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Biomedical Imaging and Analysis of the Eye: Second Edition

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A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2905

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Special Issue Editors

Dr. Xuejun Qian

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Guest Editor

School of Biomedical Engineering, Shanghai Tech University, Shanghai, China
Interests: biomedical imaging; multi-modal imaging; functional imaging; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Qifa Zhou

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Guest Editor

Department of Biomedical Engineering and Ophthalmology, University of Southern California, Los Angeles, CA 90007, USA
Interests: MEMS; biomedical imaging; photoacoustic imaging; ultrasound; elastography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The eye is an important aspect of human health since people rely on their eyes to see and make sense of the world around them. Investigating the condition of the eye is not only important to identify eye diseases but also to predict the risk of non-ocular diseases such as diabetes, anemia, cardiovascular risk, chronic kidney disease, and other systemic parameters.

The aim of this Special Issue is to provide a forum to share insights into medical imaging modalities and machine/deep learning tools to advance the development of algorithms, systems, and clinical applicability for imaging and analyzing the eye. We welcome both original research and review articles. Potential topics include, but are not limited to, the following:

Advanced imaging technique and system for the eye;
Machine or deep learning-based image analysis using eye imaging;
Imaging-guided eye surgery and treatment;
Image processing in ocular imaging;
Mathematical or statistical modeling of the eye;
Multi-dimensional and multi-modality fusion ocular imaging.

You may like to read the papers in our precious issue:

Volume 1 (10 papers): https://www.mdpi.com/journal/bioengineering/special_issues/S2G5Q9113W

Dr. Xuejun Qian
Prof. Dr. Qifa Zhou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

ultrasound imaging
optical coherence tomography
functional imaging
machine/deep learning
ocular tissue

Related Special Issue

Biomedical Imaging and Analysis of the Eye in Bioengineering (10 articles)

Published Papers (3 papers)

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Research

11 pages, 1271 KiB

Open AccessArticle

Real-World Weekly Efficacy Analysis of Faricimab in Patients with Age-Related Macular Degeneration

by Daniel R. Muth, Katrin F. Fasler, Anders Kvanta, Magdalena Rejdak, Frank Blaser and Sandrine A. Zweifel

Bioengineering 2024, 11(5), 478; https://doi.org/10.3390/bioengineering11050478 - 10 May 2024

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Abstract

Objectives: This study entailed a weekly analysis of real-world data (RWD) on the safety and efficacy of intravitreal (IVT) faricimab in neovascular age-related macular degeneration (nAMD). Methods: A retrospective, single-centre clinical trial was conducted at the Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland, approved by the Cantonal Ethics Committee of Zurich, Switzerland. Patients with nAMD were included. Data from patient charts and imaging were analysed. The safety and efficacy of the first faricimab injection were evaluated weekly until 4 weeks after injection. Results: Sixty-three eyes with a complete 4-week follow-up were enrolled. Six eyes were treatment-naïve; fifty-seven eyes were switched to faricimab from another treatment. Neither group showed signs of retinal vasculitis during the 4 weeks after injection. Central subfield thickness (CST) and volume (CSV) showed a statistically significant decrease compared to the baseline in the switched group (CST: p = 0.00383; CSV: p = 0.00702) after 4 weeks. The corrected visual acuity returned to the baseline level in both groups. The macular neovascularization area decreased in both groups, but this was not statistically significant. A complete resolution of sub- and intraretinal fluid after 4 weeks was found in 40% (switched) and 75% (naïve) of the treated patients. Conclusions: The weekly follow-ups reflect the structure–function relationship beginning with a fast functional improvement within two weeks after injection followed by a return to near-baseline levels after week 3. The first faricimab injection in our cohort showed a high safety profile and a statistically significant reduction in macular oedema in switched nAMD patients. Full article

(This article belongs to the Special Issue Biomedical Imaging and Analysis of the Eye: Second Edition)

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16 pages, 4769 KiB

Open AccessArticle

OCT Intensity of the Region between Outer Retina Band 2 and Band 3 as a Biomarker for Retinal Degeneration and Therapy

by Yong Zeng, Shasha Gao, Yichao Li, Dario Marangoni, Tharindu De Silva, Wai T. Wong, Emily Y. Chew, Xun Sun, Tiansen Li, Paul A. Sieving and Haohua Qian

Bioengineering 2024, 11(5), 449; https://doi.org/10.3390/bioengineering11050449 - 1 May 2024

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Abstract

Optical coherence tomography (OCT) is widely used to probe retinal structure and function. This study investigated the outer retina band (ORB) pattern and reflective intensity for the region between bands 2 and 3 (Dip) in three mouse models of inherited retinal degeneration (Rs1KO, TTLL5KO, RPE65KO) and in human AMD patients from the A2A database. OCT images were manually graded, and reflectivity signals were used to calculate the Dip ratio. Qualitative analyses demonstrated the progressive merging band 2 and band 3 in all three mouse models, leading to a reduction in the Dip ratio compared to wildtype (WT) controls. Gene replacement therapy in Rs1KO mice reverted the ORB pattern to one resembling WT and increased the Dip ratio. The degree of anatomical rescue in these mice was highly correlated with level of transgenic RS1 expression and with the restoration of ERG b-wave amplitudes. While the inner retinal cavity was significantly enlarged in dark-adapted Rs1KO mice, the Dip ratio was not altered. A reduction of the Dip ratio was also detected in AMD patients compared with healthy controls and was also positively correlated with AMD severity on the AMD score. We propose that the ORB and Dip ratio can be used as non-invasive early biomarkers for retina health, which can be used to probe therapeutic gene expression and to evaluate the effectiveness of therapy. Full article

(This article belongs to the Special Issue Biomedical Imaging and Analysis of the Eye: Second Edition)

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11 pages, 2285 KiB

Open AccessArticle

Ultrasound Flow Imaging Study on Rat Brain with Ultrasound and Light Stimulations

by Junhang Zhang, Chen Gong, Zihan Yang, Fan Wei, Xin Sun, Jie Ji, Yushun Zeng, Chi-feng Chang, Xunan Liu, Deepthi S. Rajendran Nair, Biju B. Thomas and Qifa Zhou

Bioengineering 2024, 11(2), 174; https://doi.org/10.3390/bioengineering11020174 - 10 Feb 2024

Viewed by 1185

Abstract

Functional ultrasound (fUS) flow imaging provides a non-invasive method for the in vivo study of cerebral blood flow and neural activity. This study used functional flow imaging to investigate rat brain’s response to ultrasound and colored-light stimuli. Male Long-Evan rats were exposed to direct full-field strobe flashes light and ultrasound stimulation to their retinas, while brain activity was measured using high-frequency ultrasound imaging. Our study found that light stimuli, particularly blue light, elicited strong responses in the visual cortex and lateral geniculate nucleus (LGN), as evidenced by changes in cerebral blood volume (CBV). In contrast, ultrasound stimulation elicited responses undetectable with fUS flow imaging, although these were observable when directly measuring the brain’s electrical signals. These findings suggest that fUS flow imaging can effectively differentiate neural responses to visual stimuli, with potential applications in understanding visual processing and developing new diagnostic tools. Full article

(This article belongs to the Special Issue Biomedical Imaging and Analysis of the Eye: Second Edition)

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