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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolomics and Bioinformatics Approaches to Studying Human Gut Microbiota-Derived Metabolites

edited by Zhiwei Zhou, Shipei Xing and Xiaotao Shen

submission deadline 15 Apr 2026 | 2 articles | Viewed by 5613 | Submission Open

Keywords: metabolomics; bioinformatics; databases; gut microbiota; microbiome; host– microbe interaction; microbial metabolism; multiomics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Modulating Gut Microbiota and Host Interactions: The Role of Diet, Probiotics, and Circadian Rhythms

edited by Miri Park and Jeehwan Choe

submission deadline 15 Apr 2026 | 3 articles | Viewed by 3653 | Submission Open

Keywords: gut microbiota; diet and microbiome; probiotics; prebiotics; circadian rhythms; microbial metabolites; host– microbe interactions; nutritional strategies; gut– brain axis; metabolic health

(This special issue belongs to the Section Cell Metabolism)

Functional Foods and Natural Bioactive Compounds: Strategies to Face Metabolic Syndrome and Related Non-Communicable Diseases—2nd Edition

edited by

Paola Gauffin-Cano

, Sebastián Torres and

Roxana Medina

submission deadline 15 Apr 2026 | 1 articles | Viewed by 881 | Submission Open

Keywords: functional foods; bioactive compounds; fermented foods; fermented beverages; fermented vegetable foods; probiotics; prebiotics; synbiotics; postbiotics; metabolic syndrome; non-communicable diseases

Microbial Regulation of Host Metabolism

edited by

Kippeum Lee

submission deadline 15 Apr 2026 | 1 articles | Viewed by 650 | Submission Open

Keywords: gut microbiota-derived metabolites; short-chain fatty acids (SCFAs); gut hormones; bile acid; probi-otics; postbiotics; gut microbiota; microbiome; physiological function; metabolism balance

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Effects of Micronutrients on Human Metabolism

edited by

Lin Xiao

submission deadline 17 Apr 2026 | 1 articles | Viewed by 2131 | Submission Open

Keywords: micronutrients; trace minerals; vitamins; human metabolism; metabolic processes; obesity; diabetes; cardiovascular disease

(This special issue belongs to the Section Food Metabolomics)

Effects of Secondary Plant Metabolites on Human Health

edited by

Beáta Čižmárová

and

Anna Birková

submission deadline 17 Apr 2026 | 1 articles | Viewed by 1733 | Submission Open

Keywords: human health; inflammation; cancer; obesity; antioxidants; phytochemicals; phytoestrogens; secondary metabolites; natural products

(This special issue belongs to the Section Plant Metabolism)

The Multifaceted Roles of Biomarkers in Metabolic Disorders: From Diagnosis and Monitoring to Prediction, Management, and Treatment, 2nd Edition

edited by

Prince Dadson

and

Miikka-Juhani Honka

submission deadline 25 Apr 2026 | 1 articles | Viewed by 976 | Submission Open

Keywords: metabolism; dysmetabolism; tissue-specific metabolism; cardiometabolic disorders; nutritional disorders; functional biomarkers; metabolomics profiling; multi-omics data integration; biochemical pathways; personalized medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Modulators in Cardiovascular Disease Management

edited by

Syed Siraj A. Quadri

submission deadline 30 Apr 2026 | 4 articles | Viewed by 11939 | Submission Open

Keywords: metabolic modulators; cardiovascular therapeutics; mitochondrial function; cardiometabolic disorders; energy metabolism; metabolic syndrome; therapeutic targets; heart failure; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity

edited by

Joshua De Leon

submission deadline 30 Apr 2026 | 4 articles | Viewed by 9903 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders

edited by

Sylwia Dzięgielewska-Gęsiak

Teresa Grzelak

and Grzegorz Dziubanek

submission deadline 30 Apr 2026 | 3 articles | Viewed by 8392 | Submission Open

Keywords: nutritional attitudes and behaviors; bioconcentration factor; health risk assessment; dietary exposure; farm-fresh foods; medicinal plants; gut microbiota; dietary supplements; trace elements— Zn; Cu; heavy metals

