Proceedings of the 12th Alcohol Hangover Research Group Meeting, in Buenos Aires, Argentina †
Abstract
:1. Introduction
2. Functional Consequences and Cognition
3. Mood
4. Pathology and Treatment
5. COVID-19
6. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- World Health Organization. Alcohol, Total per Capita (15+) Consumption (in Litres of Pure Alcohol) (SDG Indicator 3.5.2). Available online: https://www.who.int/data/gho/data/indicators/indicator-details/GHO/total-(recorded-unrecorded)-alcohol-per-capita-(15-)-consumption (accessed on 6 January 2024).
- Verster, J.C.; Van Herwijnen, J.; Olivier, B.; Kahler, C.W. Validation of the Dutch Brief Young Adult Alcohol Consequences Questionnaire (B-YAACQ). Addict. Behav. 2009, 34, 411–414. [Google Scholar] [CrossRef]
- Verster, J.C.; Scholey, A.; van de Loo, A.J.A.E.; Benson, S.; Stock, A.-K. Updating the definition of the alcohol hangover. J. Clin. Med. 2020, 9, 823. [Google Scholar] [CrossRef] [PubMed]
- Verster, J.C.; Arnoldy, L.; Benson, S.; Scholey, A.; Stock, A.-K. The Alcohol Hangover Research Group: Ten Years of Progress in Research on the Causes, Consequences, and Treatment of the Alcohol Hangover. J. Clin. Med. 2020, 9, 3670. [Google Scholar] [CrossRef] [PubMed]
- Hendriksen, P.A.; Kiani, P.; Merlo, A.; Karadayian, A.; Czerniczyniec, A.; Lores-Arnaiz, S.; Bruce, G.; Verster, J.C. The COLIBAS study—COVID-19 lockdown effects on mood, academic functioning, alcohol consumption, and perceived immune fitness: Data from Buenos Aires university students. Data 2022, 7, 131. [Google Scholar] [CrossRef]
- Hendriksen, P.A.; Merlo, A.; Garssen, J.; Bijlsma, E.Y.; Engels, F.; Bruce, G.; Verster, J.C. The impact of COVID-19 lockdown on academic functioning and mood: Data from Dutch pharmacy students, PhD candidates and post-docs. Data 2021, 6, 120. [Google Scholar] [CrossRef]
- Koyun, A.H.; Hendriksen, P.A.; Kiani, P.; Merlo, A.; Balikji, J.; Stock, A.-K.; Verster, J.C. COVID-19 lockdown effects on mood, alcohol consumption, academic functioning, and perceived immune fitness: Data from young adults in Germany. Data 2022, 7, 125. [Google Scholar] [CrossRef]
- Verster, J.C.; Stephens, R. The importance of raising the profile of alcohol hangover research. Curr. Drug Abuse Rev. 2010, 3, 64–67. [Google Scholar]
- Verster, J.C.; Stephens, R.; Penning, R.; Rohsenow, D.; McGeary, J.; Levy, D.; McKinney, A.; Finnigan, F.; Piasecki, T.M.; Adan, A.; et al. The Alcohol Hangover Research Group consensus statement on best practice in alcohol hangover research. Curr. Drug Abuse Rev. 2010, 3, 116–127. [Google Scholar] [CrossRef] [PubMed]
- Verster, J.C.; Kruisselbrink, L.D.; Slot, K.A.; Anogeianaki, A.; Adams, S.; Alford, C.; Arnoldy, L.; Ayre, E.; Balikji, S.; Benson, S.; et al. Sensitivity to experiencing alcohol hangovers: Reconsideration of the 0.11% blood alcohol concentration (BAC) threshold for having a hangover. J. Clin. Med. 2020, 9, 179. [Google Scholar] [CrossRef]
- Van Schrojenstein Lantman, M.; Mackus, M.; van de Loo, A.J.A.E.; Verster, J.C. Development of a definition for the alcohol hangover: Consumer descriptions and expert consensus. Curr. Drug Abuse Rev. 2016, 9, 148–154. [Google Scholar] [CrossRef]
- Gunn, C.; Mackus, M.; Griffin, C.; Munafò, M.R.; Adams, S. A systematic review of the next-day effects of heavy alcohol consumption on cognitive performance. Addiction 2018, 113, 2182–2193. [Google Scholar] [CrossRef]
- Frone, M.R. Alcohol and Illicit Drug Use in the Workforce and Workplace; American Psychological Association: Washington, DC, USA, 2013. [Google Scholar] [CrossRef]
- Bhattacharya, A. Financial Headache. The Cost of Workplace Hangovers and Intoxication to the UK Economy; IAS: London, UK, 2019; Available online: http://www.ias.org.uk/uploads/pdf/IAS%20reports/rp35062019.pdf (accessed on 5 October 2020).
