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Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates
1
Institute for Organic Chemistry, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany
2
Institute for Inorganic and Analytical Chemistry, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(11), 2432; https://doi.org/10.3390/molecules29112432
Submission received: 24 April 2024
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Revised: 15 May 2024
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Accepted: 20 May 2024
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Published: 21 May 2024
(This article belongs to the Section Organic Chemistry)
Abstract
A microwave-assisted synthesis of dialkyl and cyclic H-phosphonates via bis(2,2,2 trifluoroethyl) phosphonate (BTFEP) is described. This method enables the synthesis of various cyclic H-phosphonates and hetero-substituted dialkyl H-phosphonates by simple alcoholysis under non-inert and additive-free conditions. Short reaction times and the requirement for only stoichiometric amounts of alcohol render this method attractive for synthetic applications.
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MDPI and ACS Style
Pohl, J.-M.; Stöhr, F.; Kramer, T.; Becker, J.; Göttlich, R. Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates. Molecules 2024, 29, 2432. https://doi.org/10.3390/molecules29112432
AMA Style
Pohl J-M, Stöhr F, Kramer T, Becker J, Göttlich R. Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates. Molecules. 2024; 29(11):2432. https://doi.org/10.3390/molecules29112432
Chicago/Turabian StylePohl, Jean-Marie, Fabian Stöhr, Tim Kramer, Jonathan Becker, and Richard Göttlich. 2024. "Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates" Molecules 29, no. 11: 2432. https://doi.org/10.3390/molecules29112432