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolite Profiling of Novel Psychoactive Substances

edited by

Jeremy Carlier

and Volker Auwärter

submission deadline 30 Apr 2026 | 3 articles | Viewed by 8085 | Submission Open

Keywords: new psychoactive substances; metabolism; case report; clinical toxicology; forensic toxicology

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Plant-Derived Molecules in Prevention of Metabolic and Oxidative Stress-Related Diseases

edited by Hicham Harnafi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 6346 | Submission Open

Keywords: lipid metabolism; oxidative stress; inflammation; metabolic diseases; cardiometabolic health; plant-derived molecules

(This special issue belongs to the Section Nutrition and Metabolism)

Neuronutrition: Metabolomic Insights and Perspectives

edited by

Abraham Wall Medrano

and Rocío Campos Vega

submission deadline 30 Apr 2026 | 2 articles | Viewed by 5444 | Submission Open

Keywords: neuronutrition; neurological disorders; nutrition; functional foods; nutraceutical; nutrition physiology; nutriomics

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Profiling in Neurometabolisms

edited by Larissa Daniele Bobermin

submission deadline 30 Apr 2026 | 3 articles | Viewed by 4155 | Submission Open

Keywords: brain; energy homeostasis; glial cells; metabolic disorders; metabolic profiles; neurometabolism; neurons

Metabolomics Techniques in Nutrition and Pharmacy Research

edited by

Blake Rushing

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3978 | Submission Open

Keywords: metabolomics; precision nutrition; precision medicine; nutritional biomarkers; pharmacometabolomics; mass spectrometry; metabolic pathways; omics integration; diet– drug interactions; personalized therapeutics

(This special issue belongs to the Section Nutrition and Metabolism)

The Role of Diet and Nutrition in Relation to Metabolic Health

edited by

Ivana Šarac

Marija Paunovic

and

Marija Takić

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3356 | Submission Open

Keywords: dietary patterns; nutrients; metabolic syndrome; diet; metabolic health; nutritional biochemistry; dietotherapy; functional food; nutraceuticals

(This special issue belongs to the Section Nutrition and Metabolism)

Mass Spectrometry-Based Metabolomics for Advancing Personalized Medicine

edited by

Cristina Adela Iuga

and

Radu-Cristian Moldovan

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2534 | Submission Open

Keywords: mass spectrometry-based metabolomics; integrated-omics; personalized medicine; biomarker discovery

(This special issue belongs to the Section Advances in Metabolomics)

The Metabolic Genesis of Cardiovascular Disease

edited by

Davide Agnoletti

submission deadline 30 Apr 2026 | 1 articles | Viewed by 978 | Submission Open

Keywords: metabolic disorder; insulin resistance; inflammation; immune system; cardiovascular disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Impact of Toxic Metals on Human Metabolism and Health

edited by

Lucyna Kozlowska

submission deadline 30 Apr 2026 | 1 articles | Viewed by 908 | Submission Open

Keywords: metabolomics; exposomics; suspect screening; non-targeted screening; metals; health effect; metabolic profile

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Signature of Type 2 Diabetes, Insulin Resistance, and Obesity Triad

edited by Simona Georgiana Popa

submission deadline 30 Apr 2026 | 1 articles | Viewed by 857 | Submission Open

Keywords: cardiometabolic phenotypes of obesity; metabolomic profiles; microbiota; entero-insular axis; adipocytokines; precision therapy; insulin resistance; type 2 diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Research in Dairy Cattle Health

edited by

Wei Yang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 733 | Submission Open

Keywords: dairy cow; nutrient metabolism; feed ingredients; additives; disease; microbes; metabolite biomarkers