- Kiani, P.; Merlo, A.; Saeed, H.M.; Benson, S.; Bruce, G.; Hoorn, R.; Kraneveld, A.D.; Severeijns, N.R.; Sips, A.S.M.; Scholey, A.; et al. Immune fitness, and the psychosocial and health consequences of the COVID-19 pandemic lockdown in The Netherlands: Methodology and design of the CLOFIT study. Eur. J. Investig. Health Psychol. Educ. 2021, 11, 199–218. [Google Scholar] [CrossRef] [PubMed]
- Severeijns, N.R.; Sips, A.S.M.; Merlo, A.; Bruce, G.; Verster, J.C. Absenteeism, presenteeism, and the economic costs of alcohol hangover in the Netherlands. Healthcare 2024, 12, 335. [Google Scholar] [CrossRef] [PubMed]
- Devenney, L.E.; Coyle, K.B.; Roth, T.; Verster, J.C. Sleep after heavy alcohol consumption and physical activity levels during alcohol hangover. J. Clin. Med. 2019, 8, 752. [Google Scholar] [CrossRef] [PubMed]
- Devenney, L.E.; Stock, A.-K.; Merlo, A.; Hendriksen, P.A.; Gunn, C.A.; Opitz, A.; Bruce, G.; Verster, J.C. Proceedings of the first Irish Alcohol Hangover Research Seminar. Proceedings 2022, 80, 5. [Google Scholar]
- De Santis, S.; Sommer, W.H.; Canals, S. Detecting Alcohol-Induced Brain Damage Noninvasively Using Diffusion Tensor Imaging. ACS Chem. Neurosci. 2019, 10, 4187–4189. [Google Scholar] [CrossRef] [PubMed]
- Harburg, E.; Davis, D.; Cummings, K.M.; Gunn, R. Negative affect, alcohol consumption and hangover symptoms among normal drinkers in a small community. J. Stud. Alcohol 1981, 42, 998–1012. [Google Scholar] [CrossRef]
- Harburg, E.; Gunn, R.; Gleiberman, L.; DiFranceisco, W.; Schork, A. Psychosocial factors, alcohol use, and hangover signs among social drinkers: A reappraisal. J. Clin. Epidemiol. 1993, 46, 413–422. [Google Scholar] [CrossRef] [PubMed]
- Verster, J.C.; Arnoldy, L.; van de Loo, A.J.A.E.; Benson, S.; Scholey, A.; Stock, A.-K. The impact of mood and subjective intoxication on hangover severity. J. Clin. Med. 2020, 9, 2462. [Google Scholar] [CrossRef]
- Terpstra, C.; Verster, J.C.; Scholey, A.; Benson, S. Associations between mental resilience, mood, coping, personality, and hangover severity. J. Clin. Med. 2022, 11, 2240. [Google Scholar] [CrossRef]
- Van de Loo, A.J.A.E.; van Schrojenstein Lantman, M.; Mackus, M.; Scholey, A.; Verster, J.C. Impact of mental resilience and perceived immune functioning on the severity of alcohol hangover. BMC Res. Notes 2018, 11, 526. [Google Scholar] [CrossRef]
- Van Schrojenstein Lantman, M.; van de Loo, A.J.A.E.; Mackus, M.; Brookhuis, K.A.; Kraneveld, A.D.; Garssen, J.; Verster, J.C. Susceptibility to alcohol hangovers: Not just a matter of being resilient. Alcohol Alcohol. 2018, 53, 241–244. [Google Scholar] [CrossRef]
- Verster, J.C.; Donders, J.A.; Boogaard, A.S.; Bruce, G. Predictors of hangover frequency and severity: The impact of alcohol consumption, mental resilience, personality, lifestyle, coping and mood. J. Clin. Med. 2023, 12, 3811. [Google Scholar] [CrossRef]
