Biology 2014, 3(2), 243-254; doi:10.3390/biology3020243
Review

RNA Splicing Factors and RNA-Directed DNA Methylation

1,* email and 2,3,* email
Received: 17 February 2014; in revised form: 18 March 2014 / Accepted: 20 March 2014 / Published: 26 March 2014
(This article belongs to the Special Issue DNA Methylation)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: RNA-directed histone and/or DNA modification is a conserved mechanism for the establishment of epigenetic marks from yeasts and plants to mammals. The heterochromation formation in yeast is mediated by RNAi-directed silencing mechanism, while the establishment of DNA methylation in plants is through the RNA-directed DNA methylation (RdDM) pathway. Recently, splicing factors are reported to be involved in both RNAi-directed heterochromatin formation in yeast and the RdDM pathway in plants. In yeast, splicing factors may provide a platform for facilitating the siRNA generation through an interaction with RDRC and thereby affect the heterochromatin formation, whereas in plants, various splicing factors seem to act at different steps in the RdDM pathway.
Keywords: splicing; DNA methylation; heterochromatin formation; siRNA; epigenetic regulation
PDF Full-text Download PDF Full-Text [219 KB, Updated Version, uploaded 28 March 2014 15:09 CET]
The original version is still available [360 KB, uploaded 26 March 2014 09:31 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Huang, C.-F.; Zhu, J.-K. RNA Splicing Factors and RNA-Directed DNA Methylation. Biology 2014, 3, 243-254.

AMA Style

Huang C-F, Zhu J-K. RNA Splicing Factors and RNA-Directed DNA Methylation. Biology. 2014; 3(2):243-254.

Chicago/Turabian Style

Huang, Chao-Feng; Zhu, Jian-Kang. 2014. "RNA Splicing Factors and RNA-Directed DNA Methylation." Biology 3, no. 2: 243-254.

Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert