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Dentistry Journal
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Advances in Periodontal and Peri-Implant Tissues Health Management
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Advances in Periodontal and Peri-Implant Tissues Health Management

A special issue of Dentistry Journal (ISSN 2304-6767). This special issue belongs to the section "Oral Hygiene, Periodontology and Peri-implant Diseases".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 11725

Special Issue Editors

Dr. Federica Di Spirito

E-Mail Website
Guest Editor
Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Baronissi, Italy
Interests: oral medicine and interconnected systemic disorders; oral microbiome, dysbiosis and interconnected systemic disorders; periodontology and implantology; applied technologies (disease prevention, teledentistry, machine learning in dentistry education)
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandra Amato

E-Mail Website
Guest Editor
Department of Neuroscience, Reproductive Science and Dentistry, University of Naples Federico II, 80131 Naples, Italy
Interests: general dentistry; translational medicine; orthodontics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a pleasure to invite you to submit manuscripts to the forthcoming Special Issue “Advances in Periodontal and Peri-implant Tissues Health Management” that will be published in Dentistry Journal.

Periodontal and peri-implant diseases constitute an important public health problem, most often under-acknowledged and implicated with general health, oral health-related quality of life and socioeconomic burden, thus enhancing the prevention of periodontitis and peri-implantitis onset and progression should be considered crucial. Moreover, due to the interconnections between periodontal, peri-implant and general health status, principally relying on inflammatory response, periodontal immune-microbiome balance and neurobiological and genetic factors, subjects considered high risk for periodontitis and peri-implantitis development, as well as periodontal patients more prone to the onset or worsening of systemic disorders, should be regarded with caution in multi-disciplinary settings, improving interprofessional communication and collaboration.

Original studies, from basic to clinical research, as well as reviews, case series, case reports and short communications, that provide deeper insights into the etiopathogenesis, the putative interconnections with systemic diseases and neoplasms of such complex disorders and the possible mechanisms underlying aggressive, recurrent and refractory cases, potentially paving the way for innovative primary prevention strategies and therapeutic approaches in regards to more comprehensive and integrated management of periodontal and peri-implant diseases, with high-quality precision on a large scale and with personalized periodontal care for high-risk subjects, will be welcome.

Dr. Federica Di Spirito
Dr. Alessandra Amato 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontal health
  • periodontal tissues
  • periodontal disease
  • gingivitis
  • periodontitis
  • peri-implant health
  • peri-implant tissues
  • peri-implant disease
  • peri-implantitis
  • peri-implant mucositis
  • periodontal treatment
  • periodontal care
  • periodontitis management
  • periodontitis management
  • periodontitis prevention
  • peri-implantitis prevention
  • microbiome
  • periodontal manifestations of systemic disease
  • tissue regeneration
  • bone regeneration
  • interdisciplinary approach

Published Papers (6 papers)