(This special issue belongs to the Section Animal Metabolism)

Diversity of Fungal Secondary Metabolites and Bioactive Compound Discovery

edited by

Fenglin Hu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 703 | Submission Open

Keywords: fungi; secondary metabolites; biosynthesis; analysis; bioactivity; identification; metabolism; utilization

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Metabolism and Reproduction in Animals

edited by

Simona Tafuri

and

Francesca Ciani

submission deadline 30 Apr 2026 | Viewed by 423 | Submission Open

Keywords: metabolism; reproduction; welfare; nutraceuticals; oxidative stress; antioxidants; inflammation; cancer

(This special issue belongs to the Section Animal Metabolism)

New Technology and Workflows for Advancing Metabolomics

edited by Lee Andrew Gethings

submission deadline 30 Apr 2026 | Viewed by 409 | Submission Open

Keywords: mass spectrometry; NMR; discovery metabolomics; targeted metabolomics; lipidomics; mass spectrometry imaging; new technology

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolomics of the Eye and Adnexa—2nd Edition

edited by

Seher Yuksel

and

Igor Butovich

submission deadline 30 Apr 2026 | Viewed by 398 | Submission Open

Keywords: metabolomics; metabolites; ocular disease; meibomian gland dysfunction; age-related macular degeneration; glaucoma; diabetic retinopathy; keratoconus; gas chromatography/liquid chromatography– mass spectrometry; nuclear magnetic resonance spectroscopy

(This special issue belongs to the Section Advances in Metabolomics)

Nature’s Vanguard: Secondary Metabolites and Their Emerging Role in the Evolution of Cancer Therapy

edited by

Thiago André Moura Veiga

and

Edgar Julian Paredes-Gamero

submission deadline 30 Apr 2026 | Viewed by 324 | Submission Open

Keywords: natural compounds; cell signaling; cytotoxic effects; mechanism of action; molecular dereplication; plant; fungi; bacteria; marines; molecular docking

(This special issue belongs to the Section Plant Metabolism)

Translational Perspectives on Cancer Energy Metabolism: From Metabolic Mechanisms to Clinical Applications

edited by

Michael Weichhaus

and Helen Turner

submission deadline 30 Apr 2026 | Viewed by 290 | Submission Open

Keywords: cancer metabolism; Warburg effect; metabolic reprogramming; metabolic flux analysis; biomarkers; targeted therapies; clinical translation; population metabolomics; health disparities

(This special issue belongs to the Section Cell Metabolism)

Salivary Biomarkers and Metabolites in Pigs

edited by

Fernando Tecles

submission deadline 30 Apr 2026 | Viewed by 285 | Submission Open

Keywords: saliva; biomarkers; welfare and health; animals

(This special issue belongs to the Section Animal Metabolism)

The Role of VOCs in Communication Between Plants and Microorganisms on Metabolomics

edited by

Valentina Lazazzara

submission deadline 30 Apr 2026 | Viewed by 256 | Submission Open

Keywords: volatile organic compounds (VOCs); plant-microbe interaction; sustainable agriculture; plant signaling; plant– pathogen interactions; plant growth promotion; microbial volatiles; plant defense mechanisms; biocontrol

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

The Aging Blueprint: Decoding Biomarkers of Bone and Muscle Health

edited by

Sagar Vyavahare

submission deadline 30 Apr 2026 | Viewed by 251 | Submission Open

Keywords: metabolomics; bone; muscle; aging; biomarker

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Drug Metabolism and New Drug Development for Cancers—2nd Edition

edited by

Anna Jelińska

and

Szymon Tomczak

submission deadline 30 Apr 2026 | Viewed by 240 | Submission Open

Keywords: cancer; new drug development; metabolites; secondary plant metabolites; drug delivery; nanoformulation; anticancer treatment

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Multi-Omics for Identifying Biosynthetic Pathways of Active Components in Medicinal Plants

edited by

Lihang Xie

and

Wolfgang Eisenreich

submission deadline 30 Apr 2026 | Viewed by 232 | Submission Open

Keywords: multi-omics; medicinal plants; bioactive natural products; biosynthetic pathway; metabolic engineering; microbial cell factories

(This special issue belongs to the Section Plant Metabolism)

Harnessing Cancer Metabolism: Unveiling New Therapeutic Approaches and Diagnostic Tools

edited by

Victor H. Villar

, Alejandro Huerta-Uribe and Ruhi Deshmukh

submission deadline 30 Apr 2026 | Viewed by 226 | Submission Open

Keywords: cancer; metabolic pathways; apoptosis; treatment

(This special issue belongs to the Section Cell Metabolism)

Metabolic and Neurodegenerative Disease Comorbidities

edited by

Aleksandra Szopa

and

Anna Serefko

submission deadline 30 Apr 2026 | Viewed by 213 | Submission Open

Keywords: metabolic disorders; neurodegeneration; diabetes; Alzheimer’ s disease; Parkinson’ s disease; mito-chondrial dysfunction; oxidative stress; neuroinflammation; gut– brain axis; metabolic comorbidities

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bile Acid Transport and Metabolic Disorders

edited by

Subha Arthur

submission deadline 30 Apr 2026 | Viewed by 208 | Submission Open

Keywords: bile acid transporters; FXR (Farnesoid X Receptor); TGR5; enterohepatic circulation; metabolic regulation; NAFLD (non-alcoholic fatty liver disease); gut microbiota; insulin resistance; bile acids and cardiovascular diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Dysfunction-Associated Steatotic Liver Disease: From Pathophysiology to Prevention Strategies

edited by

Seong-Uk Baek

and

Caroline Rhéaume

submission deadline 30 Apr 2026 | Viewed by 193 | Submission Open

Keywords: steatotic liver disease; epidemiology; MASLD; MAFLD; non-alcoholic fatty liver disease (NAFLD); liver metabolism; liver diseases; hepatic steatosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Computational Modeling of Metabolite-Modulated Cellular Processes

edited by

Md. Altaf-Ul-Amin

and Naoaki Ono

submission deadline 30 Apr 2026 | Viewed by 176 | Submission Open

Keywords: computational metabolomics; metabolic networks; metabolite-regulated cellular processes; natural products; drug discovery; metabolite biomarkers; machine learning algorithms

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Molecular Mechanisms of Metabolic Pathway Regulation by Phytochemicals

edited by

Carlos Lopez-Ortiz

submission deadline 4 May 2026 | Viewed by 254 | Submission Open

Keywords: phytochemicals; plant metabolism; secondary metabolites; gene expression regulation; metabolomics

(This special issue belongs to the Section Plant Metabolism)

Advances in NMR- and MS-Based Metabolomics and Its Applications

edited by

Anna Maria D’Ursi

and Carmen Marino

submission deadline 5 May 2026 | 3 articles | Viewed by 2638 | Submission Open

Keywords: NMR; MS; biofluids; machine learning; tissue; cells cultures; nutraceuticals

(This special issue belongs to the Section Advances in Metabolomics)

Open-Source Software in Metabolomics, 2nd Edition

edited by

Seongho Kim

submission deadline 10 May 2026 | Viewed by 209 | Submission Open

Keywords: GC- MS; LC-MS; mass spectrometry; metabolomics; open-source software

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease

edited by

Serena Castelli

and

Laura Mosca

submission deadline 15 May 2026 | 3 articles | Viewed by 4224 | Submission Open

Keywords: oxidative stress; metabolism; cellular signaling; lipid metabolism; ROS

(This special issue belongs to the Section Lipid Metabolism)

