Nanomaterials, Volume 13, Issue 17
2023 September-1 - 111 articles
Cover Story: A novel ophthalmic drug delivery system was developed utilizing center-radial large-pore mesoporous silica nanoparticles (LPMSNs) responsive to pH variations. LPMSNs effectively load ophthalmic drugs via hydrogen bonding and charge adsorption at a pH below 6.5, and subsequently release them in the physiological environment (pH 7.4) via diffusion and desorption processes. This pH-sensitive property, combined with LPMSNs' ability to enhance drug loading efficiency and provide sustained drug release, underscores their significant applicative potential in emerging biomedical applications. This innovative technology holds great promise for targeted drug delivery, personalized medicine and the treatment of various diseases. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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