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Research

Jump to: Review, Other

18 pages, 1457 KiB  
Article
A Low-Cost Protocol Using the Adjunctive Action of Povidone–Iodine Irrigations and Sodium Hypochlorite Rinsing Solution in Step 2 of Periodontal Therapy for Patients with Stage III–IV Periodontitis: A Single-Blind, Randomized Controlled Trial
by Georgios Kardaras, Ruxandra Christodorescu, Marius Boariu, Darian Rusu, Alla Belova, Salvatore Chinnici, Octavia Vela, Viorelia Radulescu, Simina Boia and Stefan-Ioan Stratul
Dent. J. 2024, 12(5), 144; https://doi.org/10.3390/dj12050144 - 15 May 2024
Viewed by 571
Abstract
In severe stages of periodontitis, conventional periodontal therapy and maintenance care are usually insufficient due to the viral and bacterial etiology; thus, a mechanical approach alone may not be sufficient to eliminate a substantial portion of subgingival pathogens, especially in deep periodontal sites. [...] Read more.
In severe stages of periodontitis, conventional periodontal therapy and maintenance care are usually insufficient due to the viral and bacterial etiology; thus, a mechanical approach alone may not be sufficient to eliminate a substantial portion of subgingival pathogens, especially in deep periodontal sites. Background and Objectives: This single-blind, randomized clinical trial aimed to compare the clinical and microbiological efficacy of a low-cost protocol using povidone–iodine and sodium hypochlorite formulations as adjuncts to non-surgical therapy for patients with stage IV periodontitis when compared with chlorhexidine, the most commonly employed substance to date for antimicrobial regimens in periodontal therapy. Materials and Methods: Forty-five patients were randomly divided into two groups: control (subgingival instrumentation, chlorhexidine-assisted) and test (antiviral medication, subgingival instrumentation with povidone–iodine, sodium hypochlorite rinsing solution, and antibiotics). Clinical measurements and microbiological analyses were performed at baseline and after three months. Results: After three months, notable differences were found in the bacterial detection scores for Porphyromonas gingivalis (a significant reduction in detection frequency was observed in the test compared to the control (p = 0.021)), and there were significant reductions in detection in the test group for Tannerella forsythia and Treponema denticola, showing undetectable levels (p < 0.0001 for both). In the test group, the pocket probing depth median value was reduced significantly (p = 0.0005); similarly, bleeding on probing showed a marked decrease (p < 0.0001). However, changes in clinical attachment loss and full-mouth plaque score were not statistically significant. Conclusions: Using the proposed protocol, substantial improvements in clinical and microbiological parameters were obtained when compared with the current antimicrobial recommendations. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management)
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10 pages, 1516 KiB  
Article
The Use of Enamel Matrix Derivative during Surgical Therapy for Peri-Implantitis: A Case Series
by Thomas G. Wilson, Jr., Stephen K. Harrel and Martha E. Nunn
Dent. J. 2024, 12(1), 11; https://doi.org/10.3390/dj12010011 - 30 Dec 2023
Viewed by 1502
Abstract
Peri-implantitis is a growing concern and currently, there is no agreement on the best method for treating this condition. This study looked at surgical intervention with the use of enamel matrix derivative (EMD) for treating this condition. A cohort of 25 (34 implants) [...] Read more.
Peri-implantitis is a growing concern and currently, there is no agreement on the best method for treating this condition. This study looked at surgical intervention with the use of enamel matrix derivative (EMD) for treating this condition. A cohort of 25 (34 implants) consecutive patients treated with EMD for peri-implantitis was followed for up to 6.4 years. The survival of the implants as well as changes in clinical parameters are reported. Statistical analysis was performed using paired t tests and general estimating equations. The mean length of time implants were followed post-surgery was 3.05 ± 1.53 years. All but two of the treated implants survived in function (94%). Both failed implants were lost in the same patient, who was a heavy smoker. The changes in mean probing depth (1.94 ± 1.18 mm), change in deepest probing depth (3.12 ± 1.45 mm), and reduction in bleeding on probing (73.6 ± 43.9%) according to patient means were all highly significant (p < 0.001 for all changes). When EMD is used during surgical treatment of peri-implantitis, there is a high survival rate of implants and significant improvements in clinical parameters. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management)
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13 pages, 3174 KiB  
Article
A New Way to Model Periodontitis in Laboratory Animals
by Denis Moiseev, Sergey Donskov, Ivan Dubrovin, Mariya Kulyukina, Yuriy Vasil’ev, Beatrice Volel, Shodiya Shadieva, Aleksey Babaev, Juliya Shevelyuk, Anatolij Utyuzh, Ellina Velichko, Sergey Dydykin, Irina Dydykina, Yuri Paramonov and Ekaterina Faustova
Dent. J. 2023, 11(9), 219; https://doi.org/10.3390/dj11090219 - 18 Sep 2023
Cited by 1 | Viewed by 1690
Abstract
The prevalence of periodontal diseases is increasing, tends to increase with age and is considered as one of the main causes of tooth loss. To assess the effectiveness of new methods of treatment of periodontal diseases, studies on laboratory animals can be promising. [...] Read more.
The prevalence of periodontal diseases is increasing, tends to increase with age and is considered as one of the main causes of tooth loss. To assess the effectiveness of new methods of treatment of periodontal diseases, studies on laboratory animals can be promising. The aim of the study: to develop a new method of accelerated modeling of experimental periodontitis on laboratory animals. Material and methods. The study was carried out on 22 female rats. A wire ligature was applied to the cervical area of the incisors of the animals in an eight-shaped manner. Plaque obtained from a patient with periodontitis was placed under the wire, and nicotine and ethyl alcohol solutions were injected under the gingival mucosa. A complex index has been proposed to assess inflammation. At the end of the experiment the animals were euthanized, their jaws were dissected into dentoalveolar blocks and further descriptive histologic analysis was performed. Results. On the second day the gingiva of the rats acquired a cyanotic-pink color, on the fourth day the consistency of the gingiva became friable, mobility appeared in the lower incisors. Complex index of inflammation in animals of the main group: before the study—9, on the 7th day—195. Gingival preparations showed signs of exudative inflammation. In alveolar processes—irreversible resorption of bone structures. The difference of indicators in animals before and after the experiment was statistically significant (p < 0.05). Conclusion. The new experimental model of periodontitis is reproduced in a short period of time, provides intensive development of inflammation, leads to disruption of the integrity of epithelial and connective tissue attachment, destruction of alveolar bone. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management)
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Review

