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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Strategies in Osteosarcoma: Cell Biology, Biomarkers, and Immunotherapy

edited by

Frédéric Lézot

submission deadline 1 Oct 2026 | 1 articles | Viewed by 537 | Submission Open

Keywords: osteosarcoma; biomarkers; immunotherapy; metastasis; resistance

(This special issue belongs to the Section Cellular Pathology)

Advances in Matrix Metalloproteinase Research for Cancer Detection and Therapy

edited by Neha Atale, Vibha Rani and

Alireza Shoari

submission deadline 1 Oct 2026 | Viewed by 252 | Submission Open

Keywords: cancer; chemotherapy; EMT (epithelial to mesenchymal transition); matrix metalloproteinase; metastasis; metalloproteinase inhibitors; natural MMP inhibitors; tumor microenvironment

Human Brain Development: Insights from Experimental and Stem Cell-Based Models

edited by Nicole Amberg

submission deadline 1 Oct 2026 | Viewed by 117 | Submission Open

Keywords: progenitor cells; neurons; glia; regional identity; neurodevelopmental disorders; cerebral organoids; iPSCs

(This special issue belongs to the Section Cellular Neuroscience)

Mitochondria: Multifaceted Regulators of Cell Death

edited by Rasa Banienė and Sonata Trumbeckaite

submission deadline 10 Oct 2026 | Viewed by 373 | Submission Open

Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer

New Advances in Proteomics for Understanding Health and Disease

edited by

Syed Azmal Ali

submission deadline 10 Oct 2026 | Viewed by 234 | Submission Open

Keywords: mass spectrometry; single-cell proteomics; plasma proteomics; systems biology; cancer biology; health and disease; precision medicine; protein networks; clinical proteomics; multi-omics integration

(This special issue belongs to the Section Cell Methods)

Integrating Advanced Cellular Models in Radiation Biology: From Electromagnetic Fields to Photons and Emerging Particle Modalities

edited by

Mihaela Temelie

and

Diana Savu

submission deadline 10 Oct 2026 | Viewed by 194 | Submission Open

Keywords: ionizing radiation; particle radiation; electromagnetic; radiation biology; cell cultures; preclinical models

(This special issue belongs to the Section Cellular Biophysics)

Latest Advances in Molecular and Cellular Mechanisms of Alzheimer's Disease in Canada

edited by

Jacques P. Tremblay

submission deadline 10 Oct 2026 | Viewed by 191 | Submission Open

Keywords: Alzheimer's disease; neurodegeneration; amyloid-beta; protein aggregation; chaperone proteins; neuroinflammation; cerebrovascular system; CD2AP; blood– brain barrier; cholinergic neurons; neuronal regeneration; gut– brain axis; GSK3; BACE1; CD33 isoforms; translational neuroscience

(This special issue belongs to the Section Cellular Neuroscience)

The Effects of Stress on Cells and Organisms

edited by

Laura Fanti

Maria Giuseppina Bozzetti

and

Maurizio Trovato

submission deadline 10 Oct 2026 | Viewed by 134 | Submission Open

Keywords: stress; biological stress; stress response; TEs activity following stress; heat-shock proteins; epigenetic control of the stress; stress granules; alteration of metabolism following stress; stress adaptation; stress-related diseases

Advances in Zebrafish Disease Models

edited by

Natalia Kasica

and

Jaroslaw Widelski

submission deadline 15 Oct 2026 | 4 articles | Viewed by 10855 | Submission Open

Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders

Molecular and Cellular Insights into Platelet Function, 2nd Edition

edited by

Stepan Gambaryan

and

Mikhail A. Panteleev

submission deadline 15 Oct 2026 | 5 articles | Viewed by 5887 | Submission Open

Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity

T Cells in Inflammation and Cancer

edited by

Kihong Lim

submission deadline 15 Oct 2026 | 2 articles | Viewed by 5653 | Submission Open

Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Cellular Mechanisms in Pregnancy and Foetal Development

edited by

Anya L. Arthurs

and

Giovanni Levi

submission deadline 15 Oct 2026 | 3 articles | Viewed by 4898 | Submission Open

Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth

Gut Dysbiosis in Inflammatory Diseases

edited by Weiwei Liu

submission deadline 15 Oct 2026 | 2 articles | Viewed by 4024 | Submission Open

Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation

(This special issue belongs to the Section Cellular Pathology)

