Inflammaging: The Immunology of Aging

Dear Colleagues,

Several factors contribute to the aging process. These factors include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication. Together, these are referred to as “the Hallmarks of Aging”. A characteristic feature of altered intercellular communication is inflammaging or age-related inflammation. Dysregulation of the innate and/or adaptive immune response contributes to inflammaging, which is believed to be a predecessor to the development of age-related diseases such as Alzheimer’s disease, Parkinson’s disease, age-related macular degeneration, obesity, type 2 diabetes and atherosclerosis, among others. We invite all scientists working on the immunology of age-related conditions or diseases to participate in this Topic. Original research articles, reviews, or shorter perspective articles on all aspects related to the immunology of aging and age-related processes are welcome. Articles with insights from a cell and molecular biological perspective are especially welcome. Relevant topics include but are not limited to: inflammaging and oxidative stress, age-related cardiovascular diseases, the role of extracellular vesicle biology in inflammaging, inflammasome regulation in aging and age-related diseases, inflammation and neurodegeneration, inflammation and joint degeneration, inflammaging and the gut microbiome, and inflammaging and cancer.

Dr. Juan Pablo de Rivero Vaccari
Dr. Alejandro Martín-Montalvo
Topic Editors