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Nanotechnology in the Treatment and Diagnosis of Cancer: Opportunities and Challenges

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 May 2024) | Viewed by 547

Special Issue Editor


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Guest Editor
1. Department of Molecular Biology and Translational Research, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
2. World Institute for Family Health, University of Kalisz, Nowy Swiat 4, 62-800 Kalisz, Poland
Interests: nanotoxicology; impact of nanoparticles on cancer; pesticides toxicity; environmental health

Special Issue Information

Dear Colleagues,

According to the latest available data prepared by the World Health Organization, cancer caused almost 10 million deaths in 2020, and at the same time almost 20 million new cases were identified. However, many cancers can be cured if detected and treated early enough. Advances in nanotechnology over recent decades have provided new hope in cancer treatment. Nanomaterials are successfully used at the diagnostic stage, supporting various imaging techniques. Additionally, a number of nanocarriers have been developed for the transport of cytostatic drugs. Moreover, nanotechnology has been used in many forms of anticancer therapy. The use of nanomaterials per se as active substances with direct anticancer effects is also widely discussed.

However, the number of nanomedicines approved for use has not increased significantly over the years. Scientists encounter numerous challenges when trying to transfer the results of in vitro/in vivo research to clinical conditions. There is also an increasing discussion on the scientific forum about the broad spectrum of toxicity of nanomaterials, including their potential procarcinogenic and prometastatic effects.

The aim of this Special Issue is to create a space in which you will be able to share with a wide audience the results of research relating primarily to the use of nanotechnology in the diagnosis and treatment of cancer, but also focusing on the assessment of the safety of used nanomaterials.

This Special Issue is supervised by Prof. Dr. Lucyna Kapka-Skrzypczak and assisted by our Topical Advisory Panel Member, Dr. Magdalena Matysiak-Kucharek (Institute of Rural Health).

Prof. Dr. Lucyna Kapka-Skrzypczak
Guest Editor

Manuscript Submission Information

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Keywords

  • nanomaterials
  • cancer
  • nanomedicine
  • biological effects
  • cancer therapy
  • metastasis

Published Papers (1 paper)

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Research

23 pages, 6631 KiB  
Article
The Synergistic Effect of Reduced Graphene Oxide and Proteasome Inhibitor in the Induction of Apoptosis through Oxidative Stress in Breast Cancer Cell Lines
by Rafał Krętowski, Beata Szynaka, Agata Jabłońska-Trypuć, Anna Kiełtyka-Dadasiewicz and Marzanna Cechowska-Pasko
Int. J. Mol. Sci. 2024, 25(10), 5436; https://doi.org/10.3390/ijms25105436 - 16 May 2024
Viewed by 365
Abstract
Reduced graphene oxide (rGO) and a proteasome inhibitor (MG-132) are some of the most commonly used compounds in various biomedical applications. However, the mechanisms of rGO- and MG-132-induced cytotoxicity remain unclear. The aim of this study was to investigate the anticancer effect of [...] Read more.
Reduced graphene oxide (rGO) and a proteasome inhibitor (MG-132) are some of the most commonly used compounds in various biomedical applications. However, the mechanisms of rGO- and MG-132-induced cytotoxicity remain unclear. The aim of this study was to investigate the anticancer effect of rGO and MG-132 against ZR-75-1 and MDA-MB-231 breast cancer cell lines. The results demonstrated that rGO, MG-132 or a mix (rGO + MG-132) induced time- and dose-dependent cytotoxicity in ZR-75-1 and MDA-MB-231 cells. Apart from that, we found that treatment with rGO and MG-132 or the mix increased apoptosis, necrosis and induction of caspase-8 and caspase-9 activity in both breast cancer cell lines. Apoptosis and caspase activation were accompanied by changes in the ultrastructure of mitochondria in ZR-75-1 and MDA-MB-231 cells incubated with rGO. Additionally, in the analyzed cells, we observed the induction of oxidative stress, accompanied by increased apoptosis and cell necrosis. In conclusion, oxidative stress induces apoptosis in the tested cells. At the same time, both mitochondrial and receptor apoptosis pathways are activated. These studies provided new information on the molecular mechanisms of apoptosis in the ZR-75-1 and MDA-MB-231 breast cancer cell lines. Full article
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