Search Results (111)

Background and Objectives: The management of type 2 diabetes (T2D) extends beyond glycemic control, requiring a more global strategy that includes optimization of body composition, even more so in the context of sarcopenia and visceral adiposity, as they contribute to poor outcomes. Past reviews have typically been focused on weight reduction or glycemic effectiveness, with limited inclusion of new therapies’ effects on muscle and fat distribution. In addition, the emergence of incretin-based therapies and dual agonists such as tirzepatide requires an updated synthesis of their impacts on body composition. This review attempts to bridge the gap by taking a systematic approach to how current blood-glucose lowering therapies affect lean body mass, fat mass, and the risk of sarcopenia in T2D patients. Materials and Methods: Between January 2015 and March 2025, we conducted a narrative review by searching the PubMed, Scopus, and Web of Science databases for English-language articles. The keywords were combinations of the following: “type 2 diabetes,” “lean body mass,” “fat mass,” “body composition,” “sarcopenia,” “GLP-1 receptor agonists,” “SGLT2 inhibitors,” “tirzepatide,” and “antidiabetic pharmacotherapy.” Reference lists were searched manually as well. The highest precedence was assigned to studies that aimed at adult type 2 diabetic subjects and reported body composition results. Inclusion criteria for studies were: (1) type 2 diabetic mellitus adult patients and (2) reporting measures of body composition (e.g., lean body mass, fat mass, or muscle function). We prioritized randomized controlled trials and large observational studies and excluded mixed diabetic populations, non-pharmacological interventions only, and poor reporting of body composition. Results: Metformin was widely found to be weight-neutral with minimal effects on muscle mass. Insulin therapy, being an anabolic hormone, often leads to fat mass accumulation and increases the risk of sarcopenic obesity. Incretin-based therapies induced substantial weight loss, mostly from fat mass. Notable results were observed in studies with tirzepatide, demonstrating superior reduction not only in fat mass, but also in visceral fat. Sodium-glucose cotransporter 2 inhibitors (SGLT2 inhibitors) promote fat loss but are associated with a small yet significant decrease in lean muscle mass. Conclusions: Blood-glucose lowering therapies demonstrated clinically relevant effects on body composition. Treatment should be personalized, balancing glycemic control, cardiovascular, and renal benefits, together with optimal impact on muscle mass along with glycemic, cardiovascular, and renal benefits. Full article

Malignant mediastinal tumors are a group representing some of the most demanding oncological challenges for early, multi-level, and successful management. The timely identification of any suspicious clinical symptomatology is urgent in achieving an accurate, staged histological diagnosis, in order to follow up with an equally detailed medical therapeutic plan (interventional or not) and determine the principal goals regarding efficient overall treatment in these patients. We report a case of a 24-year-old male patient with an incident-free prior medical history. An initial chest X-ray was performed after the patient reported short-term, consistent moderate chest pain symptomatology, early work fatigue, and shortness of breath. The following imaging procedures (chest CT, PET-CT) indicated the presence of an anterior mediastinal mass (meas. ~11 cm × 10 cm × 13 cm, SUV: 8.7), applying additional pressure upon both right heart chambers. The Alpha-Fetoprotein (aFP) blood levels had exceeded at least 50 times their normal range. Two consecutive diagnostic attempts with non-specific histological results, a negative-for-malignancy fine-needle aspiration biopsy (FNA-biopsy), and an additional tumor biopsy, performed via mini anterior (R) thoracotomy with “suspicious” cellular gatherings, were performed elsewhere. After admission to our department, an (R) Video-Assisted Thoracic Surgery (VATS) was performed, along with multiple tumor biopsies and moderate pleural effusion drainage. The tumor’s measurements had increased to DMax: 16 cm × 9 cm × 13 cm, with a severe degree of atelectasis of the Right Lower Lobe parenchyma (RLL) and a pressure-displacement effect upon the Superior Vena Cava (SVC) and the (R) heart sinus, based on data from the preoperative chest MRA. The histological report indicated elements of a combined, non-seminomatous germ-cell mediastinal tumor, posthuberal-type teratoma, and embryonal carcinoma. The imminent chemotherapeutic plan included a “BEP” (Bleomycin^®/Cisplatin^®/Etoposide^®) scheme, which needed to be modified to a “VIP” (Cisplatin^®/Etoposide^®/Ifosfamide^®) scheme, due to an acute pulmonary embolism incident. While the aFP blood levels declined, even reaching normal measurements, the tumor’s size continued to increase significantly (DMax: 28 cm × 25 cm × 13 cm), with severe localized pressure effects, rapid weight loss, and a progressively worsening clinical status. Thus, an emergency surgical intervention took place via median sternotomy, extended with a complementary “T-Shaped” mini anterior (R) thoracotomy. A large, approx. 4 Kg mediastinal tumor was extracted, with additional RML and RUL “en-bloc” segmentectomy and partial mediastinal pleura decortication. The following histological results, apart from verifying the already-known posthuberal-type teratoma, indicated additional scattered small lesions of combined high-grade rabdomyosarcoma, chondrosarcoma, and osteosarcoma, as well as numerous high-grade glioblastoma cellular gatherings. No visible findings of the previously discovered non-seminomatous germ-cell and embryonal carcinoma elements were found. The patient’s postoperative status progressively improved, allowing therapeutic management to continue with six “TIP” (Cisplatin^®/Paclitaxel^®/Ifosfamide^®) sessions, currently under his regular “follow-up” from the oncological team. This report underlines the importance of early, accurate histological identification, combined with any necessary surgical intervention, diagnostic or therapeutic, as well as the appliance of any subsequent multimodality management plan. The diversity of mediastinal tumors, especially for young patients, leaves no place for complacency. Such rare examples may manifest, with equivalent, unpredictable evolution, obliging clinical physicians to stay constantly alert and not take anything for granted. Full article