- Verster, J.C.; van de Loo, A.J.A.E.; Benson, S.; Scholey, A.; Stock, A.-K. The assessment of overall hangover severity. J. Clin. Med. 2020, 9, 786. [Google Scholar] [CrossRef] [PubMed]
- Smith, B.; Dalen, J.; Wiggins, K.; Tooley, E.; Christopher, P.; Bernard, J. The Brief Resilience Scale: Assessing the ability to bounce back. Int. J. Behav. Med. 2008, 15, 194–200. [Google Scholar] [CrossRef] [PubMed]
- Sanderman, R.; Arrindell, W.A.; Ranchor, A.V.; Eysenck, H.J.; Eysenck, S.B.G. Het Meten van Persoonlijkheidskenmerken Met de Eysenck Personality Questionnaire (EPQ), Een Handleiding; Tweede Herziene Druk; UMCG/Rijksuniversiteit Groningen, Research Institute SHARE: Groningen, The Netherlands, 2012. [Google Scholar]
- Verster, J.C.; Sandalova, E.; Garssen, J.; Bruce, G. The use of single-item ratings versus traditional multiple-item questionnaires to assess mood and health. Eur. J. Investig. Health Psychol. Educ. 2021, 11, 15. [Google Scholar] [CrossRef] [PubMed]
- Devynck, F.; Rousseau, A.; Romo, L. Does repetitive negative thinking influence alcohol use? A systematic review of the literature. Front. Psychol. 2019, 10, 1482. [Google Scholar] [CrossRef] [PubMed]
- Sloan, E.; Hall, K.; Moulding, R.; Bryce, S.; Mildred, H.; Staiger, P.K. Emotion regulation as a transdiagnostic treatment construct across anxiety, depression, substance, eating and borderline personality disorders: A systematic review. Clin. Psychol. Rev. 2017, 57, 141–163. [Google Scholar] [CrossRef] [PubMed]
- Liverant, G.I.; Kamholz, B.W.; Sloan, D.M.; Brown, T.A. Rumination in clinical depression: A type of emotional suppression? Cogn. Ther. Res. 2010, 35, 253–265. [Google Scholar] [CrossRef]
- Watkins, E.R.; Roberts, H. Reflecting on rumination: Consequences, causes, mechanisms and treatment of rumination. Behav. Res. Ther. 2020, 127, 103573. [Google Scholar] [CrossRef] [PubMed]
- Berking, M.; Margraf, M.; Ebert, D.; Wupperman, P.; Hofmann, S.G.; Junghanns, K. Deficits in emotion-regulation skills predict alcohol use during and after cognitive–behavioral therapy for alcohol dependence. J. Consult. Clin. Psychol. 2011, 79, 307–318. [Google Scholar] [CrossRef]
- Tellez-Monnery, K.; Berghoff, C.R.; McDermott, M.J. Investigating the effects of emotion dysregulation and repetitive negative thinking on alcohol hangover anxiety and depression. Addict. Behav. 2023, 140, 107619. [Google Scholar] [CrossRef]
- Tipple, C.; Benson, S.; Scholey, A. A review of the physiological factors associated with an alcohol-induced hangover. Curr. Drug Abuse Rev. 2017, 9, 93–98. [Google Scholar] [CrossRef] [PubMed]
- Palmer, E.; Tyacke, R.; Sastre, M.; Lingford-Hughes, A.; Nutt, D.; Ward, R.J. Alcohol hangover: Underlying biochemical, inflammatory and neurochemical mechanisms. Alcohol Alcohol. 2019, 54, 196–203. [Google Scholar] [CrossRef] [PubMed]
