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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neural Crest Development in Health and Disease (Volume 2)
edited by
submission deadline 5 Jun 2024 | 4 articles | Viewed by 8591 | Submission Open
Keywords: animal models; cellular models; cell fate determination; cell metabolism; cell migration; cell signaling; disease modeling; evolution; gene– environment interactions; gene regulatory networks; neural-crest-related congenital malformations; neural-crest-related cancers; molecular genetics; molecular therapies; pathogenic mechanisms; stem-cell-based therapies
(This special issue belongs to the Section Molecular Neurobiology)
Colorectal Cancer: A Molecular Genetics Perspective
edited by
submission deadline 10 Jun 2024 | 10 articles | Viewed by 15054 | Submission Open
Keywords: colorectal cancer; chromosomal and Microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Mitochondrial Dysfunction in Neurodegenerative Diseases submission deadline 10 Jun 2024 | 5 articles | Viewed by 12009 | Submission Open
Keywords: neurodegeneration; mitochondria; biomarker; therapeutics; clinical development
(This special issue belongs to the Section Molecular Neurobiology)
Recent Advances in Human Genetics submission deadline 10 Jun 2024 | 6 articles | Viewed by 11166 | Submission Open
Keywords: human genomics; mutation; sequencing; variants; human microevolution; epigenomic; human diversity
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research of Viral Infections submission deadline 10 Jun 2024 | 6 articles | Viewed by 10446 | Submission Open
(This special issue belongs to the Section Molecular Microbiology)
State-of-the-Art Molecular Neurobiology in Poland
edited by
submission deadline 10 Jun 2024 | 4 articles | Viewed by 9568 | Submission Open
Keywords: neurobiology; neurochemistry; neuropathology; neurophysiology; neuropharmacology; neurogenetics; neurodegeneration; aging neuroscience; neurogenesis; neuroplasticity; signalling pathways; signalling networks; systems biology; stress-related processes
(This special issue belongs to the Section Molecular Neurobiology)
Nanotoxicology and Nanosafety 4.0
edited by
submission deadline 10 Jun 2024 | 4 articles | Viewed by 9031 | Submission Open
Keywords: molecular and cellular mechanisms of nanomaterial intoxication  ; regulatory toxicology  ; nanotoxicology  ; nanosafety  ; alternative testing methods  ; ecotoxicity of nanomaterials  ; adverse effects of nanomaterials in zebrafish  ; adverse effects of nanomaterials in Drosophila  ; adverse effects of nanomaterials in C. elegans  ; risk assessment of engineered nanomaterials  ; risk management of engineered nanomaterials  ; biological monitoring of engineered nanomaterials  ; environmental monitoring of engineered nanomaterials
(This special issue belongs to the Section Molecular Toxicology)
Non-coding RNA in Physiology and Pathophysiology submission deadline 10 Jun 2024 | 5 articles | Viewed by 8615 | Submission Open
Keywords: microRNA; long non-coding RNA; circular RNA; epigenetics; cardiovascular disease; metabolic disease; nervous system disorders; cancer; aging
(This special issue belongs to the Section Molecular Biology)
RNA Biomarkers in Neuropsychiatric Disorders
edited by
submission deadline 10 Jun 2024 | 3 articles | Viewed by 5889 | Submission Open
Keywords: RNA biomarkers; neuropsychiatric disorders; RNA-seq; miR-seq; mRNA; ncRNAs; miRNAs; drug response biomarkers; drug– gene combination test; pharmacogenomics
(This special issue belongs to the Section Molecular Neurobiology)
The Contribution of Proteomics and Post-mortem Laboratory Investigations in Forensic Pathology
edited by
submission deadline 10 Jun 2024 | 4 articles | Viewed by 5414 | Submission Open
Keywords: proteomics; proteins; forensic biology; post mortem interval; forensic biochemistry
(This special issue belongs to the Section Biochemistry)
Recent Advances in Coordination Chemistry of Metal Complexes Based on Schiff Base Ligands: Structure-Property Relationships and Applications, 2nd Edition
edited by
submission deadline 10 Jun 2024 | 6 articles | Viewed by 4993 | Submission Open
Keywords: Schiff base; coordination chemistry; functional materials; supramolecular chemistry; metal complexes; nanocomposites; structure– property relationship
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Recent Research on Cell and Molecular Biology submission deadline 10 Jun 2024 | 3 articles | Viewed by 4799 | Submission Open