Overfitting remains a major difficulty in training deep neural networks, especially when attempting to achieve good generalization in complex classification tasks. Standard dropout is often employed to address this issue; however, its uniform random inactivation of neurons typically leads to instability and insufficient performance increases. This paper proposes an upgraded regularization technique merging adaptive sigmoidal dropout with weight amplification, seeking to dynamically adjust neuron deactivation depending on weight statistics, activation patterns, and neuron history. The proposed dropout process uses a sigmoid function driven by a temperature parameter to determine deactivation likelihood and incorporates a “neuron recovery” step to restore important activations. Simultaneously, the method amplifies high-magnitude weights to select crucial traits during learning. The proposed method is tested on CIFAR-10, and CIFAR-100 datasets using four unique CNN architectures, including deep and residual-based models, to evaluate the approach. Results demonstrate that the suggested technique consistently outperforms both standard dropout and baseline models without dropout, yielding higher validation accuracy and lower, more stable validation loss across all datasets. In particular, it demonstrated superior convergence and generalization performance on challenging datasets such as CIFAR-100. These findings demonstrate the potential of the proposed technique to improve model robustness and training efficiency and provide an alternative in complex classification tasks. Full article

Background/Objectives: Obesity among university students is a growing concern, often influenced by biological, psychological, and social factors. Few studies in Saudi Arabia have addressed this issue using a comprehensive framework. This study aims to examine the prevalence of obesity and its biopsychosocial predictors among university students, as well as their perceptions, behaviors, and comorbidities. Methods: A cross-sectional study was conducted at Jazan University during the 2024–2025 academic year. A total of 819 undergraduate students completed a structured, self-administered Arabic questionnaire. The tool assessed sociodemographic variables, body mass index (BMI) (calculated from self-reported height and weight), biological and psychological factors, social influences, lifestyle behaviors, and comorbidities. Bivariate associations were tested using chi-square analyses, and multivariate logistic regression was used to identify independent predictors of obesity. Results: The prevalence of obesity was 19.6%, and 22.6% of students were overweight. Obesity was significantly more prevalent among males (26.7%) than females (9.6%, p < 0.001) and among students aged 24 years and above (24.0%, p = 0.024). Independent predictors of obesity included being overweight in childhood (AOR = 5.23, 95% CI: 3.47–7.90), belief in a genetic predisposition (AOR = 4.66), emotional eating (AOR = 2.57), academic or personal stress (AOR = 5.36), and social pressures related to body image (AOR = 2.96). Comorbidities significantly associated with obesity included high cholesterol (AOR = 5.40), sleep disorders (AOR = 2.99), and joint pain (AOR = 1.96). More than 80% of students with obesity reported current or past weight loss attempts, and nearly 60% received medical advice to lose weight. Conclusions: Obesity among Jazan University students is significantly associated with male gender, early-life weight history, emotional and academic stress, and social pressures. Students with obesity also experience a higher burden of comorbid conditions, even at a young age. These findings highlight the need for integrated, student-centered interventions that address both the psychological and social dimensions of weight management in university settings. Full article

Background/Objectives: Weight loss and its subsequent regain pose significant challenges for those dealing with overweight and obesity. This study explores weight loss strategies among adults in Saudi Arabia and evaluates factors linked to weight regain. Methods: This cross-sectional study focused on adults residing in Jazan, located in southwest Saudi Arabia. Data collection was conducted using a self-administered questionnaire that assessed participants’ demographics, medical history, perceptions of body weight, weight loss methods, and the incidence of weight regain. Logistic regression was used to determine whether there were statistically significant differences related to the occurrence of weight regain. Results: A total of 368 participants reported efforts to lose weight over the past 3 years. The average age of these participants was 32.7 years (standard deviation: 11.3), and the gender distribution was almost equal. The majority of the sample (65%) voiced dissatisfaction with their body weight. Some participants employed a combination of weight loss methods, with exercise, reduced food intake, and intermittent fasting being the most frequently mentioned. The findings also indicate that a minority sought professional help, whether from a physician or a nutritionist. Over 90% claimed to have successfully lost weight at least once during their attempts, but more than half (139 individuals) experienced weight regain following their weight loss efforts. Within the univariate logistic regression, higher odds ratios of weight regain were detected among men, older participants, those living in rural areas, individuals with higher levels of education, employed persons or business owners, those with higher monthly incomes, smokers, khat chewers, and those diagnosed with a chronic condition (p values < 0.05). However, the multivariate logistic regression revealed that only residence, monthly income, smoking status, and being diagnosed with a chronic disease remained statistically significant as predictors of weight regain after adjusting for other variables (p values < 0.05). Conclusions: These findings highlight the significance of incorporating weight regain prevention into body weight management for individuals dealing with overweight and obesity. Further research is needed to evaluate specific dietary, physical activity, and psychological factors that may increase the risk of weight regain in certain participants. Full article

Tear film alterations are commonly associated with ocular pathology. The tear film plays a vital role in maintaining the optical properties of the cornea and contains essential elements required for healing and preserving the integrity of the ocular surface. As a biological fluid, the tear film is easily collected using non-invasive techniques, making it a promising candidate for analysis and often referred to as an ideal biofluid. Several studies have attempted to identify biomarkers in the tear film that could be linked to systemic or ocular disorders, with the goal of developing tools for diagnosis or even early prevention. The quality and quantity of the tear film are influenced by hormonal status, emotional experiences related to social and familial events, and the work environment. Systemic disorders are often reflected at the ocular level through alterations in the tear film. Obesity is a well-recognized public health concern, extensively studied and investigated, much like other common systemic conditions. The presence of low-grade, chronic inflammation associated with excess body weight has been validated in several studies. The strategies for preventing obesity induced dry eye disease are based on regular physical activity, maintaining adequate hydration through sufficient fluid intake, weight loss, and the supplementation of essential fatty acids. This narrative literature review aims to highlight the tear film alterations associated with obesity. The article is intended for ophthalmologists, general practitioners, nutritionists, and researchers. Full article

Background and Objectives: The associations between body appreciation, weight status, and weight management practices are influenced by societal, cultural, and psychological factors. Studies indicated that a higher level of body appreciation is linked to lower engagement in unhealthy weight management practices. The transition from high school to university is a significant life event, often accompanied by substantial lifestyle changes that can affect students’ body image and weight-related behaviours. This study aimed to assess the associations between body appreciation, weight status, and weight management behaviours among first-year students at four universities of applied sciences in Lithuania. Materials and Methods: A cross-sectional online survey was conducted in 2022 among 709 first-year students (216 males and 493 females) at the four largest universities of applied sciences in Vilnius, Kaunas, Klaipėda, and Šiauliai. Body appreciation was assessed using the Body Appreciation Scale-2 (BAS-2), whilst BMI was calculated from self-reported height and weight. Students were asked about their weight management practices. Logistic regression analysis was applied to evaluate associations between weight management behaviours, body appreciation, and weight status. Results: Female students had a significantly lower median BMI (21.1 kg/m²) than males (23.3 kg/m²) but were more likely to perceive themselves as overweight (34.5% vs. 17.1%), worry about gaining weight (40.6% vs. 11.6%), and attempt weight loss (52.5% vs. 23.6%) (all p < 0.001). Higher BAS scores were associated with greater accuracy in weight perception, higher satisfaction with body weight, and fewer concerns about weight gain. Students with lower BAS scores were more likely to engage in harmful weight-control behaviours such as smoking (OR = 0.07; 95% CI: 0.02–0.25 for high vs. low BAS) and were more strongly influenced by media beauty standards and dissatisfaction with appearance. Conclusions: Body appreciation is linked to healthier weight perceptions and behaviours. Interventions that enhance body appreciation may help reduce body dissatisfaction and prevent unhealthy weight control practices, especially among female students. Full article

