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Pharmaceutics
Special Issues
Biopolymers for Biomedical and Pharmaceutical Applications
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Biopolymers for Biomedical and Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 4846

Special Issue Editors

Dr. Magdalena Stevanović

E-Mail Website
Guest Editor
Institute of Technical Sciences of SASA, Kneza Mihaila 35/IV, 11000 Belgrade, Serbia
Interests: biomaterials, controlled drug delivery; nanomaterials; nanomedicine; biomedical research; synthesis and characterization of biocompatible micro and nanoparticles; tissue engineering
Dr. Nenad Filipovic

E-Mail Website
Guest Editor
Institute of Technical Sciences of SASA, Kneza Mihaila 35/IV, 11000 Belgrade, Serbia
Interests: biomaterials; biodegradable polymers; controlled release of active components; tissue engineering; nanomedicine; synthesis and characterization of micro/nano particles; understanding the interaction of biomaterials with biological entities

Special Issue Information

Dear Colleagues,

The main goal of this Special Issue is to provide a comprehensive collection of the most recent advances in research related to the biopolymers, either natural or synthetic, as well as their applications in medical and pharmaceutical fields. Biopolymers and their composites attract special attention due to their unique properties, biocompatibility, versatility, and flexible nature. Thus, its potential application is constantly expanding. Biopolymers can be prepared into various forms such as micro/nanoparticles, 3D scaffolds, hydrogels, and films, or they can be combined with other materials (composites) depending on the application demands. This Special Issue on biopolymers used for medical and pharmaceutical applications will bring together experts from materials science, chemistry, biology, pharmacy, medicine, physics, nanotechnology, etc., to review the current state of the art and to express outstanding research needs related to this topic. Types of manuscripts to be featured include reviews, original research articles, and perspectives. Multidisciplinary research relating to advances in the production, characterization, and applications of biopolymers, as well as the design of effective drug delivery systems, tissue engineering, wound healing, cell therapy, and other themes not limited to this, is welcomed.

We look forward to receiving your contributions.

Dr. Magdalena Stevanović
Dr. Nenad Filipovic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • formulations, engineering, functionalization
  • biotechnology, nanotechnology, nanomedicine
  • drug design/delivery/targeting
  • tissue engineering and repairing
  • cell culture/therapy
  • wound healing/dressing
  • coatings
  • medical devices
  • biocompatibility
  • biodegradation

Published Papers (3 papers)

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Research

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25 pages, 27127 KiB  
Article
Nanogallium-poly(L-lactide) Composites with Contact Antibacterial Action
by Mario Kurtjak, Marjeta Maček Kržmanc, Matjaž Spreitzer and Marija Vukomanović
Pharmaceutics 2024, 16(2), 228; https://doi.org/10.3390/pharmaceutics16020228 - 4 Feb 2024
Viewed by 1349
Abstract
In diverse biomedical and other applications of polylactide (PLA), its bacterial contamination and colonization are unwanted. For this reason, this biodegradable polymer is often combined with antibacterial agents or fillers. Here, we present a new solution of this kind. Through the process of [...] Read more.
In diverse biomedical and other applications of polylactide (PLA), its bacterial contamination and colonization are unwanted. For this reason, this biodegradable polymer is often combined with antibacterial agents or fillers. Here, we present a new solution of this kind. Through the process of simple solvent casting, we developed homogeneous composite films from 28 ± 5 nm oleic-acid-capped gallium nanoparticles (Ga NPs) and poly(L-lactide) and characterized their detailed morphology, crystallinity, aqueous wettability, optical and thermal properties. The addition of Ga NPs decreased the ultraviolet transparency of the films, increased their hydrophobicity, and enhanced the PLA structural ordering during solvent casting. Albeit, above the glass transition, there is an interplay of heterogeneous nucleation and retarded chain mobility through interfacial interactions. The gallium content varied from 0.08 to 2.4 weight %, and films with at least 0.8% Ga inhibited the growth of Pseudomonas aeruginosa PAO1 in contact, while 2.4% Ga enhanced the effect of the films to be bactericidal. This contact action was a result of unwrapping the top film layer under biological conditions and the consequent bacterial contact with the exposed Ga NPs on the surface. All the tested films showed good cytocompatibility with human HaCaT keratinocytes and enabled the adhesion and growth of these skin cells on their surfaces when coated with poly(L-lysine). These properties make the nanogallium-polyl(L-lactide) composite a promising new polymer-based material worthy of further investigation and development for biomedical and pharmaceutical applications. Full article
(This article belongs to the Special Issue Biopolymers for Biomedical and Pharmaceutical Applications)
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Review

