Systematic Review and Meta-Analysis of Chicory Inulin-Type Fructans Supplementation on Weight Management Aspects †
BENEO Institute c/o BENEO GmbH, 67283 Obrigheim/Pfalz, Germany
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Author to whom correspondence should be addressed.
†
Presented at the 14th European Nutrition Conference FENS 2023, Belgrade, Serbia, 14–17 November 2023.
Proceedings 2023, 91(1), 155; https://doi.org/10.3390/proceedings2023091155
Published: 1 February 2024
(This article belongs to the Proceedings of The 14th European Nutrition Conference FENS 2023)
Abstract
:Maintaining and reducing weight are considered as important features in reducing mortality and morbidity caused by metabolic-associated diseases. Increasing evidence from in vivo mechanistic and clinical studies has shown that the gut microbiota is interacting with the host's physiological function in regulating energy intake and body weight. A prebiotic is a substrate that is selectively utilized by host microorganisms conferring a health benefit. Numerous clinical studies showed multifaceted benefits of prebiotic chicory inulin-type fructans (ITFs) on gut and metabolic health. The present systematic review and meta-analysis aimed to synthesize the totality of evidence through pooled estimates of ITF supplementation in supporting weight management on both healthy and diseased subjects. A systematic search for eligible articles was performed in databases (EMBASE, MEDLINE (PubMed), Web of Science) without a language restriction. Two reviewers independently extracted data from eligible articles. We chose primary (body weight) and secondary (BMI, total fat mass, body fat percentage and waist circumference) outcomes as weight management parameters. The baseline-corrected mean difference (MD) was used to synthesize the pooled effect size by employing a random-effects model using the inverse variance method. A sub-group analysis based on dose, duration, health status and ITF-type was also conducted. A total of 31 randomized controlled trials with 40 arms (n = 1309 participants) were included in this review. A significant reduction was observed on body weight (MD: −1.03 kg, 95% CI: −1.42 to −0.64, p < 0.0001), BMI (MD: −0.39 kg/m2, 95% CI: −0.58 to −0.21, p = 0.0001), fat mass (MD: −0.45 kg, 95% CI: −0.71 to −0.2, p = 0.0023), and waist circumference (MD: −0.99 cm, 95% CI: −1.61 to −0.37, p = 0.003) following ITF supplementation. For body fat percentage, a significant effect was observed following subgroup analysis on an intervention that lasted for more than 8 weeks (MD: −0.78 percent, 95% CI: −1.17 to −0.39, p < 0.01). The present meta-analysis of randomized controlled trials provides further evidence to support that ITF supplementation could help benefit weight management by reducing body weight, BMI, fat mass, waist circumference, and to a certain extent on body fat percentage.
Author Contributions
Conceptualization, Y.C.Z. and S.T.; methodology, Y.C.Z.; software, Y.C.Z.; validation, Y.C.Z. and S.T.; formal analysis, Y.C.Z.; investigation, Y.C.Z. and S.T.; resources, S.T.; data curation, Y.C.Z. and S.T.; writing—original draft preparation, Y.C.Z.; writing—review and editing, Y.C.Z. and S.T.; visualization, Y.C.Z.; supervision, S.T.; project administration, Y.C.Z. and S.T.; funding acquisition, S.T. All authors have read and agreed to the published version of the manuscript.
Funding
The present work was conducted as part of the overall scientific work of Y.C.Z. and S.T. as employees of BENEO/Südzucker Group and did not receive any specific grant/research funding.
Institutional Review Board Statement
Not applicable.
Informed Consent Statement
The present study is a systematic review and meta-analysis, therefore ethics approval is not required.
Data Availability Statement
The review was conducted using already published data.
Conflicts of Interest
Y.C.Z. and S.T. are employees of BENEO/Südzucker Group, Germany. BENEO is a company involved in production of food ingredients including prebiotic fructans and polyols.
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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MDPI and ACS Style
Zanzer, Y.C.; Theis, S. Systematic Review and Meta-Analysis of Chicory Inulin-Type Fructans Supplementation on Weight Management Aspects. Proceedings 2023, 91, 155. https://doi.org/10.3390/proceedings2023091155
AMA Style
Zanzer YC, Theis S. Systematic Review and Meta-Analysis of Chicory Inulin-Type Fructans Supplementation on Weight Management Aspects. Proceedings. 2023; 91(1):155. https://doi.org/10.3390/proceedings2023091155
Chicago/Turabian StyleZanzer, Yoghatama Cindya, and Stephan Theis. 2023. "Systematic Review and Meta-Analysis of Chicory Inulin-Type Fructans Supplementation on Weight Management Aspects" Proceedings 91, no. 1: 155. https://doi.org/10.3390/proceedings2023091155