Keywords: Gene expression; Cellular signaling; Computational biology; Molecular mechanisms; Signal transduction; Epigenetics; Proteomics; Transcriptomics; DNA repair; Stem cells; Apoptosis; Cancer biology; Synthetic biology; Drug discovery; Molecular imaging; Genome engineering; CRISPR/Cas9; Immunology; Neurobiology; Metabolism; RNA Biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Molecular Biology on Ovarian Cancer and Prostate Cancer
edited by and Mónica Lamas-Maceiras
submission deadline 10 Jun 2024 | 2 articles | Viewed by 4559 | Submission Open
Keywords: ovarian cancer; prostate cancer; ncRNAs; genetic screening; advanced imaging techniques; biomarkers; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Ischemic Retinal Diseases: Pathophysiology, Retinal Imaging and Therapeutics submission deadline 10 Jun 2024 | 3 articles | Viewed by 4399 | Submission Open
Keywords: retinal ischemia diseases; excitotoxicity; oxidative stress; neurodegeneration; neuroinflammation; vasculopathy; neuroprotection; antioxidants; age-related macular degeneration; diabetic retinopathy; glaucoma; retinopathy of prematurity; retinal imaging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Molecular Research for Glioblastoma
edited by
submission deadline 10 Jun 2024 | 2 articles | Viewed by 3975 | Submission Open
Keywords: glioblastoma multiforme (GBM); personalized medicine; targeted drug delivery; nanoparticles; tumor microenvironment; drug resistance; non-coding RNAs; diagnosis and treatment
(This special issue belongs to the Section Molecular Oncology)
Molecular Studies of Natural Compounds and Plant Extracts 2.0
edited by
submission deadline 10 Jun 2024 | 4 articles | Viewed by 3818 | Submission Open
Keywords: bioactive substances; plant extracts; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic
(This special issue belongs to the Section Biochemistry)
Current Research on Cancer Drug Resistance submission deadline 10 Jun 2024 | 2 articles | Viewed by 3657 | Submission Open
Keywords: chemotherapy; drug resistance; immunotherapy; immunotherapy resistance; signal transduction
(This special issue belongs to the Section Molecular Oncology)
Radiobiology and Radiotherapy in Tumour
edited by and Eva Bezak
submission deadline 10 Jun 2024 | 2 articles | Viewed by 3095 | Submission Open
Keywords: accelerated repopulation; radiotherapy; chemotherapy; cancer stem cells; tumor microenvironment; cancer therapy; tumor metabolism; molecular mechanisms
(This special issue belongs to the Section Molecular Oncology)
Structural and Functional Characterization of Protein-Based Polymer Materials
edited by and
submission deadline 10 Jun 2024 | 1 articles | Viewed by 2813 | Submission Open
Keywords: drug or nutrients delivery; food packaging; cell culture medium; cartilage tissue regeneration; 3D printing
(This special issue belongs to the Section Macromolecules)
Vitamin D and Vitamin D Binding Protein in Health and Disease 3.0
edited by
submission deadline 10 Jun 2024 | 2 articles | Viewed by 2337 | Submission Open
Keywords: vitamin D; vitamin D binding protein (gc-globulin); vitamin D receptor; vitamin D deficiency; immunomodulation; chronic inflammatory diseases; osteoporosis; vitamin D deficiency
(This special issue belongs to the Section Macromolecules)
Neurodegeneration and Countermeasures to Slow Down Its Onset submission deadline 10 Jun 2024 | 1 articles | Viewed by 1810 | Submission Open
Keywords: neurodegeneration; cognitive decline; aging; countermeasures; physical exercise; nutrition; prevention
(This special issue belongs to the Section Molecular Neurobiology)
Pharmacological Approaches and Models of Physical Activity in the Treatment of Inflammatory Diseases and Cancer
edited by
submission deadline 10 Jun 2024 | 2 articles | Viewed by 1706 | Submission Open
Keywords: physical exercise; drugs; cytokines; inflammation; oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Advances in Microsporidian Genomes
edited by Eric Peyretaillade, Frédéric Delbac and Ivan Wawrzyniak
submission deadline 10 Jun 2024 | 1 articles | Viewed by 1125 | Submission Open
Keywords: microsporidian genome sequencing and annotation; functional genomics; epigenetics; genome evolution; genome adaptation; genome and gene regulation; gene functions and products; genes implicated in host– pathogen interactions
(This special issue belongs to the Section Molecular Microbiology)
Cyclodextrin-Based Polymer Systems for Biomedical Applications submission deadline 10 Jun 2024 | 1 articles | Viewed by 1027 | Submission Open
Keywords: cyclodextrins; polymers; grafting; drug delivery; hydrophobic drugs; wound healing; tissue engineering; antimicrobial systems; supramolecular systems
