical manifestations and variable disease progression. Ultrasonography has emerged as a valuable tool in the diagnosis and monitoring of PsA, providing real-time visualization of joint and soft tissue abnormalities. This review highlights recent advancements in ultrasonographic techniques for the assessment of PsA, including the identification of typical features, the role of power Doppler imaging in detecting active inflammation, and the potential of ultrasound for guiding treatment decisions. Additionally, we discuss the utility of ultrasound in assessing treatment response and monitoring disease progression in patients with PsA, with a focus on novel imaging modalities. By elucidating the evolving role of ultrasonography in PsA management, this article aims to enhance clinicians’ understanding of its utility in facilitating early diagnosis, optimizing treatment strategies, and improving patient outcomes. Full article

(This article belongs to the Special Issue Psoriatic Arthritis and the Need to Personalize Diagnosis, Clinimetry, and Treatment)

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