Trauma and Emergency: Beyond Damage Control Surgery: 2nd Edition

Dear Colleagues,

Following the success of the first volume of our Special Issue “Trauma and Emergency: Beyond Damage Control Surgery”, we now invite high-quality submissions for volume II in the Medical Research Section. The first volume is available at https://www.mdpi.com/journal/life/special_issues/Trauma_Emergency_Surgery.

Contemporary studies on the management of severe injuries clearly indicate that patient outcomes correlate with the timeliness and appropriateness of their diagnosis and treatment. Effective management can halt the "hemorrhage-coagulopathy vicious cycle". However, the severity of the injury remains the foremost factor in determining the success of management. The "Danger model", a paradigm outlined in 2002 by Matzinger, proposes that the activation of the immune system is primarily attributed to products of damage and alarm signals emanating from injured tissues.

The varying severity of sterile post-injury inflammation and consequent organ dysfunction appears to relate to the level of immune reaction, which is consistent with the initial tissue damage caused by the trauma. A detailed understanding of these pathomechanisms could be valuable in predicting outcomes and identifying the most effective therapeutic approaches for serious trauma.

We look forward to examining recent discoveries in the area, with a specific focus on pathophysiological knowledge, diagnostic and prognostic approaches, and therapeutic strategies.

Dr. Giuseppe Ietto
Dr. Caterina Franchi
Dr. Matteo Zanchetta
Guest Editors

Manuscript Submission Information

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