Clinical Advances in Arrhythmology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 456

Special Issue Editor


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Guest Editor
Cardiology Unit, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, Italy
Interests: cardiology; arrhythmology; electrophysiology; cardiac pacing; defibrillation; atherosclerosis; myocardial infarction; acute myocardial infarction; chronic heart failure; echocardiography; coronary artery disease; heart failure; cardiovascular; pacemakers

Special Issue Information

Dear Colleagues,

In the last few years, Arrhythmology has made amazing progress.

New technologies such as left bundle branch area pacing or zero-fluoroscopy device implantations are revolutionizing Cardiac Stimulation, probably for the first time in over several decades.

Imaging techniques are fundamental not only as a guide to implantation, but also to evaluate cardiac performance with myocardial work analysis and other new indexes.

On the other hand, Electrophysiology has seen the establishment of three-dimensional electro-anatomical mapping systems, with new systems, now also combined with intracardiac echocardiography. Furthermore, new forms of energy delivery for transcatheter ablation, such as electroporation, are emerging and being used together with traditional ones such as radiofrequency and cryoablation.

The availability of modern interventive techniques and tools in recent years prompted a rapid evolution of those themes.

In addition to technological advancements, there has been a growing emphasis in Arrhythmology on personalized medicine with new treatment options becoming available to clinicians and tailoring treatment plans based on the unique genetic profile of patients. Specific populations (i.e., genetic conduction disorders, congenital heart diseases, hemoglobinopathies, inherited channelopathies and many others) have probably been previously under-considered but are not comparable to the general population and deserve specific evidence.

It is with great enthusiasm that we follow these advances.

We hope that our Special Issue can contribute to spreading the great progresses of Arrhythmology.

Dr. Michele Malagù
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • arrhythmia
  • pacing
  • electrophysiology
  • mapping
  • ablation
  • implant
  • atrial fibrillation
  • conduction
  • block
  • devices
  • mapping system
  • heart failure
  • cardiac imaging
  • echocardiog-raphy
  • magnetic resonance imaging
  • computed tomography

Published Papers (1 paper)

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Research

9 pages, 763 KiB  
Article
Association between Epicardial Adipose Tissue and Atrial Fibrillation in Patients with Transfusion-Dependent β-Thalassemia
by Michele Malagù, Elisabetta Tonet, Giovanni Orazio, Filomena Longo, Martina De Raffele, Paolo Sirugo, Andrea Capanni, Stefano Clò, Maria Letizia Berloni, Federico Marchini, Marco Manfrini, Elisa Mari, Olga Soffritti, Martina Culcasi, Cristina Balla, Francesco Vitali, Alberto Cossu and Matteo Bertini
J. Clin. Med. 2024, 13(12), 3471; https://doi.org/10.3390/jcm13123471 - 14 Jun 2024
Viewed by 183
Abstract
Background: Modern treatments for transfusion-dependent β-thalassemia (TDβT) have allowed patients to reach high life expectancy with no iron overload. Despite survival improvement, atrial fibrillation (AF) has emerged as a relevant issue. AF pathophysiology and characteristics in TDβT are different than in the general [...] Read more.
Background: Modern treatments for transfusion-dependent β-thalassemia (TDβT) have allowed patients to reach high life expectancy with no iron overload. Despite survival improvement, atrial fibrillation (AF) has emerged as a relevant issue. AF pathophysiology and characteristics in TDβT are different than in the general population. Epicardial adipose tissue (EAT) may play a role but its relationship with AF in patients with TDβT has not been explored. Methods: A monocentric, cross-sectional study, enrolling consecutive patients with TDβT. Epicardial adipose tissue (EAT) was evaluated at magnetic resonance. Characteristics of patients with and without history of AF were investigated. Factors independently associated with AF prevalence were analyzed. Results: A total of 116 patients were enrolled. All patients were treated with regular chelation therapy. The prevalence of AF was 29.3% (34/116). Cardiac T2* and liver iron concentration were no different between patients with and without AF. EAT thickness was significantly higher in patients with AF at left atrium, right atrium and right ventricle (5.0 vs. 4.0 mm, p < 0.01, 4.4 vs. 4.0, p = 0.02 and 5.0 vs. 4.3, p = 0.04). Patients with AF presented with older age, (53 vs. 49 years, p < 0.01), more hypothyroidism (44.1 vs. 20.7%, p = 0.01), pulmonary hypertension (23.5 vs. 2.4% p < 0.01), splenectomy (88.2 vs. 64.6%, p = 0.01), higher right and left atrial volume (61 vs. 40 and 74 vs. 43 mL, both p < 0.01). At multivariable analysis, hypothyroidism, left atrial volume and left atrial EAT were independently associated with AF (odds ratio 9.95, 1.09 and 1.91, respectively). Conclusions: In a contemporary cohort of patients with TDβT, treated with regular chelation therapy, prevalence of AF was unrelated to iron overload. EAT was independently associated with AF. Full article
(This article belongs to the Special Issue Clinical Advances in Arrhythmology)
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