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Antioxidants 2016, 5(4), 44; doi:10.3390/antiox5040044

Blueberries’ Impact on Insulin Resistance and Glucose Intolerance

Department of Human Ecology, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA
Academic Editor: Dorothy Klimis-Zacas
Received: 17 October 2016 / Revised: 17 November 2016 / Accepted: 18 November 2016 / Published: 29 November 2016
(This article belongs to the Special Issue Berry Antioxidants in Health and Disease)
View Full-Text   |   Download PDF [656 KB, uploaded 29 November 2016]   |  

Abstract

Blueberries are a rich source of polyphenols, which include anthocyanin bioactive compounds. Epidemiological evidence indicates that incorporating blueberries into the diet may lower the risk of developing type 2 diabetes (T2DM). These findings are supported by pre-clinical and clinical studies that have shown improvements in insulin resistance (i.e., increased insulin sensitivity) after obese and insulin-resistant rodents or humans consumed blueberries. Insulin resistance was assessed by homeostatic model assessment-estimated insulin resistance (HOMA-IR), insulin tolerance tests, and hyperinsulinemic-euglycemic clamps. Additionally, the improvements in glucose tolerance after blueberry consumption were assessed by glucose tolerance tests. However, firm conclusions regarding the anti-diabetic effect of blueberries cannot be drawn due to the small number of existing clinical studies. Although the current evidence is promising, more long-term, randomized, and placebo-controlled trials are needed to establish the role of blueberries in preventing or delaying T2DM. View Full-Text
Keywords: blueberries; bilberries; strawberries; cranberries; berries; anthocyanins; diabetes; insulin; glucose; diabetes blueberries; bilberries; strawberries; cranberries; berries; anthocyanins; diabetes; insulin; glucose; diabetes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Stull, A.J. Blueberries’ Impact on Insulin Resistance and Glucose Intolerance. Antioxidants 2016, 5, 44.

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