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  • Review
  • Open Access
21 Citations
9,651 Views
30 Pages

29 July 2021

The tremendously rising numbers of aged populations are associated with a heightened risk for motor and functional declines. Sarcopenia is an active age-related process that involves progressive losses of skeletal muscle mass, muscle strength, and mu...

  • Review
  • Open Access
19 Citations
8,736 Views
10 Pages

30 May 2023

Machine learning is being increasingly applied in various aspects of medicine. The availability of large amounts of digital health records has enabled researchers to apply machine learning algorithms to tackle different medical problems. Urinary trac...

  • Opinion
  • Open Access
18 Citations
13,399 Views
16 Pages

30 May 2023

The COVID crisis of the past three years has greatly impacted stakeholder relationships between scientists, health providers, policy makers, pharmaceutical industry employees, and the public. Lockdowns and restrictions of civil liberties strained an...

  • Review
  • Open Access
17 Citations
8,001 Views
11 Pages

Relationships between Oral Health and the Sustainable Development Goals: A Scoping Review

  • Olunike Rebecca Abodunrin,
  • Mobolaji Timothy Olagunju,
  • Omolola Titilayo Alade and
  • Morẹ́nikẹ́ Oluwátóyìn Foláyan

30 October 2023

The aim of this scoping review was to map the research that links oral health and sustainable development goals (SDGs). The question that guided this review was what is the published evidence specifically linking oral health and SDGs? The search of a...

  • Article
  • Open Access
17 Citations
11,641 Views
9 Pages

Observational Study on the Success Rate of Osseointegration: A Prospective Analysis of 15,483 Implants in a Public Health Setting

  • Butruz Sarkis Simão,
  • Denis Damião Costa,
  • Maria Cristina Teixeira Cangussu,
  • Bruno Salles Sotto-Maior and ,
  • Renan Lana Devita,
  • Jorge José de Carvalho and
  • Igor da Silva Brum
  • + 2 authors+ 0 author

28 November 2022

The osseointegration process between the host’s bone tissue and the titanium implant is the key to success of implantology. The literature highlights the high success rate of osseointegrated implants, which is above 90%, and warns that some fai...

  • Article
  • Open Access
17 Citations
6,989 Views
12 Pages

19 January 2023

The present work presents evaluation and experimental verification of the use of X-ray computed tomographic microscopy (micro-CT) for accurate characterization of geometry, microarchitecture, and stiffness properties of bones. These properties are cr...

  • Opinion
  • Open Access
16 Citations
10,193 Views
9 Pages

Untreated Early Childhood Caries and Possible Links with Brain Development

  • Morẹ́nikẹ́ Oluwátóyìn Foláyan,
  • Omowumi Moromoke Femi-Akinlosotu,
  • Bolu Adeoti and
  • Oluwatosin Eunice Olorunmoteni

28 September 2023

Untreated early childhood caries (ECC) is a global public health concern. In the short term, untreated ECC can lead to pain, infection, and disrupted sleep, among other issues. In the long term, it is associated with poor oral health in later life, i...

  • Systematic Review
  • Open Access
14 Citations
10,345 Views
20 Pages

A Scoping Review on Coping Strategies and Quality of Life of Stroke Caregivers: Often Underestimated Variables in Stroke Recovery Process?

  • Anna Tsiakiri,
  • Pinelopi Vlotinou,
  • Aikaterini Paschalidou,
  • Christos Konstantinidis and ,
  • Foteini Christidi,
  • Dimitrios Tsiptsios,
  • Georgia Detsaridou,
  • Alexandra Petridou,
  • Aimilios Gkantzios and
  • Nikolaos Aggelousis
  • + 10 authors+ 5 authors

18 July 2023

The purpose of the present study was to review all available work published within the last decade focusing on coping strategies in stroke caregivers and their impact on quality of Life (QoL) and psycho-emotional status. A literature search of two da...

  • Article
  • Open Access
14 Citations
4,382 Views
25 Pages

Advancing Brain MRI Image Classification: Integrating VGG16 and ResNet50 with a Multi-Verse Optimization Method

  • Nazanin Tataei Sarshar,
  • Soroush Sadeghi,
  • Mohammadreza Kamsari,
  • Mahrokh Avazpour and ,
  • Saeid Jafarzadeh Ghoushchi and
  • Ramin Ranjbarzadeh
  • + 1 author+ 0 author

24 November 2024

Background/Objectives: The accurate categorization of brain MRI images into tumor and non-tumor categories is essential for a prompt and effective diagnosis. This paper presents a novel methodology utilizing advanced Convolutional Neural Network (CNN...

  • Article
  • Open Access
14 Citations
7,526 Views
16 Pages

Phytochemical Composition, In Silico Molecular Docking Analysis and Antibacterial Activity of Lawsonia inermis Linn Leaves Extracts against Extended Spectrum Beta-Lactamases-Producing Strains of Klebsiella pneumoniae

  • Adam Mustapha,
  • Ahmed Nouri AlSharksi,
  • Ukpai A. Eze,
  • Rahma Kudla Samaila and ,
  • Boniface Nwofoke Ukwah,
  • Arinze Favour Anyiam,
  • Shivanthi Samarasinghe and
  • Musa Adamu Ibrahim
  • + 3 authors+ 0 author

26 August 2024

Klebsiella pneumoniae is an opportunistic Gram-negative bacterium in the Enterobacteriaceae family associated with a wide range of diseases, such as pneumonia, bloodstream infections, meningitis and urinary tract infections. Infections caused by drug...

  • Review
  • Open Access
12 Citations
8,035 Views
20 Pages

Machine Learning Techniques for the Prediction of Functional Outcomes in the Rehabilitation of Post-Stroke Patients: A Scoping Review

  • Christos Kokkotis,
  • Serafeim Moustakidis,
  • Georgios Giarmatzis,
  • Erasmia Giannakou and ,
  • Evangelia Makri,
  • Paraskevi Sakellari,
  • Dimitrios Tsiptsios,
  • Stella Karatzetzou,
  • Foteini Christidi and
  • Nikolaos Aggelousis
  • + 6 authors+ 1 author

27 December 2022

Stroke is one of the main causes of long-term disabilities, increasing the cost of national healthcare systems due to the elevated costs of rigorous treatment that is required, as well as personal cost because of the decreased ability of the patient...

  • Review
  • Open Access
12 Citations
17,561 Views
14 Pages

14 May 2024

The purpose of this review is to elucidate the different laboratory and biomarker testing methods available for screening and diagnosis of preeclampsia. These include routine testing, such as blood pressure readings, qualitative and quantitative urin...

  • Communication
  • Open Access
11 Citations
6,864 Views
7 Pages

14 March 2023

The SARS-CoV2 pandemic is the most significant global health emergency of the last century. While the pathophysiology of SARS-CoV2 is understood, the early and long-term outcomes of natural infection are increasingly being recognised. Multisystem inf...

  • Systematic Review
  • Open Access
11 Citations
5,398 Views
21 Pages

Cardiometabolic Risk Factors Among African University Students: A Systematic Review

  • Jude Eteneneng Enoh,
  • Roland Tiagha Akah and
  • Benedicta Nkeh-Chungag

27 December 2024

Background: Cardiometabolic risk factors such as hypertension, overweight, and obesity have become increasingly common among African students who tend to become more sedentary in urban environments. This systematic review aimed to determine and ident...

  • Systematic Review
  • Open Access
11 Citations
20,142 Views
13 Pages

10 August 2022

Football is characterized as a contact sport that increases the risk of injury. For the reduction of injuries, health care providers created a warm-up program that is called the FIFA11+. This is a 20 min warm-up program that has the goal of preventin...

  • Article
  • Open Access
10 Citations
8,874 Views
9 Pages

21 November 2023

Mandibular third molars are the most commonly impacted teeth. The prevalence and pattern of impacted mandibular third molars in patients presenting to the Obafemi Awolowo University Teaching Hospitals Complex, a tertiary hospital in south-western Nig...

  • Article
  • Open Access
10 Citations
5,765 Views
18 Pages

Decreased Effectiveness of a Novel Opioid Withdrawal Protocol Following the Emergence of Medetomidine as a Fentanyl Adulterant

  • Kory S. London,
  • Philip Durney,
  • TaReva Warrick-Stone,
  • Karen Alexander and
  • Jennifer L. Kahoud

23 May 2025

Background/Objectives: Philadelphia has experienced a surge in illicit fentanyl adulterated with alpha-2 agonist sedatives. Initially, xylazine (“tranq”) was the predominant adulterant, and a novel multimodal withdrawal protocol was effec...

  • Review
  • Open Access
10 Citations
8,054 Views
29 Pages

Synthesis and Characterization of Carbonaceous Materials for Medical Applications: A Comprehensive Review

  • Ebenezer C. Nnadozie,
  • Kennedy I. Ogunwa,
  • Vitalis I. Chukwuike,
  • Onyinyechukwu O. Nnadozie and
  • Charles Ehikhase

2 November 2024

Carbonaceous materials have gained significant attention in recent years for their various applications in the field of medicine and biotechnology. This comprehensive review explores the synthesis and characterization of carbon-based materials and th...

  • Article
  • Open Access
10 Citations
6,456 Views
12 Pages

Phenotypic Characterization and Prevalence of Carbapenemase-Producing Pseudomonas aeruginosa Isolates in Six Health Facilities in Cameroon

  • Cecile Ingrid Djuikoue,
  • Paule Dana Djouela Djoulako,
  • Hélène Valérie Same Njanjo,
  • Christiane Possi Kiyang and ,
  • Feline Leina Djantou Biankeu,
  • Celianthe Guegang,
  • Andrea Sheisley Didi Tchouotou,
  • Rodrigue Kamga Wouambo,
  • Benjamin D. Thumamo Pokam and
  • Katy Jeannot
  • + 6 authors+ 1 author

12 January 2023

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen with a great ability to adapt to stress, in particular, to the selective pressure of antibiotics in the hospital environment. This pathogen constitutes a real public health concern, esp...

  • Article
  • Open Access
10 Citations
6,312 Views
7 Pages

Association between Height and Hypertension: A Retrospective Study

  • Yuji Shimizu,
  • Hidenobu Hayakawa,
  • Nagisa Sasaki,
  • Midori Takada and ,
  • Takeo Okada and
  • Masahiko Kiyama
  • + 1 author+ 0 author

25 July 2022

Height loss starting in middle age is reported to be an independent risk factor for cardiovascular mortality. Recent studies have revealed an inverse association between height and hypertension, but the influence of hypertension on height loss is unk...

  • Review
  • Open Access
10 Citations
6,740 Views
17 Pages

25 July 2024

Amid the global health crisis instigated by COVID-19, the resurgence of tuberculosis (TB) has underscored the urgent need for innovative solutions. With TB claiming 1.6 million lives in 2021, it remains a formidable challenge, particularly in underde...

  • Review
  • Open Access
9 Citations
5,926 Views
18 Pages

Oral Diseases and Adverse Pregnancy Outcomes in Sub-Saharan Africa: A Scoping Review

  • Ezekiel Taiwo Adebayo,
  • Olunike Rebecca Abodunrin,
  • Ifeoluwa E. Adewole,
  • Abideen Olurotimi Salako and ,
  • Joanne Lusher,
  • Folahanmi Tomiwa Akinsolu,
  • Maha El Tantawi,
  • Omolola Titilayo Alade,
  • George Uchenna Eleje and
  • Moréniké Oluwátóyìn Foláyan
  • + 6 authors+ 1 author

29 December 2023

This scoping review mapped and critically reviewed the extant literature exploring associations between oral disease status and adverse pregnancy outcomes among women residing in sub-Saharan Africa. A literature search was conducted in July 2023 usin...

  • Perspective
  • Open Access
9 Citations
11,068 Views
12 Pages

8 June 2022

This article provides arguments for and against the classification of low back pain (LBP) as a disease or health condition. Based on the basic definitions of health, disease, illness, sickness, infirmity, and pain, little support has been found for t...

  • Article
  • Open Access
8 Citations
4,858 Views
12 Pages

COVID-19 Prognosis and Mortality Risk Predictions from Symptoms: A Cloud-Based Smartphone Application

  • Ocean Monjur,
  • Rahat Bin Preo,
  • Abdullah Bin Shams,
  • Md. Mohsin Sarker Raihan and
  • Fariha Fairoz

29 November 2021

The coronavirus pandemic overwhelmed many countries and their healthcare systems. Shortage of testing kits and Intensive-Care-Unit (ICU) beds for critical patients have become a norm in most developing countries. This has prompted the need to rapidly...

  • Review
  • Open Access
8 Citations
13,972 Views
18 Pages

10 March 2023

Recently, in Italy, a flowchart to be used by General Practitioners for the at-home treatment of patients with COVID-19, has been released. It states that early at-home treatment for SARS-CoV-2 infection is possible due to the availability of specifi...

  • Review
  • Open Access
8 Citations
12,788 Views
40 Pages

Review of Multimodal Data Acquisition Approaches for Brain–Computer Interfaces

  • Sayantan Ghosh,
  • Domokos Máthé,
  • Purushothaman Bhuvana Harishita,
  • Pramod Sankarapillai and ,
  • Anand Mohan,
  • Raghavan Bhuvanakantham,
  • Balázs Gulyás and
  • Parasuraman Padmanabhan
  • + 3 authors+ 0 author

2 December 2024

There have been multiple technological advancements that promise to gradually enable devices to measure and record signals with high resolution and accuracy in the domain of brain–computer interfaces (BCIs). Multimodal BCIs have been able to ga...

  • Review
  • Open Access
8 Citations
4,641 Views
13 Pages

Understanding Post-Stroke Movement by Means of Motion Capture and Musculoskeletal Modeling: A Scoping Review of Methods and Practices

  • Georgios Giarmatzis,
  • Styliani Fotiadou,
  • Erasmia Giannakou,
  • Christos Kokkotis and ,
  • Theodora Fanaradelli,
  • Souzanna Kordosi,
  • Konstantinos Vadikolias and
  • Nikos Aggelousis
  • + 3 authors+ 0 author

16 November 2022

Research of post-stroke locomotion via musculoskeletal (MSK) modeling has offered an unprecedented insight into pathological muscle function and its interplay with skeletal geometry and external stimuli. Advances in solving the dynamical system of po...

  • Review
  • Open Access
8 Citations
5,412 Views
18 Pages

12 April 2022

The outbreak of coronavirus disease (COVID-19), which comes with several comorbidities, was declared a pandemic in early 2020 by World Health Organization (WHO). Glucocorticoids that are used in severe cases of COVID-19 as therapeutic measures may le...

  • Review
  • Open Access
8 Citations
27,689 Views
17 Pages

29 September 2022

Patellar tendinopathy is a common injury characterized by progressive activity-related anterior knee pain. It is highly prevalent in sports which involve jumping and changing direction. The aim of this paper is to review recent high-quality evidence...

  • Review
  • Open Access
8 Citations
8,998 Views
20 Pages

5 September 2024

Overuse or misuse of broad-spectrum antibiotics increases the risk of the emergence of antibiotic-resistant bacteria, which increases the possibility of antimicrobial-resistant (AMR) bacterial infections, and subsequently raises healthcare costs. The...

  • Article
  • Open Access
7 Citations
6,791 Views
18 Pages

Estimates of the COVID-19 Infection Fatality Rate for 48 African Countries: A Model-Based Analysis

  • Amobi Andrew Onovo,
  • Abiye Kalaiwo,
  • Christopher Obanubi,
  • Gertrude Odezugo and ,
  • Janne Estill and
  • Olivia Keiser
  • + 1 author+ 0 author

10 September 2021

(1) Background: Examine global data from 48 African countries to estimate the SARS-CoV-2 infection fatality rate; (2) Methods: We analyzed time series data on the 135,126 confirmed cases and 3922 deaths from COVID-19 disease outbreak in Africa throug...

  • Article
  • Open Access
7 Citations
9,797 Views
11 Pages

HHV-6 in Cerebrospinal Fluid in Immunocompetent Children

  • Mikhail A. Nikolskiy,
  • Dmitriy A. Lioznov,
  • Evgeniy U. Gorelik and
  • Tatyana V. Vishnevskaya

20 September 2023

Background: Human herpes virus-6 (HHV-6) is a ubiquitous virus known as an etiological agent of exanthem subitum. HHV-6-encephalitis in immunocompetent children is a rare complication of the primary infection. There are a lack of data on the prevalen...

  • Review
  • Open Access
7 Citations
6,428 Views
28 Pages

16 April 2022

Obesity in America is a public health crisis that will continue to impact the country at an individual, social, and economic level unless we address the disease with dietary modifications to reduce or prevent its development. Nutritional intervention...

  • Review
  • Open Access
7 Citations
8,005 Views
14 Pages

Mast Cell Tryptase and Implications for SARS-CoV-2 Pathogenesis

  • Negar Karimi,
  • Solmaz Morovati,
  • Lily Chan,
  • Christina Napoleoni and ,
  • Yeganeh Mehrani,
  • Byram W. Bridle and
  • Khalil Karimi
  • + 2 authors+ 0 author

17 December 2021

Mast cells (MCs) are heterogenous innate leukocytes producing many inflammatory mediators during viral infections that can be protective or damaging to the host, as is seen in the infection with the severe acute respiratory syndrome coronavirus 2 (SA...

  • Brief Report
  • Open Access
6 Citations
3,576 Views
7 Pages

23 February 2022

Background: Recent studies have highlighted the relationship between EDs and COVID-19 and have shown how the change in daily dynamics and lifestyle together with the forced isolation regime have worked as psychopathological risk factors. Prolonged is...

  • Systematic Review
  • Open Access
5 Citations
4,488 Views
10 Pages

Acute Vessel Closure or Major Adverse Cardiac Events of Drug-Coated Balloons and Stents: A Systematic Review and Meta-Analysis

  • Tharusha Gunawardena,
  • Natasha Corballis,
  • Ioannis Merinopoulos,
  • Vasiliki Tsampasian and ,
  • Johannes Reinhold,
  • Simon Eccleshall and
  • Vassilios S. Vassiliou
  • + 2 authors+ 0 author

15 December 2022

While the use of drug-eluting stents (DES) has become the first-line strategy for treating coronary artery disease, there are still drawbacks with their use. As our understanding of coronary artery anatomy and physiology evolves, growing evidence sup...

  • Review
  • Open Access
5 Citations
7,541 Views
11 Pages

30 March 2022

The global prevalence of diabetes exceeds half a billion people globally. The Diabetes Prevention Program, a 27-site, randomized clinical trial demonstrated that dietary and other lifestyle changes can prevent more than half (58%) of diabetes cases....

  • Opinion
  • Open Access
5 Citations
4,566 Views
10 Pages

Cognitive Function and Neuropsychiatric Disorders after COVID-19: A Long Term Social and Clinical Problem?

  • José M. Ramírez-Moreno,
  • Agustín Muñoz-Sanz and
  • Francisco J. Vaz-Leal

24 January 2022

SARS-CoV-2 is one more virus that can affect the brain in one way or another. Now, we are only beginning to understand some mechanisms and the degree to which it can impact the nervous system. Considering the rapid accumulation of knowledge about mul...

  • Article
  • Open Access
5 Citations
12,295 Views
11 Pages

7 April 2024

Practitioners routinely use the single leg heel raise (SLHR) to quantify calf function in healthy and injured populations. Despite this, approaches vary and the impact of cueing on SLHR performance and results interpretation in athletesis unknown. Th...

  • Review
  • Open Access
5 Citations
6,105 Views
10 Pages

Assistive Communication Devices in Rett Syndrome: A Case Report and Narrative Review

  • Justin Lee,
  • Jessica Lee,
  • Mouath Abu-Daoud and
  • Yazan A. Al-Ajlouni

27 May 2024

Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily affecting females, characterized by developmental regression and significant communication impairments. Despite the critical role of communication in maintaining quality of life, t...

  • Technical Note
  • Open Access
4 Citations
4,445 Views
9 Pages

Covid19Risk.ai: An Open Source Repository and Online Calculator of Prediction Models for Early Diagnosis and Prognosis of Covid-19

  • Iva Halilaj,
  • Avishek Chatterjee,
  • Yvonka van Wijk,
  • Guangyao Wu and ,
  • Brice van Eeckhout,
  • Cary Oberije and
  • Philippe Lambin
  • + 2 authors+ 0 author

20 August 2021

Background: The current pandemic has led to a proliferation of predictive models being developed to address various aspects of COVID-19 patient care. We aimed to develop an online platform that would serve as an open source repository for a curated s...

  • Communication
  • Open Access
4 Citations
2,080 Views
8 Pages

A Longitudinal Assessment of Substance Use Treatment during the COVID-19 Pandemic Using Staff and Service Data

  • Molly Carlyle,
  • Grace Newland,
  • Leith Morris,
  • Rhiannon Ellem and ,
  • Calvert Tisdale,
  • Catherine A. Quinn and
  • Leanne Hides
  • + 2 authors+ 0 author

4 April 2023

Introduction: Alcohol and other drug (AOD) treatment services were required to rapidly adapt delivery of care in response to the coronavirus (COVID-19) pandemic. This study examined longitudinal changes in the delivery of AOD counselling in Australia...

  • Review
  • Open Access
4 Citations
14,325 Views
17 Pages

20 February 2023

The acute rupture of the Achilles tendon is an increasingly common injury due to an active lifestyle and participation in sports, especially in the middle-aged group. We conducted a focused review of the literature and found that the acute rupture of...

  • Review
  • Open Access
4 Citations
4,609 Views
27 Pages

6 June 2023

The rapid spread of the new coronavirus disease (COVID-19) caused by SARS-CoV-2 has become a global pandemic. Although specific vaccines are available and natural drugs are being researched, supportive care and specific treatments to alleviate sympto...

  • Perspective
  • Open Access
4 Citations
6,337 Views
6 Pages

18 February 2022

A COVID-19 smoker’s paradox was identified during the early days of the COVID-19 pandemic—many studies reported that smokers appeared to be protected against SARS-CoV-2 infections. Conversely, other studies added to the smoker’s par...

  • Article
  • Open Access
4 Citations
5,613 Views
17 Pages

The Secreted Metabolome of Hela Cells under Effect of Crotamine, a Cell-Penetrating Peptide from a Rattlesnake Using NMR-Based Metabolomics Analyses

  • Mônika Aparecida Coronado,
  • Fábio Rogério de Moraes,
  • Bruna Stuqui,
  • Marília Freitas Calmon and ,
  • Raphael Josef Eberle,
  • Paula Rahal and
  • Raghuvir Krishnaswamy Arni
  • + 2 authors+ 0 author

22 April 2022

Sequestering and reprogramming of cellular metabolism represents one of the principal hallmarks of several cells. Antimicrobial peptides have been shown to exhibit selective anticancer activities. In this study, the secreted metabolome of HeLa cells...

  • Article
  • Open Access
4 Citations
4,232 Views
13 Pages

27 January 2022

The outbreak of the COVID-19 epidemic has focused enormous attention on the genetics of viral infection and related disease. Since the beginning of the pandemic, we focused on the collection and integration of SARS-CoV-2 databases, which contain info...

  • Review
  • Open Access
4 Citations
4,935 Views
23 Pages

Application of the Hub-and-Spoke Model in Antimicrobial Stewardship Programmes: A Scoping Review

  • Ayesha Iqbal,
  • Yuhashinee Kumaradev,
  • Gizem Gülpinar,
  • Claire Brandish and ,
  • Maxencia Nabiryo,
  • Frances Garraghan,
  • Helena Rosado and
  • Victoria Rutter
  • + 3 authors+ 0 author

1 October 2024

Background: The hub-and-spoke model (HSM) offers a framework for efficient healthcare service delivery. This scoping review seeks to explore the implementation and effectiveness of the HSM in antimicrobial stewardship (AMS) programmes. Methods: The P...

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