- Mackus, M.; van de Loo, A.J.E.A.; Garssen, J.; Kraneveld, A.D.; Scholey, A.D.; Verster, J.C. The role of alcohol metabolism in the pathology of alcohol hangover. J. Clin. Med. 2020, 9, 3421. [Google Scholar] [CrossRef] [PubMed]
- Mackus, M.; van de Loo, A.J.E.A.; Garssen, J.; Kraneveld, A.D.; Scholey, A.; Verster, J.C. The association between ethanol elimination rate and hangover severity. Int. J. Environ. Res. Public Health 2020, 17, 4324. [Google Scholar] [CrossRef] [PubMed]
- Van de Loo, A.J.A.E.; Mackus, M.; Kwon, O.; Krishnakumar, I.; Garssen, J.; Kraneveld, A.D.; Scholey, A.; Verster, J.C. The inflammatory response to alcohol consumption and its role in the pathology of alcohol hangover. J. Clin. Med. 2020, 9, 2081. [Google Scholar] [CrossRef] [PubMed]
- Van de Loo, A.J.A.E.; Raasveld, S.J.; Hogewoning, A.; de Zeeuw, R.; Bosma, E.R.; Bouwmeester, N.H.; Lukkes, M.; Knipping, K.; Mackus, M.; Kraneveld, A.D.; et al. Immune responses after heavy alcohol consumption: Cytokine concentrations in hangover sensitive and hangover resistant drinkers. Healthcare 2021, 9, 395. [Google Scholar] [CrossRef] [PubMed]
- Verster, J.C.; van Rossum, C.J.I.; Scholey, A. Unknown safety and efficacy of alcohol hangover treatments puts consumers at risk. Addictive Behav. 2021, 122, 107029. [Google Scholar] [CrossRef]
- Verster, J.C.; van Rossum, C.J.I.; Lim, Y.N.; Kwon, O.; Scholey, A.P. The effect of dihydromyricetin (DHM) from hovenia dulcis extract on alcohol hangover severity. In Proceedings of the European Neuropsychopharmacology: 34th ECNP Congress (Lisbon 2021), Hybrid, Lisbon, Portugal, 2–5 October 2021; Volume 53 Suppl. 1, pp. S224–S225. [Google Scholar] [CrossRef]
- Renis, M.; Calabrese, V.; Russo, A.; Calderone, A.; Barcellona, M.L.; Rizza, V. Nuclear DNA strand breaks during ethanol-induced oxidative stress in rat brain. FEBS Lett. 1996, 390, 153–156. [Google Scholar] [CrossRef] [PubMed]
- Bustamante, J.; Karadayian, A.G.; Lores Arnaiz, S.; Cutrera, R.A. Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover. Alcohol 2012, 46, 473–479. [Google Scholar] [CrossRef] [PubMed]
- Karadayian, A.G.; Busso, M.J.; Feleder, C.; Cutrera, R.A. Alterations in affective behavior during the time course of alcohol hangover. Behav. Brain Res. 2013, 253, 128–138. [Google Scholar] [CrossRef] [PubMed]
- Karadayian, A.G.; Cutrera, R.A. Alcohol hangover: Type and time-extension of motor function impairments. Behav. Brain Res. 2013, 247, 165–173. [Google Scholar] [CrossRef] [PubMed]
- Karadayian, A.G.; Mac Laughlin, M.A.; Cutrera, R.A. Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice. Physiol. Behav. 2012, 107, 181–186. [Google Scholar] [CrossRef] [PubMed]
- Karadayian, A.G.; Lores-Arnaiz, S.; Cutrera, R.A. The effect of constant darkness and circadian resynchronization on the recovery of alcohol hangover. Behav. Brain Res. 2014, 268, 94–103. [Google Scholar] [CrossRef]
