Aldo-Keto Reductases: Functions, Molecular Mechanisms and Regulation
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Enzymology".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 313
Special Issue Editors
Interests: protein biochemistry; protein purification; enzymes; enzyme kinetics; enzyme inhibition; oxidative stress; aldose reductase
Special Issues, Collections and Topics in MDPI journals
Interests: oxidative stress; protein thiolation; carbonyl metabolism; enzyme inhibition; diabetic complications; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The aldo-keto reductase (AKR) superfamily (https://akrsuperfamily.org/) comprises 15 different families (AKR1 to AKR15) of enzymes that catalyse the NAD(P)H-dependent reduction of the aldehydic and carbonyl groups of a variety of substrates, including glucose, lipid peroxidation products, steroids, prostaglandins. AKR genes are expressed in most tissues of all plants and animals and also in many microorganisms. AKRs share a common (β/α)8 barrel structure and present a binding site for the cofactor which changes upon the binding of the cofactor, inducing a significant structural rearrangement that precedes the binding of the substrate. Due to their broad substrate specificity, AKRs are involved in several metabolic pathways and have been shown to be implicated in a number of human diseases, such as diabetes and inflammation. Therefore, AKRs have been proposed as possible therapeutic targets for the treatment of such pathological states.
This Special Issue will focus on the molecular mechanisms, functions and regulation of AKRs and will include reviews and research articles on these topics with the aim of presenting the state of the art on knowledge of these multifunctional enzymes.
Dr. Mario Cappiello
Prof. Dr. Antonella Del Corso
Guest Editors
Manuscript Submission Information
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Keywords
- aldo-keto reductases
- NAD(P)(H)-dependent oxidoreductases
- diabetes
- inflammation
- detoxification