The Future Perspective on Screening and Diagnosis of Inborn Errors of Metabolism

edited by Luiz Carlos Santana-Da-Silva, Olga Yaneth Echeverri-Peña and

Angela J. Espejo-Mojica

submission deadline 15 May 2026 | 1 articles | Viewed by 885 | Submission Open

Keywords: inborn errors of metabolism (IEM); genetic disorders; diagnostics; biomarkers; omics sciences; imaging techniques (MRS; PET); molecular techniques (NGS; gene editing); personalized medi-cine; early detection

Immunometabolic Consequences of Aquatic Stress

edited by

Yanchun Sun

submission deadline 15 May 2026 | Viewed by 178 | Submission Open

Keywords: aquatic stress; metabolomics; immunometabolism; environmental immunology

(This special issue belongs to the Section Environmental Metabolomics)

Metabolomics of Human Nutrition: The Dot of Human Nutrition and the Circle of Soil, Plants, Animals and Microbes in Relation to It, 2nd Edition

edited by

Shoma Berkemeyer

submission deadline 21 May 2026 | 3 articles | Viewed by 5804 | Submission Open

Keywords: human nutrition; metabolomics; physiology; biochemistry; dietetics; pathophysiology; soil science; crop science; animal husbandry; microbes

(This special issue belongs to the Section Nutrition and Metabolism)

Targeted and Non-Targeted LC- and GC-HRMS Workflows for the Analysis of Emerging Contaminants and the Environmental Exposome

edited by Lapo Renai and

Massimo Del Bubba

submission deadline 21 May 2026 | 2 articles | Viewed by 3188 | Submission Open

Keywords: chromatography; high-resolution mass spectrometry; non-targeted analysis; exposome; data analysis; environmental analysis; pharmaceuticals; poly- and perfluorinated substances; personal care products; transformation products feature detection and identification

(This special issue belongs to the Section Environmental Metabolomics)

Phenological Regulation of Secondary Metabolism

edited by

Iván De-la-Cruz-Chacón

, Alma Rosa González-Esquinca and

Xin Fang

submission deadline 21 May 2026 | 1 articles | Viewed by 1371 | Submission Open

Keywords: phenological fluctuations; metabolites’ phenological fluctuations; secondary metabolites; natural products; specialized metabolites

(This special issue belongs to the Section Plant Metabolism)

Bioactive Metabolites from Fungal Endophytes Associated with Plants

edited by

Zhong-Hua Tang

and Chun-Hao Chang

submission deadline 22 May 2026 | 1 articles | Viewed by 1385 | Submission Open

Keywords: plants; fungal endophytes; bioactive metabolites; symbiotic interaction; biosynthetic gene clusters; plant– microbe co-evolution; natural product discovery; metabolomics; synthetic biology; antimicrobial activity

(This special issue belongs to the Section Plant Metabolism)

Bioactive Compounds: Plant Stress Responses, Metabolic Regulation, and Therapeutic Insights

edited by

Periyasamy Rathinapriya

and

Theivanayagam Maharajan

submission deadline 25 May 2026 | Viewed by 327 | Submission Open

Keywords: abiotic stress adaptation; antioxidant potential; cytotoxic and therapeutic activity; plant-derived elicitors; plant metabolism

(This special issue belongs to the Section Plant Metabolism)

Bioactive Secondary Metabolites from Marine Macro- and Microorganisms

edited by

Xiaowei Luo

and

Yonghong Liu

submission deadline 29 May 2026 | 1 articles | Viewed by 1155 | Submission Open

Keywords: secondary metabolites; bioactivity; marine natural products; marine microorganisms; marine organisms; drug discovery; lead compounds; pharmacological mechanism; marine drugs

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Research on Biomarkers for Cardiometabolic Risk in Metabolic Syndrome—2nd Edition

edited by Antoaneta Trifonova Gateva and Yavor Sashov Assyov

submission deadline 29 May 2026 | 1 articles | Viewed by 866 | Submission Open

Keywords: metabolic syndrome; vascular complications; biomarkers; carbohydrate disturbances; diabetes; pre-diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

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