Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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In Vitro Models for Assessing Toxicity and Cellular Effects
edited by , , and Camilla Paoletti
submission deadline 30 Jul 2026 | Viewed by 267 | Submission Open
Keywords: alternative testing; NAMs; 3D in vitro models; organ-on-chip; millifluidic cultures; toxicity; biomaterials; 3Rs; organoids
Cancer Cytopathology: Structural Features and Intracellular Events in Malignancy submission deadline 30 Jul 2026 | Viewed by 219 | Submission Open
Keywords: cancer cells; cytopathology; tumor microenvironment; cell culture; biopsies
(This special issue belongs to the Section Cellular Pathology)
Targeted Therapy and Immunotherapy in Breast Cancer: Molecular Mechanisms and Translational Advances
edited by Saranya Chumsri, Hatem H. Soliman and
submission deadline 30 Jul 2026 | Viewed by 218 | Submission Open
Keywords: breast cancer; targeted therapy; immunotherapy; biomarkers of response; therapeutic resistance
(This special issue belongs to the Section Cellular Immunology)
Cellular Mechanisms of Anti-Cancer Therapies
edited by Ilgen Mender and
submission deadline 31 Jul 2026 | 8 articles | Viewed by 30497 | Submission Open
Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine
(This special issue belongs to the Section Cellular Pathology)
How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies submission deadline 31 Jul 2026 | 6 articles | Viewed by 17264 | Submission Open
Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention
(This special issue belongs to the Section Cell Microenvironment)
Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases
edited by and Katie S. Wraith
submission deadline 31 Jul 2026 | 7 articles | Viewed by 11574 | Submission Open
Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular and Molecular Mechanisms of Vascular-Related Diseases
edited by and
submission deadline 31 Jul 2026 | 8 articles | Viewed by 11494 | Submission Open
Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system
(This special issue belongs to the Section Cellular Pathology)
Advances in the Discovery of Retinal Degeneration submission deadline 31 Jul 2026 | 6 articles | Viewed by 10739 | Submission Open
Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology
(This special issue belongs to the Section Cellular Pathology)
Mechanisms of Lung Growth and Regeneration submission deadline 31 Jul 2026 | 5 articles | Viewed by 9578 | Submission Open
Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq
(This special issue belongs to the Section Cell Microenvironment)
Adipose Tissue Functioning in Health and Diseases
edited by Richard C Chang
submission deadline 31 Jul 2026 | 5 articles | Viewed by 8136 | Submission Open
Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance
(This special issue belongs to the Section Tissues and Organs)
Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities
edited by
submission deadline 31 Jul 2026 | 3 articles | Viewed by 6584 | Submission Open
Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders
edited by Irina Balan
submission deadline 31 Jul 2026 | 4 articles | Viewed by 6208 | Submission Open
Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors
(This special issue belongs to the Section Cellular Pathology)
Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer submission deadline 31 Jul 2026 | 5 articles | Viewed by 5789 | Submission Open
Keywords: tumor microenvironment; epithelial– mesenchymal transition (EMT); tumor– stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology
Cellular and Molecular Mechanisms in Immune Regulation—Second Edition
edited by Fábio Rinaldo Santori and Natalia B. Ivanova
submission deadline 31 Jul 2026 | 6 articles | Viewed by 5186 | Submission Open
Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Heart Diseases
edited by
submission deadline 31 Jul 2026 | 2 articles | Viewed by 5047 | Submission Open
Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies
(This special issue belongs to the Section Cellular Pathology)
The Role of Pancreatic Beta-Cells in Obesity and Type 2 Diabetes
edited by Mayur Doke, Juan Domínguez-Bendala and Oscar Alcazar
submission deadline 31 Jul 2026 | 3 articles | Viewed by 4962 | Submission Open
Keywords: pancreatic beta-cells; GLP-1; obesity; type 2 diabetes; islet biology; beta-cell regeneration; insulin resistance; incretin therapies; single-cell transcriptomics; metabolic stress
Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation
edited by Hari Krishnareddy Rachamala and
submission deadline 31 Jul 2026 | 2 articles | Viewed by 4238 | Submission Open
Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology
(This special issue belongs to the Section Cell Methods)
Integrated Approaches Between Metabolomics and Cellular Aging
edited by Maria Nikolaou and
submission deadline 31 Jul 2026 | 2 articles | Viewed by 4110 | Submission Open
Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism
(This special issue belongs to the Section Cellular Aging)
Genetic Mechanisms in Cellular Genomics and Therapeutics