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37 pages, 2472 KiB  
Review
Periodontal Management in Periodontally Healthy Orthodontic Patients with Fixed Appliances: An Umbrella Review of Self-Care Instructions and Evidence-Based Recommendations
by Federica Di Spirito, Alessandra Amato, Maria Pia Di Palo, Davide Cannatà, Francesco Giordano, Francesco D’Ambrosio and Stefano Martina
Dent. J. 2023, 11(2), 35; https://doi.org/10.3390/dj11020035 - 31 Jan 2023
Cited by 13 | Viewed by 2235
Abstract
The present umbrella review aimed to characterize periodontal self-care instructions, prescriptions, and motivational methods; evaluate the associated periodontal outcomes; and provide integrated, evidence-based recommendations for periodontal self-care in periodontally healthy orthodontic patients with fixed appliances. The presently applied study protocol was developed in [...] Read more.
The present umbrella review aimed to characterize periodontal self-care instructions, prescriptions, and motivational methods; evaluate the associated periodontal outcomes; and provide integrated, evidence-based recommendations for periodontal self-care in periodontally healthy orthodontic patients with fixed appliances. The presently applied study protocol was developed in advance, compliant with the PRISMA statement, and registered on PROSPERO (CRD42022367204). Systematic reviews published in English without date restrictions were electronically searched until 21 November 2022 across the PROSPERO Register and Cochrane Library, Web of Science (Core Collection), Scopus, and MED-LINE/PubMed databases. The study quality assessment was conducted through the AMSTAR 2 tool. Seventeen systematic reviews were included. Powered and manual toothbrushes showed no significant differences in biofilm accumulation, although some evidence revealed significant improvements in inflammatory, bleeding, and periodontal pocket depth values in the short term with powered toothbrushes. Chlorhexidine mouthwashes, but no gels, varnishes, or pastes, controlled better biofilm accumulation and gingival inflammation as adjuncts to toothbrushing, although only for a limited period. Organic products, such as aloe vera and chamomile, proved their antimicrobial properties, and herbal-based mouthwashes seemed comparable to CHX without its side effects. Motivational methods also showed beneficial effects on periodontal biofilm control and inflammation, while no evidence supported probiotics administration. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management)
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Other

