In Honor of Nobel Prize in Physiology or Medicine: Cell-Mediated Immunity

Dear Colleagues,

For over 100 years, ground-breaking results of immunological research have been awarded with the Nobel Prize in Physiology or Medicine. Nobel Prizes have been awarded for outstanding research on various aspects of humoral immunity including the complement system (Bordet, 1919), the chemical structure of antibodies (Edelman and Porter, 1972), the immune network and the discovery of monoclonal antibodies (Jerne, Köhler and Milstein, 1984), and the discovery of somatic gene rearrangement during antibody formation (Tonegawa, 1987).

The current Special Issue of Cells is devoted to the memory of ground-breaking research in cellular immunology, and how such discoveries have paved the way for today’s understanding of cell-mediated immunity controlling innate and adaptive immune responses. Such milestones include the discovery of macrophages (Metchnikoff, Nobel Prize together with Ehrlich in 1908), the conceptualization of immunological tolerance (Medawar and Macfarlane Burnett, 1960), the discovery of MHC molecules (Benacerraf, Dausset and Snell, 1980), the discovery of MHC-restricted T-cell antigen recognition (Doherty and Zinkernagel, 1996), the identification of innate immune receptors and the role of dendritic cells (Beutler, Hoffmann and Steinman, 2011), and the recent recognition of the importance of negative immune regulation in cancer therapy (Allison and Honjo, 2018).

This Special Issue aims to collect papers in the field of cellular immunology with a focus on articles that illustrate how early ground-breaking work awarded with a Nobel Prize has influenced top-notch research until the present day. In this sense, we welcome articles dealing with immune cells and their role in innate and adaptive immunity.

Prof. Dr. Dieter Kabelitz
Guest Editor

Manuscript Submission Information

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