- Karadayian, A.G.; Bustamante, J.; Czerniczyniec, A.; Lombardi, P.; Cutrera, R.A.; Lores-Arnaiz, S. Alcohol hangover induces mitochondrial dysfunction and free radical production in mouse cerebellum. Neuroscience 2015, 304, 47–59. [Google Scholar] [CrossRef]
- Lores-Arnaiz, S.; Rodríguez de Lores Arnaiz, G.; Karadayian, A.G.; Bustamante, J. Synaptosomes bioenergetics and calcium handling: Aging response. In Synaptosome Methods and Applications; Murphy, K.M., Ed.; Springer Protocols Neuromethods Series; Humana Press: New York, NY, USA, 2018; pp. 131–151. [Google Scholar]
- Nicholls, D.G. Stochastic aspects of transmitter release and bioenergetic dysfunction in isolated nerve terminals. Biochem. Soc. Trans. 2010, 38, 457–459. [Google Scholar] [CrossRef]
- Lores-Arnaiz, S.; Lombardi, P.; Karadayian, A.G.; Orgambide, F.; Cicerchia, D.; Bustamante, J. Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem. Res. 2016, 41, 353–363. [Google Scholar] [CrossRef]
- Lores-Arnaiz, S.; Lombardi, P.; Karadayian, A.G.; Cutrera, R.; Bustamante, J. Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice. Exp. Gerontol. 2019, 118, 88–98. [Google Scholar] [CrossRef]
- Karadayian, A.G.; Bustamante, J.; Czerniczyniec, A.; Cutrera, R.A.; Lores-Arnaiz, S. Effect of melatonin on motor performance and brain cortex mitochondrial function during ethanol hangover. Neuroscience 2014, 269, 281–289. [Google Scholar] [CrossRef]
- Karadayian, A.G.; Malanga, G.; Czerniczyniec, A.; Lombardi, P.; Bustamante, J.; Lores-Arnaiz, S. Free radical production and antioxidant status in brain cortex non-synaptic mitochondria and synaptosomes at alcohol hangover onset. Free Radic. Biol. Med. 2017, 108, 692–703. [Google Scholar] [CrossRef]
- Karadayian, A.G.; Lombardi, P.; Bustamante, J.; Lores-Arnaiz, S. Alcohol hangover effects on brain cortex non-synaptic mitochondria and synaptosomes bioenergetics. Alcohol 2019, 77, 113–123. [Google Scholar] [CrossRef]
- Karadayian, A.G.; Bustamante, J.; Lores-Arnaiz, S. Alcohol hangover induces nitric oxide metabolism changes by impairing NMDA receptor-PSD95-nNOS pathway. Nitric Oxide 2021, 113–114, 39–49. [Google Scholar] [CrossRef]
- Yokoyama, M.; Yokoyama, A.; Yokoyama, T.; Funazu, K.; Hamana, G.; Kondo, S.; Yamashita, T.; Nakamura, H. Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers. Alcohol Clin. Exp. Res. 2005, 29, 1165–1171. [Google Scholar] [CrossRef]
- Wall, T.L.; Horn, S.M.; Johnson, M.L.; Smith, T.L.; Carr, L.G. Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. J. Stud. Alcohol 2000, 61, 13–17. [Google Scholar] [CrossRef]
- Slutske, W.S.; Piasecki, T.M.; Nathanson, L.; Statham, D.J.; Martin, N.G. Genetic influences on alcohol-related hangover. Addiction 2014, 109, 2027–2034. [Google Scholar] [CrossRef]
- Wu, S.H.; Guo, Q.; Viken, R.J.; Reed, T.; Dai, J. Heritability of usual alcohol intoxication and hangover in male twins: The NAS-NRC Twin Registry. Alcohol Clin. Exp. Res. 2014, 38, 2307–2313. [Google Scholar] [CrossRef] [PubMed]