Jump to: Research, Review

22 pages, 5774 KiB  
Systematic Review
The Use of Statins as an Adjunctive Periodontal Disease Treatment: Systematic Review and Meta-Analysis
by Alice Rose Greethurst, Cosimo Galletti, Roberto Lo Giudice, José Nart, Cristina Vallés, Francisco Real-Voltas, Cosme Gay-Escoda and Enrico Marchetti
Dent. J. 2024, 12(6), 150; https://doi.org/10.3390/dj12060150 - 21 May 2024
Viewed by 345
Abstract
Background: the purpose of this systematic review was to assess the clinical and radiographic effect of subgingival-administered statins as an adjunct periodontal treatment in patients with periodontitis. Methods: Electronic literature searches in Medline/PubMed and the Cochrane Library were conducted to identify all relevant [...] Read more.
Background: the purpose of this systematic review was to assess the clinical and radiographic effect of subgingival-administered statins as an adjunct periodontal treatment in patients with periodontitis. Methods: Electronic literature searches in Medline/PubMed and the Cochrane Library were conducted to identify all relevant articles. Eligibility was based on inclusion criteria which included Randomized Controlled Trials (RCTs) published after 2010, where the periodontal variables were assessed before and after periodontal treatment in combination with a statin administration. The risk of bias was assessed with the ROBINS-2 tool. The outcome variables were probing depth, clinical attachment level, bleeding on probing, and bone fill in systematically healthy patients, patients with type 2 diabetes, and smokers. Results: Out of 119 potentially eligible articles, 18 randomized controlled trials were included with a total of 1171 participants. The data retrieved from the meta-analysis showed the positive effect that statins have as an adjunctive periodontal disease treatment. When comparing the different types of statins, the PD reduction in the Simvastatin group was significantly higher than the Atorvastatin group at 6 months and at 9 months, while no differences between statins were found for the rest of the outcomes. Over 66% of the articles presented an overall risk of bias with some concerns, making this a limitation of this present RCT. Conclusions: The adjunct administration of statins has proven to have a positive effect on the periodontium by improving both clinical and radiographic parameters by a considerable margin. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management)
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18 pages, 516 KiB  
Systematic Review
Smoking Cessation on Periodontal and Peri-Implant Health Status: A Systematic Review
by Mario Caggiano, Roberta Gasparro, Francesco D’Ambrosio, Massimo Pisano, Maria Pia Di Palo and Maria Contaldo
Dent. J. 2022, 10(9), 162; https://doi.org/10.3390/dj10090162 - 31 Aug 2022
Cited by 16 | Viewed by 4237
Abstract
Since smoking is considered among the main risk factors for the onset and progression of periodontitis and peri-implantitis, the present systematic review aimed to evaluate the effect of smoking cessation on clinical, radiographic, and gingival crevicular periodontal parameters around natural teeth and dental [...] Read more.
Since smoking is considered among the main risk factors for the onset and progression of periodontitis and peri-implantitis, the present systematic review aimed to evaluate the effect of smoking cessation on clinical, radiographic, and gingival crevicular periodontal parameters around natural teeth and dental implants in ex-smokers compared to current and non-smokers. The study protocol was developed based on the PRISMA guidelines, the research question was formulated according to the PICO model, and the literature search was conducted through PubMed/MEDLINE, Cochrane library, and BioMed Central databases. From the 916 title/abstracts initially identified, seven articles were included in the present systematic review and assessed for quality through the ROBINS-I tool. Reported findings on clinical and crevicular periodontal parameters around natural teeth were contrasting when comparing ex-smokers to current and non-smokers; thus, individualized recommendations for previous smoker periodontal patients are currently lacking. No data on radiographic parameters were retrieved. Similarly, data on periodontal parameters around dental implants were not available, highlighting the need for focused investigations assessing the role of both smoking habit and cessation on peri-implant health status and responsiveness to treatment. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management)
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