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38 pages, 8003 KiB  
Review
A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years
by Magdalena Stevanović and Nenad Filipović
Pharmaceutics 2024, 16(5), 670; https://doi.org/10.3390/pharmaceutics16050670 - 16 May 2024
Viewed by 516
Abstract
In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These systems offer promising strategies for targeted and controlled drug delivery while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, [...] Read more.
In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These systems offer promising strategies for targeted and controlled drug delivery while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, the healthcare landscape is constantly evolving, necessitating the continual development of innovative therapeutic approaches and drug delivery systems (DDSs). DDSs play a pivotal role in enhancing treatment efficacy, minimizing adverse effects, and optimizing patient compliance. Among these, nanotechnology-driven delivery approaches have garnered significant attention due to their unique properties, such as improved solubility, controlled release, and targeted delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., offer versatile platforms for drug delivery and tissue engineering applications. Additionally, biopolymer-based DDSs hold immense promise, leveraging natural or synthetic biopolymers to encapsulate drugs and enable targeted and controlled release. These systems offer numerous advantages, including biocompatibility, biodegradability, and low immunogenicity. The utilization of polysaccharides, polynucleotides, proteins, and polyesters as biopolymer matrices further enhances the versatility and applicability of DDSs. Moreover, substances with antioxidative properties have emerged as key players in combating oxidative stress-related diseases, offering protection against cellular damage and chronic illnesses. The development of biopolymer-based nanoformulations with antioxidative properties represents a burgeoning research area, with a substantial increase in publications in recent years. This review provides a comprehensive overview of the recent developments within this area over the past five years. It discusses various biopolymer materials, fabrication techniques, stabilizers, factors influencing degradation, and drug release. Additionally, it highlights emerging trends, challenges, and prospects in this rapidly evolving field. Full article
(This article belongs to the Special Issue Biopolymers for Biomedical and Pharmaceutical Applications)
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35 pages, 4010 KiB  
Review
Biopolymeric Prodrug Systems as Potential Antineoplastic Therapy
by Adriana Aurelia Chis, Anca Maria Arseniu, Claudiu Morgovan, Carmen Maximiliana Dobrea, Adina Frum, Anca Maria Juncan, Anca Butuca, Steliana Ghibu, Felicia Gabriela Gligor and Luca Liviu Rus
Pharmaceutics 2022, 14(9), 1773; https://doi.org/10.3390/pharmaceutics14091773 - 25 Aug 2022
Cited by 5 | Viewed by 2204
Abstract
Nowadays, cancer represents a major public health issue, a substantial economic issue, and a burden for society. Limited by numerous disadvantages, conventional chemotherapy is being replaced by new strategies targeting tumor cells. In this context, therapies based on biopolymer prodrug systems represent a [...] Read more.
Nowadays, cancer represents a major public health issue, a substantial economic issue, and a burden for society. Limited by numerous disadvantages, conventional chemotherapy is being replaced by new strategies targeting tumor cells. In this context, therapies based on biopolymer prodrug systems represent a promising alternative for improving the pharmacokinetic and pharmacologic properties of drugs and reducing their toxicity. The polymer-directed enzyme prodrug therapy is based on tumor cell targeting and release of the drug using polymer–drug and polymer–enzyme conjugates. In addition, current trends are oriented towards natural sources. They are biocompatible, biodegradable, and represent a valuable and renewable source. Therefore, numerous antitumor molecules have been conjugated with natural polymers. The present manuscript highlights the latest research focused on polymer–drug conjugates containing natural polymers such as chitosan, hyaluronic acid, dextran, pullulan, silk fibroin, heparin, and polysaccharides from Auricularia auricula. Full article
(This article belongs to the Special Issue Biopolymers for Biomedical and Pharmaceutical Applications)
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