Next Article in Journal
Previous Article in Journal
Antioxidants 2014, 3(2), 323-338; doi:10.3390/antiox3020323
Article

Hepatoprotective and Antioxidant Potential of Organic and Conventional Grape Juices in Rats Fed a High-Fat Diet

1
, 1
, 1
, 1
, 2
, 3
, 2
, 4,5
, 1
 and 1,*
Received: 11 January 2014; in revised form: 2 April 2014 / Accepted: 2 April 2014 / Published: 30 April 2014
View Full-Text   |   Download PDF [846 KB, uploaded 30 April 2014]   |   Browse Figures
Abstract: The objective of this study was to investigate the antioxidant and hepatoprotective effect of the chronic use of conventional (CGJ) or organic (OGJ) grape juice from the Bordeaux variety grape on oxidative stress and cytoarchitecture in the liver of rats supplemented with a high-fat diet (HFD) for three months. The results demonstrated that HFD induced an increase in thiobarbituric acid-reactive substances (TBARS), catalase (CAT) activity and 2′,7′-dihydrodichlorofluorescein (DCFH) oxidation and a decrease in sulfhydryl content and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. HFD also induced hepatocellular degeneration and steatosis. These alterations were prevented by CGJ and OGJ, where OGJ was more effective. Therefore, it was concluded that HFD induced oxidative stress and liver damage and that the chronic use of grape juice was able to prevent these alterations.
Keywords: liver; antioxidants; grapes; high-fat diet; free radicals liver; antioxidants; grapes; high-fat diet; free radicals
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Buchner, I.; Medeiros, N.; Lacerda, D.S.; Normann, C.A.B.M.; Gemelli, T.; Rigon, P.; Wannmacher, C.M.D.; Henriques, J.A.P.; Dani, C.; Funchal, C. Hepatoprotective and Antioxidant Potential of Organic and Conventional Grape Juices in Rats Fed a High-Fat Diet. Antioxidants 2014, 3, 323-338.

AMA Style

Buchner I, Medeiros N, Lacerda DS, Normann CABM, Gemelli T, Rigon P, Wannmacher CMD, Henriques JAP, Dani C, Funchal C. Hepatoprotective and Antioxidant Potential of Organic and Conventional Grape Juices in Rats Fed a High-Fat Diet. Antioxidants. 2014; 3(2):323-338.

Chicago/Turabian Style

Buchner, Iselde; Medeiros, Niara; Lacerda, Denise S.; Normann, Carlos A.B.M.; Gemelli, Tanise; Rigon, Paula; Wannmacher, Clovis M.D.; Henriques, João A.P.; Dani, Caroline; Funchal, Cláudia. 2014. "Hepatoprotective and Antioxidant Potential of Organic and Conventional Grape Juices in Rats Fed a High-Fat Diet." Antioxidants 3, no. 2: 323-338.

Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert