CRISPR/Cas9-Mediated Gene Therapy in Cancer

Dear Colleagues,

The advent of cutting-edge CRISPR/Cas-based gene editing techniques and related therapeutic applications comes with an unprecedented opportunity to treat monogenic diseases, even complex diseases like cancers. The CRISPR/Cas-based gene therapy for different types of cancers requires the careful engineering of genome-editing toolsets, delivery strategies, spatiotemporal control of Cas protein expression, off-target mitigation, and efforts to address cytotoxicity and immunogenicity. These therapeutic approaches greatly vary between liquid tumors and solid-state tumors. More mechanistic and translational research will be beneficial for knowledge base advancement regarding this breakthrough gene therapy technique. Thus, in this Special Issue, we invite you to submit your original research articles and review articles discussing about diverse components of CRISPR/Cas-based gene therapy. These include, but are not limited to:

1. The choice of CRISPR/Cas system for safer cancer gene therapy;
2. Spatio-temporal control of gene regulation in cancers through CRISPR/Cas;
3. Controlling Cas protein expression in in vivo gene therapy application;
4. Viral and non-viral delivery system;
5. Application of CAR-T cell therapy in liquid and solid-state tumors;
6. Engineering natural killer (NK) cells for cancer immunotherapy;
7. Strategies to mitigate cytotoxicity and immunotoxicity in CRISPR/Cas gene therapy.

Dr. Tong-Chuan He
Dr. Subhajit Giri
Dr. Sharad Awasthi
Guest Editors

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