The Artificial Intelligence to the Rescue of Cancer Research

edited by

Asunción Espinosa-Sánchez

and

Amancio Carnero

submission deadline 15 Oct 2026 | 1 articles | Viewed by 2615 | Submission Open

Keywords: cancer research; artificial intelligence; personalized medicine; multi-omics data integration; AI-driven drug discovery; precision medicine

(This special issue belongs to the Section Cell Methods)

Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies

edited by

Christoph Beisswenger

and

Daniela Yildiz

submission deadline 15 Oct 2026 | 1 articles | Viewed by 2480 | Submission Open

Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing

Cellular and Molecular Studies of the Adrenal Gland

edited by Wen-Jun Shen,

Fredric B. Kraemer

and Salman Azhar

submission deadline 15 Oct 2026 | Viewed by 312 | Submission Open

Keywords: adrenal zonation; steroid hormones; steroidogenesis; congenital adrenal hyperplasia; hyperaldosteronism; Cushing’ s syndrome

Molecular and Cellular Mechanisms of Inherited Retinal Dystrophies

edited by Rosellina Guarascio,

Almudena Sacristán-Reviriego

and

Kalliopi Ziaka

submission deadline 15 Oct 2026 | Viewed by 105 | Submission Open

Keywords: retinal degeneration; photoreceptors; RPE; phototransduction; connecting cilium; retinoid cycle; protein folding; inflammation; oxidative stress; light damage

(This special issue belongs to the Section Cellular Pathology)

Regenerative Medicine for Bone and Dental Tissues: Biology and Applications

edited by

Pedro de Sousa Gomes

submission deadline 15 Oct 2026 | Viewed by 90 | Submission Open

Keywords: bone regeneration; dental tissue regeneration; stem and progenitor cells; biomaterials and bioactive scaffolds; translational regenerative strategies

(This special issue belongs to the Section Tissues and Organs)

Age-Related Macular Degeneration (AMD): From Cellular and Molecular Mechanisms to Therapies

edited by

Sujoy Bhattacharya

submission deadline 15 Oct 2026 | Viewed by 77 | Submission Open

Keywords: age‑related macular degeneration; cellular mechanism; molecular mechanism; gene therapies; neuroprotective strategies

(This special issue belongs to the Section Cellular Aging)

Advances in Muscle Research in Health and Disease—2nd Edition

edited by

Wan Lee

submission deadline 20 Oct 2026 | 4 articles | Viewed by 12119 | Submission Open

Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target

(This special issue belongs to the Section Tissues and Organs)

Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance

edited by

Xinyu Wang

Lei Zhu

and Yuancheng Li

submission deadline 20 Oct 2026 | 4 articles | Viewed by 10231 | Submission Open

Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product

(This special issue belongs to the Section Cell Microenvironment)

Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities

edited by

Sherri R. Cervantes

and

Daruka Mahadevan

submission deadline 20 Oct 2026 | 3 articles | Viewed by 4556 | Submission Open

Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer

(This special issue belongs to the Section Cell Microenvironment)

From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria

edited by Amy H. Attaway and Saurabh Mishra

submission deadline 20 Oct 2026 | 2 articles | Viewed by 3269 | Submission Open

Keywords: mitochondrial oxidation; ROS; aging; disease

Vascular Biology: From Molecular Mechanisms to Precision Therapies

edited by Payaningal R. Somanath

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1527 | Submission Open

Keywords: angiogenesis; endothelium; vascular permeability; blood– tissue barrier; organ injury

PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition

edited by

Jean Christopher Chamcheu

Claudia Bürger

and

Shile Huang

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1012 | Submission Open

Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics

Exclusive Review Papers in 'Cellular Biophysics'

edited by

Roger Schneiter

submission deadline 20 Oct 2026 | Viewed by 208 | Submission Open

Keywords: cellular biophysics; membrane biophysics; cytoskeletal dynamics; cellular mechanics; mechanotransduction; phase separation; molecular motors; bioelectricity; single-molecule techniques; computational biophysics; mechanobiology; active matter

(This special issue belongs to the Section Cellular Biophysics)

