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Reports, Volume 7, Issue 2

2024 June - 28 articles

Cover Story: This study estimated the prevalence of drug interactions with chloroquine (CQ) or hydroxychloroquine (HCQ) in COVID-19 inpatients during the pandemic waves and their association with hospitalization-related outcomes. In a sample of 487 patients with a mean age of 77.1 years (47.8% females), hospitalized for COVID-19 from March to December 2020, and treated with CQ or HCQ, we found that 255 (52.4%) had one drug interaction with CQ or HCQ, and 114 (23.4%) had ≥2 interactions. The most frequent drugs interacting with CQ or HCQ were lopinavir/ritonavir, azithromycin, tocilizumab, levofloxacin, clarithromycin, amlodipine, and trazodone. The presence of drug–drug interactions did not seem to impact the hospitalization duration and outcomes. View this paper
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Articles (28)

  • Case Report
  • Open Access
1 Citations
2,179 Views
10 Pages

Primary Melanoma of the Pineal Gland Case Report and Review of the Literature

  • Daniel Rotariu,
  • Bogdan F. Iliescu,
  • Gabriela Dumitrescu,
  • Antonia Nita and
  • Bogdan Costachescu

20 June 2024

Pineal-region tumors are a histologically heterogeneous group of tumors and represent a rare occurrence, accounting for less than 1% of all adult intracranial tumors. Among these, primary pineal malignant melanomas (PPM) represent an even rarer entit...

  • Case Report
  • Open Access
2,096 Views
6 Pages

Complete Left-Sided Pericardial Congenital Absence

  • Petar Kalaydzhiev,
  • Anelia Partenova,
  • Radostina Ilieva,
  • Kamelia Genova and
  • Elena Kinova

20 June 2024

Background: Congenital absence of pericardium is a rare cardiac disorder with a reported incidence of less than 1 in 10,000. Although most of the cases are of little clinical significance, some of them are associated with serious complications, inclu...

  • Case Report
  • Open Access
2,133 Views
6 Pages

14 June 2024

Background: Airway management in Duchenne patients can be challenging. We present a case of an anticipated difficult airway in a 24-year-old Duchenne patient that was managed by planning different suitable strategies based on the unanticipated diffic...

  • Case Report
  • Open Access
1 Citations
2,415 Views
6 Pages

Endoscopic Surgical Approach for a Mesiodens in the Nasal Cavity: A Rare Phenomenon

  • Enzo Iacomino,
  • Chiara Fratini,
  • Federica Zoccali,
  • Francesca Cambria,
  • Matteo Laudani,
  • Alberto Eibenstein,
  • Christian Barbato,
  • Marco de Vincentiis and
  • Antonio Minni

13 June 2024

The nasal cavity is a sporadic site for mesiodens, and if it is impacted in the lower nasal floor or localized in the nasal septum, it may cause various nasal symptoms such as nasal obstruction, recurrent rhinitis, and epistaxis. Early diagnosis is m...

  • Interesting Images
  • Open Access
1 Citations
3,836 Views
5 Pages

Febrile Rash: An Early Diagnostic Clue to Infectious Illness in Travelers Returning from Thailand

  • Hisham Ahmed Imad,
  • Anastasia Putri,
  • Ratchata Charoenwisedsil,
  • Sakarn Charoensakulchai and
  • Eric Caumes

The eruption of a rash along with spiking fever in travelers returning from the tropics may be suspicious of arboviral diseases, and isolation prevent further transmission in non-endemic countries. The case presented here was seen at the Fever Clinic...

  • Case Report
  • Open Access
1 Citations
3,082 Views
9 Pages

Tibial Periprosthetic fractures (PPF) after primary total knee arthroplasty (TKA) are uncommon and mainly occur after trauma. Various management options have been proposed; however, the decision mainly relies on the location of the fracture and the t...

  • Interesting Images
  • Open Access
1,339 Views
3 Pages

While insertion of a central venous catheter (CVC) for intravascular access, diagnosis, and intensive care medical treatment is frequently needed in critically ill patients, retention of the guidewire used for CVC placement with Seldinger’s tec...

  • Article
  • Open Access
2 Citations
3,091 Views
9 Pages

Drug–Drug Interactions of Hydroxychloroquine and Chloroquine in Older Patients with COVID-19 during the First Pandemic Waves: The GeroCovid Observational Study

  • Caterina Trevisan,
  • Andrea Cignarella,
  • Andrea Grandieri,
  • Giuseppe Sergi,
  • Stefano Fumagalli,
  • Fabio Monzani,
  • Chukwuma Okoye,
  • Giuseppe Bellelli,
  • Alba Malara and
  • The GeroCovid Acute Ward Working Group
  • + 3 authors

Objective: Chloroquine (CQ) and hydroxychloroquine (HCQ) were used as off-label treatments for SARS-CoV-2 infection during the first pandemic waves. The urgency of combatting COVID-19 led to the dissemination of medical recommendations with a scarce...

  • Article
  • Open Access
1 Citations
2,288 Views
12 Pages

Background: This study aimed to compare the clinical outcomes of using two different devices to treat upper palatal discrepancies evaluated with a digital intraoral scanner. Methods: A total of 64 patients were enrolled and treated with either an ela...

  • Case Report
  • Open Access
1 Citations
4,708 Views
9 Pages

Descending Necrotizing Mediastinitis in Healthy Young Adults: The Fatal Consequence of the Delayed Help

  • Petar Uchikov,
  • Maria Kraeva,
  • Krasimir Kraev,
  • Bozhidar Hristov,
  • Dzhevdet Chakarov,
  • Nedzhat Ali,
  • Chavdar Stefanov,
  • Angelina Mollova-Kyosebekirova,
  • Tihomir Tenchev and
  • Bistra Dobreva-Yatseva
  • + 2 authors

Introduction: Descending necrotizing mediastinitis is one of the most lethal forms of acute mediastinitis. It originates from an odontogenic or deep neck infection, which descends to the mediastinum through the fascial planes. It is a rare condition,...

  • Case Report
  • Open Access
1 Citations
2,907 Views
5 Pages

Management of Pregnancy in a Patient with Familial Hypercholesterolemia and Previous Myocardial Infarction—Treatment with LDL Apheresis: A Case Report

  • Milos Milincic,
  • Jovana Todorovic,
  • Stefan Dugalic,
  • Ivana Novakovic,
  • Maja Macura,
  • Katarina Lalic and
  • Miroslava Gojnic Dugalic

Familial hypercholesterolemia, a genetic disorder marked by elevated low-density lipoprotein cholesterol (LDL-C), poses significant risks for premature atherosclerosis and cardiovascular diseases, particularly during pregnancy. One of the safe method...

  • Case Report
  • Open Access
3,143 Views
10 Pages

Cost-Effectiveness in Alternative Treatment Options for Pancreatic Pseudocysts

  • Nikola Boyanov,
  • Nikol Milinich,
  • Katina Shtereva,
  • Katerina Madzharova,
  • Stoilka Tufkova,
  • Mariana Penkova-Radicheva,
  • Daniela Radicheva and
  • Neno Shopov

Background and Objectives: Pancreatic pseudocysts often arise as complications of pancreatitis and present unique challenges in clinical management, encompassing considerations for both technical aspects and financial implications. Before the advance...

  • Article
  • Open Access
2,701 Views
10 Pages

Trophoblast Cell Surface Antigen 2 (Trop2) Is Expressed in Cases of EBV-Positive Diffuse Large B-Cell Lymphoma Emerging from Angioimmunoblastic T-Cell Lymphoma

  • Susanne Ghandili,
  • Judith Dierlamm,
  • Carsten Bokemeyer,
  • Clara Marie von Bargen,
  • Anne Menz and
  • Sören Alexander Weidemann

Although trophoblast cell surface antigen 2 (Trop2)-targeting drugs are already approved or under investigation in various solid tumors, the significance of Trop2 in lymphoma is unknown. Thus, our objective was to investigate the expression of Trop2...

  • Case Report
  • Open Access
18,443 Views
5 Pages

Gardasil 4, a human papilloma virus vaccine, has been shown to protect against various cancers, including cervical cancer. Common side effects include injection site pain, fever, headaches, and muscle aches. In some individuals, the severe side effec...

  • Article
  • Open Access
1 Citations
1,848 Views
15 Pages

Development and Validation of the Bone Tumor Surgery Complexity Score

  • Annika Frei,
  • Georg Schelling,
  • Philip Heesen,
  • Pietro Giovanoli and
  • Bruno Fuchs

Bone tumors often manifest with non-specific symptoms such as pain and swelling, often posing diagnostic challenges. Optimal treatment requires centralized care in specialized centers, emphasizing the need for complete tumor removal and interdiscipli...

  • Case Report
  • Open Access
2,912 Views
7 Pages

Waldenstrom Macroglobulinemia Recurrence with Bing–Neel Syndrome Presentation

  • Raffaella Capasso,
  • Miriam Buonincontro,
  • Ferdinando Caranci and
  • Antonio Pinto

Bing–Neel syndrome (BNS) is a rare condition that may occur in patients with Waldenstrom macroglobulinemia (WM) and is caused by lymphoplasmacytic infiltration into the central nervous system. BNS is an extramedullary manifestation of WM which...

  • Case Report
  • Open Access
2 Citations
4,233 Views
7 Pages

Proton Pump Inhibitors Induced Hyponatremia in a Liver Transplanted Patient—The Role of Deprescribing: A Case Report and Literature Review

  • Gianmarco Marcianò,
  • Benedetto Caroleo,
  • Luca Catarisano,
  • Donatella Cocchis,
  • Caterina Palleria,
  • Giovambattista De Sarro and
  • Luca Gallelli

Liver transplant patients are frail subjects due to lifelong therapy with immunosuppressants. In these patients, comorbidity and polytherapy increase the risk of adverse drug reactions. In this study, we report the development of hyponatremia, probab...

  • Case Report
  • Open Access
1 Citations
3,300 Views
12 Pages

Leukocyte-Platelet-Rich Fibrin in Bone Regeneration after Periapical Surgery: A 30-Month Follow-Up Clinical Report

  • Hatim A. Qurban,
  • Hatem Hazzaa Hamadallah,
  • Mohammad A. Madkhaly,
  • Muhannad M. Hakeem and
  • Ahmed Yaseen Alqutaibi

26 April 2024

Aim and background: Periapical lesions, which occur due to the infection and necrosis of dental pulp, are a significant dental pathology that poses risks to oral and systemic health. These lesions often require interventions such as root canal treatm...

  • Article
  • Open Access
2 Citations
2,335 Views
8 Pages

26 April 2024

Background: Resistant bacteria causing urinary tract infections (UTI) are becoming increasingly common worldwide. Patients suffering from such UTIs are often elderly, with complex medical backgrounds, and require prolonged hospital stays due to the f...

  • Case Report
  • Open Access
3,127 Views
7 Pages

Complex Presentation of Lung Cancer with Obstructive Jaundice

  • Ruxandra Oprita,
  • Bogdan Oprita,
  • Ioana Adriana Serban,
  • Lidia Aurelia Stefan,
  • Ciprian Mihai Neacsu,
  • Alice Elena Diaconu and
  • Valentin Enache

24 April 2024

Background: Lung cancer, particularly small-cell lung carcinoma (SCLC), often presents with respiratory symptoms. However, atypical manifestations including jaundice and abdominal pain can obscure the diagnosis, leading to challenges in early detecti...

  • Case Report
  • Open Access
3 Citations
4,595 Views
7 Pages

The Resolution of Obstructive Sleep Apnea in a Patient with Goiter after Total Thyroidectomy: A Case Report

  • Yacine Ouahchi,
  • Maha Mejbri,
  • Azza Mediouni,
  • Abir Hedhli,
  • Ines Ouahchi,
  • Mounira El Euch,
  • Sonia Toujani and
  • Besma Dhahri

22 April 2024

Obstructive sleep apnea (OSA) may be linked to various factors that narrow the upper airways, such as obesity, adenotonsillar hypertrophy and craniofacial abnormalities. Hypothyroidism has also been described as a risk factor for OSA. However, the im...

