Next Article in Journal
Nanotherapy and Reactive Oxygen Species (ROS) in Cancer: A Novel Perspective
Previous Article in Journal
Appropriate Handling, Processing and Analysis of Blood Samples Is Essential to Avoid Oxidation of Vitamin C to Dehydroascorbic Acid
Previous Article in Special Issue
Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Antioxidants 2018, 7(2), 30; https://doi.org/10.3390/antiox7020030

Morphological Pathways of Mitochondrial Division

1
Center for Mitochondrial Disease, Cleveland, OH 44106, USA
2
Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
3
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
4
Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
*
Author to whom correspondence should be addressed.
Received: 11 December 2017 / Revised: 12 February 2018 / Accepted: 14 February 2018 / Published: 15 February 2018
(This article belongs to the Special Issue Mitochondrial Shape Change in Physio-Pathology)
View Full-Text   |   Download PDF [862 KB, uploaded 22 February 2018]   |  

Abstract

Mitochondrial fission is essential for distributing cellular energy throughout cells and for isolating damaged regions of the organelle that are targeted for degradation. Excessive fission is associated with the progression of cell death as well. Therefore, this multistep process is tightly regulated and several physiologic cues directly impact mitochondrial division. The double membrane structure of mitochondria complicates this process, and protein factors that drive membrane scission need to coordinate the separation of both the outer and inner mitochondrial membranes. In this review, we discuss studies that characterize distinct morphological changes associated with mitochondrial division. Specifically, coordinated partitioning and pinching of mitochondria have been identified as alternative mechanisms associated with fission. Additionally, we highlight the major protein constituents that drive mitochondrial fission and the role of connections with the endoplasmic reticulum in establishing sites of membrane division. Collectively, we review decades of research that worked to define the molecular framework of mitochondrial fission. Ongoing studies will continue to sort through the complex network of interactions that drive this critical event. View Full-Text
Keywords: mitochondria; morphology; mitochondrial fission and fusion; inter-organelle contacts; mitochondrial dynamics mitochondria; morphology; mitochondrial fission and fusion; inter-organelle contacts; mitochondrial dynamics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Tandler, B.; Hoppel, C.L.; Mears, J.A. Morphological Pathways of Mitochondrial Division. Antioxidants 2018, 7, 30.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top