- Olugemo, K.; Bugarski-Kirola, D.; Dawson, G.R.; DiCesare, F.; Stevanović, D.; Samardzic, J.; Chatzittofis, A.; Moore, R.; Verster, J.C.; Bhering, L.; et al. Conducting CNS trials during a public health emergency—Lessons learned from the COVID-19 pandemic: A joint ISCTM/ECNP working group consensus paper. Neurosci. Applied. 2023, 2, 101129. [Google Scholar] [CrossRef]
- Merlo, A.; Hendriksen, P.A.; Garssen, J.; Bijlsma, E.Y.; Engels, F.; Bruce, G.; Verster, J.C. Transition to online education during the COVID-19 pandemic: Impact of changes in alcohol consumption and experiencing hangovers on academic functioning. J. Clin. Med. 2021, 10, 5332. [Google Scholar] [CrossRef] [PubMed]
- Karadayian, A.; Merlo, A.; Czerniczyniec, A.; Lores-Arnaiz, S.; Hendriksen, P.A.; Kiani, P.; Bruce, G.; Verster, J.C. Alcohol consumption, hangovers, and smoking among Buenos Aires university students during the COVID-19 pandemic. J. Clin. Med. 2023, 12, 1491. [Google Scholar] [CrossRef] [PubMed]
- Slutske, W.S.; Piasecki, T.M.; Hunt-Carter, E.E. Development and initial validation of the hangover symptoms scale: Prevalence and correlates of hangover symptoms in college students. Alcohol Clin. Exp. Res. 2003, 27, 1442–1450. [Google Scholar] [CrossRef] [PubMed]
- Penning, R.; McKinney, A.; Bus, L.D.; Olivier, B.; Slot, K.; Verster, J.C. Measurement of alcohol hangover severity: Development of the Alcohol Hangover Severity Scale (AHSS). Psychopharmacology 2013, 225, 803–810. [Google Scholar] [CrossRef] [PubMed]
- Rohsenow, D.J.; Howland, J.; Minsky, S.J.; Greece, J.; Almeida, A.; Roehrs, T.A. The acute hangover scale: A new measure of immediate hangover symptoms. Addict. Behav. 2007, 32, 1314–1320. [Google Scholar] [CrossRef]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Tellez-Monnery, K.; Balikji, J.; Carrere, L.; Czerniczyniec, A.; Devenney, L.E.; Guerra, J.I.; Kiani, P.; Lores-Arnaiz, S.; Merlo, A.; Stock, A.-K.; et al. Proceedings of the 12th Alcohol Hangover Research Group Meeting, in Buenos Aires, Argentina. Proceedings 2024, 95, 1. https://doi.org/10.3390/proceedings2024095001
Tellez-Monnery K, Balikji J, Carrere L, Czerniczyniec A, Devenney LE, Guerra JI, Kiani P, Lores-Arnaiz S, Merlo A, Stock A-K, et al. Proceedings of the 12th Alcohol Hangover Research Group Meeting, in Buenos Aires, Argentina. Proceedings. 2024; 95(1):1. https://doi.org/10.3390/proceedings2024095001
Chicago/Turabian StyleTellez-Monnery, Kristin, Jessica Balikji, Lautaro Carrere, Analia Czerniczyniec, Lydia E. Devenney, Juan I. Guerra, Pantea Kiani, Silvia Lores-Arnaiz, Agnese Merlo, Ann-Kathrin Stock, and et al. 2024. "Proceedings of the 12th Alcohol Hangover Research Group Meeting, in Buenos Aires, Argentina" Proceedings 95, no. 1: 1. https://doi.org/10.3390/proceedings2024095001