  • Case Report
  • Open Access
3,998 Views
9 Pages

Atypical Teratoid/Rhabdoid Tumor with Retained SMARCB1 (INI1) Expression and Rare SMARCA4 Gene Mutation: A Case Report of a Pediatric Patient

  • Anna Marija Mališkina,
  • Ivanda Franckeviča,
  • Zelma Višņevska-Preciniece,
  • Marika Grūtupa and
  • Žanna Kovaļova

22 April 2024

Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive tumors of the central nervous system (CNS), accounting for 1–3% of all pediatric CNS tumors. In general, AT/RTs are associated with biallelic inactivation of SMARCB1, resulting in...

  • Case Report
  • Open Access
5,501 Views
5 Pages

18 April 2024

Facial nerve palsy is most commonly idiopathic, but it can also result from infections, inflammatory and cerebrovascular disorders, tumors, and trauma. We report the case of a 68-year-old patient who developed iatrogenic facial nerve palsy subsequent...

  • Brief Report
  • Open Access
1 Citations
2,952 Views
11 Pages

Pulmonologist-Performed Ultrasound-Guided Fine-Needle Aspiration of Lung Lesions

  • Chin-Tong Kwok,
  • Yiu-Cheong Yeung,
  • Yu-Hong Chan and
  • Man-Ying Ho

10 April 2024

Background and objective: Lung cancer is increasingly common, and accurate diagnosis is important for personalized treatment. Ultrasound-guided percutaneous fine-needle aspiration (FNA) is a useful method to obtain a specimen for a histological diagn...

  • Case Report
  • Open Access
1 Citations
2,785 Views
13 Pages

Wedge Resection and Optimal Solutions for Invasive Pulmonary Fungal Infection and Long COVID Syndrome—A Case Report and Brief Literature Review

  • Ioana-Madalina Mosteanu,
  • Beatrice Mahler,
  • Oana-Andreea Parliteanu,
  • Alexandru Stoichita,
  • Radu-Serban Matache,
  • Angela-Stefania Marghescu,
  • Petruta-Violeta Filip,
  • Eugen Mota,
  • Mihaela Ionela Vladu and
  • Maria Mota

5 April 2024

A rise in fungal infections has been observed worldwide among patients with extended hospital stays because of the severe infection caused by the new coronavirus pandemic. A 62-year-old female patient was admitted with a severe form of Coronavirus di...

  • Interesting Images
  • Open Access
1 Citations
3,484 Views
4 Pages

Amnion Rupture Sequence

  • Nicolae Gică,
  • Florina Mihaela Nedelea,
  • Livia Mihaela Apostol,
  • Anca Maria Panaitescu,
  • Iulia Huluță,
  • Ana Maria Vayna,
  • Radu Botezatu and
  • Nicoleta Gana

27 March 2024

The amnion rupture sequence is a rare condition occurring early in pregnancy, resulting in complex fetal anomalies by disrupting normal embryonic development. The prevalence of amnion rupture sequence is reported to be 1.16 in 10,000 live births. Thi...

  • Case Report
  • Open Access
1 Citations
2,991 Views
8 Pages

West Nile Virus Meningoencephalitis—A Consideration for Earlier Investigation

  • David Burns,
  • Zachary Vinton,
  • Min Kyung Chung and
  • Johnny Cheng

27 March 2024

West Nile Virus (WNV) is an arbovirus endemic to many countries and has caused over 56,000 cases, with 2776 deaths in the U.S. from 1999 to 2022. WNV occurs most often in the fall, typically affecting elderly populations in states like Nebraska and A...

  • Case Report
  • Open Access
1 Citations
3,569 Views
7 Pages

Influence of Blood Glycemia Levels in Refraction, Binocular Vision and Accommodation: A Case Report

  • Marc Argilés,
  • Jessica Sala-Oller,
  • Bernat Sunyer-Grau,
  • Cristina Rovira-Gay and
  • Luis Pérez-Mañá

23 March 2024

This case report provides us with insight on how blood glycemia affects refraction, vergence and accommodation in a single diabetic patient. A 21-year-old type I diabetic woman was the subject studied in this report. Refraction, near and far fusional...

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Reports - ISSN 2571-841X