Cellular Pathophysiology of Intensive Care Unit-Acquired Muscle Dysfunction

edited by Lars Larsson

submission deadline 20 Oct 2026 | Viewed by 149 | Submission Open

Keywords: intensive care unit-acquired weakness; ventilator-induced diaphragm dysfunction; skeletal muscle atrophy; protein degradation; mitochondrial dysfunction; JAK-STAT signaling; oxidative stress; critical illness myopathy; autophagy; muscle proteostasis

(This special issue belongs to the Section Cellular Pathology)

New Advances and Perspectives in the Molecular Mechanisms of Aging and Skin Cancer: Potential Options for Prevention and Treatment

edited by

Goberdhan P. Dimri

and Ewelina Musielak

submission deadline 20 Oct 2026 | Viewed by 93 | Submission Open

Keywords: skin cancer; malignancy; melanoma; non-melanoma; prevention; skin aging; skin photo-aging; skin inflammation; treatment; inflammaging; immune dysfunction; senescent cell

(This special issue belongs to the Section Cellular Aging)

Polyadenylation-Mediated Regulation of Pulmonary Diseases

edited by

Tingting Weng-Mills

submission deadline 20 Oct 2026 | Viewed by 70 | Submission Open

Keywords: polyadenylation; lung remodeling; pulmonary fibrosis; epitranscriptomics; alveolar epithelial cells

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses

edited by

Geeta Upadhyay

submission deadline 22 Oct 2026 | 1 articles | Viewed by 383 | Submission Open

Keywords: anti-tumor immunity; immunotherapy; immune checkpoint blockade; immune receptor and ligand; immune evasion; tumor immune microenvironment; inflammation; T-cell activation and inhibition; myeloid-derived suppressor cell; macrophage; dendritic cell

(This special issue belongs to the Section Cellular Immunology)

The Dual Role of Extracellular Vesicles in Neurodegeneration: Disease Biomarkers and Drug Delivery Platforms Within the Matrix Microenvironment

edited by

Elisa Tonoli

and

Elisabetta Verderio Edwards

submission deadline 25 Oct 2026 | 1 articles | Viewed by 532 | Submission Open

Keywords: extracellular vesicles; neurodegenerative diseases; extracellular matrix; biomarkers; therapeutic applications; drug delivery

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Caveolae Function in Cell Membrane Dynamics and Signal Transduction

edited by

Alessio D'Alessio

and

Antonio Filippini

submission deadline 25 Oct 2026 | Viewed by 308 | Submission Open

Keywords: caveolae; caveolin and cavin proteins; plasma membrane organization; endocytosis and vesicular trafficking; mechanotransduction; lipid rafts and cholesterol metabolism; signal transduction; vascular biology and angiogenesis; cancer cell biology; membrane remodeling in disease

Vascular Microenvironment and Atherosclerosis

edited by

Abhijnan Chattopadhyay

and

Jacques P. Tremblay

submission deadline 25 Oct 2026 | Viewed by 106 | Submission Open

Keywords: vascular microenvironment; atherosclerosis; vascular inflammation; endothelial cells; smooth muscle cells; vascular– immune cell interactions; extracellular matrix; vascular remodeling; mechanotransduction; vascular biology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Tumor Microenvironment and Immune Regulation

edited by

Xin Liu

submission deadline 25 Oct 2026 | Viewed by 103 | Submission Open

Keywords: cellular immunology; tumor microenvironment; intra- and extracellular signaling; immunometabolism; experimental cytology; tumor-infiltrating lymphocytes; spatial transcriptomics

(This special issue belongs to the Section Cell Microenvironment)

Nuclear Receptors, Drug Discovery, Nutraceuticals, and Neurodegenerative Diseases

edited by Rajesh Haresh Amin,

Kristine Griffett

and Meenakshi Singh

submission deadline 25 Oct 2026 | Viewed by 98 | Submission Open

Keywords: nuclear receptors; neurodegenerative diseases; metabolic dysfunction; inflammation; drug design

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Advances in Annexin Biology

edited by

Raffaella Belvedere

Antonello Petrella

and Nunzia Novizio

submission deadline 28 Oct 2026 | 1 articles | Viewed by 1075 | Submission Open

Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets

Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders

edited by Janaína Sena de Souza

submission deadline 30 Oct 2026 | 6 articles | Viewed by 15962 | Submission Open

Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system

(This special issue belongs to the Section Cellular Neuroscience)

