Dermatopathology, Volume 10, Issue 4
2023 December - 3 articles
Cover Story: Dermatomyositis is an immune-mediated myopathy with cutaneous and systemic manifestations. The classic histopathological findings include vacuolar interface changes with mucin deposition and a predominantly lymphocytic infiltrate. Although eosinophils have traditionally been considered rare in skin biopsies of patients with autoimmune connective tissue diseases, recent studies suggest that tissue eosinophils may be more prevalent than previously thought. In this case report, we present a case of dermatomyositis characterized by intensely pruritic papules and plaques, where the presence of tissue eosinophils on histopathology initially posed a diagnostic challenge. This case highlights the importance of not relying solely on tissue eosinophilia as an exclusion criterion in diagnosing dermatomyositis. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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