(This special issue belongs to the Section Macromolecules)
The Role of Natural Products in Cancer Therapy and Prevention
edited by Valentina Pagliara
submission deadline 10 Jun 2024 | 1 articles | Viewed by 995 | Submission Open
Keywords: natural products; cell invasiveness; natural anti-metastatic agent; signaling pathways; cancer therapy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Unveiling the Dynamic World of Adaptive Unfolded Protein Responses in Metabolic Disease: A Scientist’s Perspective
edited by
submission deadline 10 Jun 2024 | 1 articles | Viewed by 700 | Submission Open
Keywords: adaptive unfolded protein responses; metabolic disease; protein folding challenges; cellular resilience; metabolic intricacies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structure, Energy, and Dynamics of Molecular Interactions 2.0
edited by and Uko Maran
submission deadline 10 Jun 2024 | Viewed by 547 | Submission Open
Keywords: binding; conformation; affinity; complex; energy; structure; isothermal titration calorimetry; crystallography; molecular mechanics; quantum chemistry; quantitative structure– activity relationship; reaction kinetics; inhibitor; substrate; target; ligand; receptor; surface; interface
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Viral Infection in Pregnancy
edited by
submission deadline 10 Jun 2024 | Viewed by 344 | Submission Open
Keywords: pregnancy; viral infection; fetal development; antiviral therapy; vaccine; diagnosis; virus– host interaction; pathophysiology; COVID-19; SARS-CoV-2; Zika virus; influenza; cytomegalovirus; rubella; HSV; HIV; HBV
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Neuroradiology
edited by Rosario Pascarella
submission deadline 10 Jun 2024 | Viewed by 193 | Submission Open
Keywords: cerebrovascular; small vessel disease; neurodegeneration; neuro-oncology; vessel wall imaging
(This special issue belongs to the Section Molecular Neurobiology)
Endothelial Cell Signaling
edited by Xavier Figueroa
submission deadline 12 Jun 2024 | 2 articles | Viewed by 2465 | Submission Open
Keywords: endothelial cell signaling; endothelial dysfunction; endothelium-dependent vasodilation; nitric oxide; myoendothelial communication; endothelial cell barrier; angiogenesis; conducted vasomotor responses  
(This special issue belongs to the Section Molecular Biology)
New Insights in Translational Bioinformatics
edited by
submission deadline 14 Jun 2024 | 7 articles | Viewed by 9954 | Submission Open
Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology
(This special issue belongs to the Section Molecular Informatics)
Molecular Advances in Enzyme Kinetics
edited by
submission deadline 14 Jun 2024 | 2 articles | Viewed by 3621 | Submission Open
Keywords: biocatalysis; enzymes; enzyme and inhibitors screening; enzyme computational modelling; kinetic data analysis; documentation of enzymatic data
(This special issue belongs to the Section Biochemistry)
From Basic Science to Treatment Strategies: Personalized Cancer Therapy
edited by Atif Hussein
submission deadline 15 Jun 2024 | 8 articles | Viewed by 15057 | Submission Open
Keywords: targeted therapy; personalized medicine; immunotherapy; circulating tumor DNA; prognosis; genomic profiling; liquid biopsies
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances and Perspectives of Lung Disease
edited by
submission deadline 15 Jun 2024 | 8 articles | Viewed by 13453 | Submission Open
Keywords: lung disease; inflammation; regeneration; infection; drug discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Transcriptome Complexity in Cancer and Leukemia: Alternative Splicing and Beyond
edited by
submission deadline 15 Jun 2024 | 5 articles | Viewed by 7098 | Submission Open
Keywords: messenger RNA (mRNA); long non-coding RNA (lncRNA); circular RNA (circRNA); transcriptional regulation; transcriptomics; solid tumors; hematological malignancies; biomarkers; therapeutic targets; therapy resistance
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Pathophysiology of Cerebral Gliomas: Towards Development of New Treatments submission deadline 15 Jun 2024 | 5 articles | Viewed by 6965 | Submission Open
Keywords: gliomas pathophysiology; biomarkers; microenvironment; cancer stem cells; brain resident cells; omics approaches; preclinical models; targeted treatment; brain drug delivery
(This special issue belongs to the Section Molecular Neurobiology)
New Advances in Type 2 Diabetes and Its Complications
edited by
submission deadline 15 Jun 2024 | 3 articles | Viewed by 6393 | Submission Open
Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms and Therapies of Lung Cancer
edited by and Marek Kimmel
submission deadline 15 Jun 2024 | 4 articles | Viewed by 6346 | Submission Open
Keywords: lung cancer; molecular mechanisms; multiomic data; mathematical modeling; molecular therapies
(This special issue belongs to the Section Molecular Oncology)
Genetic Variability and Molecular Evolution of SARS-CoV-2 submission deadline 15 Jun 2024 | 5 articles | Viewed by 6193 | Submission Open
Keywords: SARS-CoV-2 phylogenomics; genetics; molecular epidemiology
(This special issue belongs to the Section Biochemistry)
Plant Defense-Related Genes and Their Networks
edited by
submission deadline 15 Jun 2024 | 4 articles | Viewed by 6143 | Submission Open
Keywords: defence-related gene; defence-responsive genes; disease resistance; plant-pathogen interaction; plant immunity; protein modification; transcriptional profiling
(This special issue belongs to the Section Molecular Genetics and Genomics)
Human Immunodeficiency Virus-1 Infection: Molecular and Cellular Immunity
edited by
submission deadline 15 Jun 2024 | 4 articles | Viewed by 5823 | Submission Open
Keywords: HIV; PLWH; innate immunity; adaptive immunity; HIV controllers; HIV reservoir; non-AIDS events
(This special issue belongs to the Section Molecular Immunology)
Molecular Probe: Recent Research and Future Challenges submission deadline 15 Jun 2024 | 4 articles | Viewed by 5808 | Submission Open
Keywords: molecular imaging; radiotracer; probes; nanoparticles; diagnosis
(This special issue belongs to the Section Biochemistry)
Current Research in Pharmacognosy: A Focus on Biological Activities
edited by , , Artur Figueirinha and
submission deadline 15 Jun 2024 | 3 articles | Viewed by 5191 | Submission Open
Keywords: phytochemical characterization; volatile biomolecules; polyphenols; anticancer; anti-inflammatory; antimicrobial; antioxidant; synergism; toxicity
(This special issue belongs to the Section Molecular Pharmacology)
Innovative Strategies in the Development of Antivirals and Vaccines submission deadline 15 Jun 2024 | 2 articles | Viewed by 4609 | Submission Open
Keywords:   antivirals;   vaccines;   viruses;   innate immunity;   adaptive immunity;   viral replication;   antibodies;   immunological memory;   B and T cells
(This special issue belongs to the Section Molecular Microbiology)
Advances in Tomato Breeding and Molecular Research
edited by Silvana Grandillo, and
submission deadline 15 Jun 2024 | 5 articles | Viewed by 4337 | Submission Open
Keywords: tomato; natural and induced variation; genetics; genomics; omics; molecular breeding; physiology and development; fruit quality; biochemistry and metabolism; biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Insights on the Role of Stem Cells in Tendon Tissue Engineering: From Basic Science to Translational Medicine submission deadline 15 Jun 2024 | 4 articles | Viewed by 4222 | Submission Open
Keywords: stem cells; tenogenic differentiation; 3D in vitro tendon models; immunomodulation; biomimetic scaffolds; in vivo tendon models; dynamic cultures
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Therapies for Glioblastoma submission deadline 15 Jun 2024 | 3 articles | Viewed by 4119 | Submission Open
Keywords: glioblastoma; drug repurposing; drug delivery; biomaterials; immunotherapy; immune checkpoint inhibitors; oncolytic virotherapy; CAR-T cells; dendritic cell vaccination; spherical nucleic acids; gene therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Gut Microbiota and Intestinal Diseases submission deadline 15 Jun 2024 | 3 articles | Viewed by 3603 | Submission Open
Keywords: dysbiosis; homeostasis; intestinal disease; bioactive molecules; gut health
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Experimental and Clinical Aspects of Allergies and Autoimmunity submission deadline 15 Jun 2024 | 3 articles | Viewed by 3491 | Submission Open
Keywords: advanced diagnostics; extracellular vesicles; hypersensitivity; immune regulation; long noncoding RNA; miRNA; novel therapeutics; research models of allergy and autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Molecular Research of Biomedical X-ray Fluorescence Imaging (XFI)
edited by Florian Grüner
submission deadline 15 Jun 2024 | 3 articles | Viewed by 3445 | Submission Open
Keywords: X-ray fluorescence imaging; biomedical imaging; pharmacokinetics; drug development; non-desctructing testing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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