edited by Elaine T. Lim and Yingleong Chan
submission deadline 31 Jul 2026 | 1 articles | Viewed by 4075 | Submission Open
Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases
Epigenetic Mechanisms of Tumorigenesis
edited by
submission deadline 31 Jul 2026 | 2 articles | Viewed by 3599 | Submission Open
Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine
Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer
edited by and Marika Fava
submission deadline 31 Jul 2026 | 1 articles | Viewed by 3246 | Submission Open
Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards
Regulation of Ca2+ Signals in Human Disease
edited by Yandong Zhou
submission deadline 31 Jul 2026 | 3 articles | Viewed by 2906 | Submission Open
Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets
(This special issue belongs to the Section Cell Signaling)
Cellular and Molecular Mechanisms of Neurotoxicity
edited by , , Tiziana Cotrufo and
submission deadline 31 Jul 2026 | 2 articles | Viewed by 2590 | Submission Open
Keywords: neurotoxicity; neurodegeneration; neuronal cell death; neurodegenerative disorders; nerve regeneration; heavy metals; air pollution; endogenous neurotoxins; oxidative stress; glutamate
Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health
edited by
submission deadline 31 Jul 2026 | 2 articles | Viewed by 2307 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines
The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders
edited by , and Adriana C. E. Graziano
submission deadline 31 Jul 2026 | 2 articles | Viewed by 2250 | Submission Open
Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation
(This special issue belongs to the Section Cellular Neuroscience)
Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation submission deadline 31 Jul 2026 | 1 articles | Viewed by 1902 | Submission Open
Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics
(This special issue belongs to the Section Stem Cells)
The Role of Cell Signaling Pathway Starvation Therapy for Cancer
edited by and Min You
submission deadline 31 Jul 2026 | 2 articles | Viewed by 1788 | Submission Open
Keywords: signaling pathways; nutrient deprivation; starvation therapy; metabolic reprogramming; metabolic pathways
(This special issue belongs to the Section Cell Signaling)
Molecular Research in Osteoporosis submission deadline 31 Jul 2026 | 1 articles | Viewed by 1556 | Submission Open
Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy
(This special issue belongs to the Section Cellular Pathology)
Rho Family Small GTPases in Health and Diseases
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1282 | Submission Open
Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors  
(This special issue belongs to the Section Cell Signaling)
From Molecular Mechanisms to Treatment Progress of Ovarian Cancer
edited by Amal M. El-Naggar
submission deadline 31 Jul 2026 | 2 articles | Viewed by 1141 | Submission Open
Keywords: ovarian cancer; molecular mechanisms; therapeutic targets; drug resistance; biomarkers; preclinical models; targeted therapy; immunotherapy; tumor microenvironment; translational research
(This special issue belongs to the Section Reproductive Cells and Development)
Aquaporins at the Crossroads of Human Health and Disease
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 964 | Submission Open
Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics
Application of Stem Cells and Cellular Engineering in Musculoskeletal Tissue Regeneration submission deadline 31 Jul 2026 | 1 articles | Viewed by 828 | Submission Open
Keywords: mesenchymal stem cells (MSCs); tissue specific progenitors; cellular engineering; musculoskeletal tissue regeneration; tissue engineering; biomaterials; 3D culture systems; mechanobiology; extracellular vesicles; translational regenerative medicine
(This special issue belongs to the Section Stem Cells)
Advances in Toxoplasma gondii Treatment, Immunology and Host–Parasite Interaction
edited by Namrata Anand
submission deadline 31 Jul 2026 | 1 articles | Viewed by 749 | Submission Open
Keywords: T. gondii; treatment strategies; secretory proteins; immune response; exosomes; nanoparticle; congenital infection; host– parasite interaction
(This special issue belongs to the Section Cellular Immunology)
Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer—2nd Edition
edited by Sachin Mulik, Weshely Kujur, and Sumit Sen Santara
submission deadline 31 Jul 2026 | 1 articles | Viewed by 732 | Submission Open
Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes
(This special issue belongs to the Section Cellular Immunology)
Is Gene Therapy the Answer to Overcoming Diabetes? submission deadline 31 Jul 2026 | Viewed by 339 | Submission Open
Keywords: gene therapy; type 1 diabetes; type 2 diabetes; glycemic control; beta-cell transcription factors; insulin granules; viral vectors
Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism
edited by , Sandra Kostić and Anita Racetin
submission deadline 31 Jul 2026 | Viewed by 325 | Submission Open
Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration
Kinin System in Health and Disease: Cellular and Molecular Perspectives
edited by Marcos Gregnani and Leonardo Martins
submission deadline 31 Jul 2026 | Viewed by 305 | Submission Open
Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways
(This special issue belongs to the Section Cellular Pathology)
ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights submission deadline 31 Jul 2026 | Viewed by 276 | Submission Open
Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC; FISH; NGS); targeted therapy
Interactions Between Nanomaterials and Cells
edited by Ali Dinari and
submission deadline 31 Jul 2026 | Viewed by 267 | Submission Open
Keywords: nanomaterial– cell interactions; nanomedicine; cellular uptake and trafficking; nano– bio interface; intracellular signaling; cellular stress and toxicity; stem cells and nanomaterials; advanced imaging and characterization
(This special issue belongs to the Section Cellular Biophysics)
Recent Insights into the Role of Metal Ions in the Nervous System
edited by Richard H. Dyck
submission deadline 31 Jul 2026 | Viewed by 266 | Submission Open
Keywords: metal ions; neurobiology; zinc signalling; copper homeostasis; iron metabolism; calcium signalling; magnesium; lithium; metallomics; synaptic transmission; neuromodulation; ion transporters; metal-binding proteins; oxidateive stress; mitochondrial function; neurodevelopment; synaptic plasticity; neuroinflammation; neurodegeneration; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; Alzheimer disease; Parkinson disease; imaging of metal ions; metal ion dysregulation
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Signatures and Cellular Pathways of Immune Dysfunction in HIV and Tuberculosis
edited by , Pradeep Kumar Sheokand, , Ekta Saini and Prashant Bajpai
submission deadline 31 Jul 2026 | Viewed by 263 | Submission Open
Keywords: immune cell dysfunction; immune persistence; T cell exhaustion; chronic infection; host– pathogen interactions; cellular immunity; molecular immune signaling; single-cell immunology; immune cell plasticity; infection-induced immune remodeling
(This special issue belongs to the Section Cellular Immunology)
Advances in the Gut–Liver–Brain Axis in Human Health and Disease
edited by
submission deadline 31 Jul 2026 | Viewed by 251 | Submission Open
Keywords: gut– liver– brain axis; microbiota; liver metabolism; neuroinflammation; metabolic disease; neurodegeneration; gut– brain communication
Histological Classification of Lung Cells Across Animal Models and Life Stages
edited by
submission deadline 31 Jul 2026 | Viewed by 236 | Submission Open
Keywords: lung parenchyma; histological classification; normal lung anatomy; spatial organization; animal models; non-rodent models; comparative lung anatomy; lung ageing
(This special issue belongs to the Section Tissues and Organs)
Extracellular Vesicles: Drivers, Biomarkers and Therapeutics in Cardiovascular Disease submission deadline 31 Jul 2026 | Viewed by 221 | Submission Open
Keywords: cardiovascular disease; extracellular vesicles; biomarkers; therapeutics; drug delivery; RNA therapeutics; fibrosis; atherosclerosis; liquid biopsy
Sex Differences in Molecular Mechanisms Linking Physiological Stress and Inflammation
edited by John R. Bethea and Kayla Lee Nguyen
submission deadline 31 Jul 2026 | Viewed by 216 | Submission Open
Keywords: ER stress; intracellular signaling; neuronal stress; immune activation; sex differences; neuro-immune interactions
(This special issue belongs to the Section Cellular Neuroscience)
Tau-Targeted Treatment of Alzheimer’s Disease
edited by Amritpal Mudher, Katerina Papanikolopoulou, Lovesha Sivanantharajah and
submission deadline 31 Jul 2026 | Viewed by 215 | Submission Open
Keywords: tau protein; Alzheimer's disease; therapeutic targeting; tauopathy; neurodegeneration; disease models; drug discovery; protein aggregation
(This special issue belongs to the Section Cellular Neuroscience)
Molecular and Cellular Mechanisms of Pheochromocytoma and Paraganglioma
edited by and
submission deadline 31 Jul 2026 | Viewed by 214 | Submission Open
Keywords: pheochromocytoma; paraganglioma; tumor biology; molecular mechanisms; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Signaling Dynamics in Cancer
edited by Claudia Voena, Riccardo Taulli and Francesca Bersani
submission deadline 31 Jul 2026 | Viewed by 202 | Submission Open
Keywords: cancer signaling; cancer biology; tumor microenvironment; tumor progression; biomarkers; therapeutics
(This special issue belongs to the Section Cell Signaling)
Recent Advances in Vitamin D and K in Cancer submission deadline 31 Jul 2026 | Viewed by 195 | Submission Open
Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance
Advances in Maternal–Fetal Immunity
edited by
submission deadline 31 Jul 2026 | Viewed by 195 | Submission Open
Keywords: maternal– fetal immunity; developmental immunoregulation; pregnancy immune plasticity; fetal programming; pregnancy immunology
(This special issue belongs to the Section Reproductive Cells and Development)
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