Advances in Reproductive Biology: Cellular and Molecular Mechanisms

edited by

Rosa Roy

and Clara González-Marín

submission deadline 30 Oct 2026 | 6 articles | Viewed by 9528 | Submission Open

Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations

(This special issue belongs to the Section Reproductive Cells and Development)

Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance

edited by

Yang Xu

and Ramkrishna Mitra

submission deadline 30 Oct 2026 | 3 articles | Viewed by 6904 | Submission Open

Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations

(This special issue belongs to the Section Cellular Pathology)

Translational Aspects of Cell Signaling

edited by

Marc D. Basson

submission deadline 30 Oct 2026 | 4 articles | Viewed by 5285 | Submission Open

Keywords: cell signaling; drug development; prognostic markers; bioinformatics; translational research

Mechanisms and Therapies of Cell Death Pathways

edited by

Evripidis Gavathiotis

and Deniz Gulfem Ozturk

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1865 | Submission Open

Keywords: cell death; mitochondrial regulation; BCL-2 family; non-apoptotic cell death; cell death pathways interactions; small molecules; therapeutic strategy; therapy resistance

(This special issue belongs to the Section Cellular Pathology)

New Therapeutic Approaches to Cardiac Repair

edited by Dinakar Iyer

submission deadline 30 Oct 2026 | 1 articles | Viewed by 765 | Submission Open

Keywords: cardiac regeneration; CRISPR/base editing; mRNA therapeutics; circular RNA (circRNA); lipid nanoparticles (LNPs); engineered exosomes/extracellular vesicles; direct cardiac reprogramming; engineered heart muscle/3D cardiac patches; myocardial infarction repair; translational cardiology

Extracellular Vesicles in Chronic Obstructive Pulmonary Disease: A 2025 Update

edited by

Tommaso Neri

and

Erica Bazzan

submission deadline 30 Oct 2026 | Viewed by 343 | Submission Open

Keywords: extracellular vesicles (EVs); chronic obstructive pulmonary disease (COPD); inflammation; epithelial barrier; cellular senescence; tissue remodeling; biomarkers; exacerbations; microbiota; therapeutic targets

Mechanism of Endocrine Therapy Resistance in Breast Cancer

edited by

Debra A. Tonetti

and Clodia Osipo

submission deadline 30 Oct 2026 | Viewed by 317 | Submission Open

Keywords: estrogen receptor; endocrine resistance; mechanism of action; predictive biomarkers; signal transduction; novel therapeutics; drug sequencing; drug targets; pathological findings

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Basis in Chronic Kidney Disease—2nd Edition

edited by

Prabhatchandra Dube

and Dulat Bekbolsynov

submission deadline 30 Oct 2026 | Viewed by 157 | Submission Open

Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria

(This special issue belongs to the Section Cellular Pathology)

Gut Microbiota as a Regulator and Target in Cancer Immunology

edited by

Suresh Veeraperumal

and Pazhanichamy Kalailingam

submission deadline 30 Oct 2026 | Viewed by 113 | Submission Open

Keywords: gut microbiota; cancer immunology; tumor microenvironment; immune checkpoint inhibitors; cellular immunotherapy; tumor infiltrating lymphocytes; dysbiosis; microbiota targeted therapy; microbiome biomarkers; immunotherapy resistance

(This special issue belongs to the Section Cellular Immunology)

Decoding Melanoma: Molecular and Cellular Mechanisms and Therapeutic Opportunities

edited by

Cynthia Simbulan-Rosenthal

and

Anirudh Gaur

submission deadline 30 Oct 2026 | Viewed by 89 | Submission Open

Keywords: translational oncology; tumor biology; melanoma-targeted therapy; precision medicine; biomarker discovery

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms of Leukemia

edited by Xiangguo Shi

submission deadline 30 Oct 2026 | Viewed by 79 | Submission Open

Keywords: leukemia; genomics; epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration

edited by

Philippe Hernigou

submission deadline 31 Oct 2026 | 7 articles | Viewed by 17703 | Submission Open

Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique

(This special issue belongs to the Section Cellular Pathology)

Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects

edited by

Markus Mandl

submission deadline 31 Oct 2026 | 1 articles | Viewed by 4252 | Submission Open

Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics

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