Due to the intermittent and uncertain nature of emerging renewable energy sources in the modern power grid, the level of dispatchable power sources has been reduced. The contemporary power system is attempting to address this by investing in energy storage within the context of standalone microgrids (SMGs), which can operate in an island mode and off-grid. While renewable-rich SMGs can facilitate a higher level of renewable energy penetration, they also have more reliability issues compared to conventional power systems due to the intermittency of renewables. When an SMG system needs to be upgraded for reliability improvement, the cost of that reliability improvement should be divided among diverse customer sectors. In this research, we present four distinct approaches along with comprehensive simulation outcomes to address the problem of allocating reliability costs. The central issue in this study revolves around determining whether all consumers should bear an equal share of the reliability improvement costs or if these expenses should be distributed among them differently. When an SMG system requires an upgrade to enhance its reliability, it becomes imperative to allocate the associated costs among various customer sectors as equitably as possible. In our investigation, we model an SMG through a simulation experiment, involving nine distinct customer sectors, and utilize their hourly demand profiles for an entire year. We explore how to distribute the total investment cost of reliability improvement to each customer sector using four distinct methods. The first two methods consider the annual and seasonal peak demands in each industry. The third approach involves an analysis of Loss of Load (LOL) events and determining the hourly load requirements for each sector during these events. In the fourth approach, we employ the Technique for Order of Preference by Similarity to the Ideal Solution (TOPSIS) technique. The annual peak demand approach resulted in the educational sector bearing the highest proportion of the reliability improvement cost, accounting for 21.90% of the total burden. Similarly, the seasonal peak demand approach identified the educational sector as the most significant contributor, though with a reduced share of 15.44%. The normalized average demand during Loss of Load (LOL) events also indicated the same sector as the highest contributor, with 12.34% of the total cost. Lastly, the TOPSIS-based approach assigned a 15.24% reliability cost burden to the educational sector. Although all four approaches consistently identify the educational sector as the most critical in terms of its impact on system reliability, they yield different cost allocations due to variations in the methodology and weighting of demand characteristics. The underlying reasons for these differences, along with the practical implications and applicability of each method, are comprehensively discussed in this research paper. Based on our case study findings, we conclude that the education sector, which contributes more to LOL events, should bear the highest amount of the Cost of Reliability Improvement (CRI), while the hotel and catering sector’s share should be the lowest percentage. This highlights the necessity for varying reliability improvement costs for different consumer sectors. Full article

Context: Intermittent fasting (IF) and calorie restriction (CR) have gained interest as dietary strategies due to their potential for weight loss and multiple metabolic benefits. These strategies are often accompanied by exercise in an attempt to improve body composition and physical performance. However, further research is crucial to understanding whether or not physical performance is affected by the expected weight loss and related body composition changes in individuals on IF and CR, even when exercise is combined. Objective: We aimed to systematically evaluate the effects of IF and CR on exercise performance and body composition in adults aged 18 to 65 years. Data Source: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A systematic review was conducted up to April 2024 by searching electronic databases, including PubMed, Web of Science, and Scopus. There was no limit on publication dates. Data Extraction: The search explored the impact of IF and CR combined with exercise vs. exercise alone (control) on exercise performance outcomes: VO_2max, handgrip strength, bench press strength, knee extensor strength, leg press strength, countermovement jump (CMJ), 400 m walk test, and gait speed; body weight, body mass index (BMI), and body composition: fat-free mass (FFM), fat mass (FM), and body fat percentage (BFP). Analyses included calculation of weighted mean difference (WMD), standardized mean difference (SMD), and 95% confidence intervals (CIs) to assess outcomes. Data Analysis: The meta-analysis included a total of 35 studies, ranging from 4 to 52 weeks and involving 1266 participants. The results showed that IF (hypocaloric or eucaloric diet) and CR combined with exercise increased handgrip strength [WMD = 1.707 kg, p = 0.01] compared to exercise alone. Moreover, IF and CR combined with exercise did not significantly affect VO_2max [SMD = 0.005, p = 0.94], bench press strength [WMD = 0.377 kg, p = 0.778], knee extensor strength [WMD = −4.729 kg, p = 0.12], leg press strength [WMD = −2.874 kg, p = 0.415], countermovement jump [WMD = −0.226 cm, p = 0.80], 400 m walk test performance [WMD = −8.794 s, p = 0.06], or gait speed [WMD = 0.005 m/s, p = 0.82] compared to exercise alone. Moreover, IF and CR combined with exercise decreased body weight [WMD = −4.375 kg, p = 0.001], BMI [WMD = −1.194 kg·m⁻², p = 0.001], FFM [WMD = −1.653 kg, p = 0.001], FM [WMD = −2.858 kg, p = 0.001], BFP [WMD = −0.826%, p = 0.001] compared to exercise alone. Conclusions: IF (hypocaloric or eucaloric) and CR can be effectively integrated into exercise training without negatively impacting most measures of physical performance, while significantly enhancing weight loss and adiposity-related outcomes. The findings from this meta-analysis involving both athletes and non-athletes suggest that weight loss induced by IF and CR combined with exercise does not necessarily result in reduced physical performance. In real-world scenarios, however, different outcomes are conceivable, as body composition, physical capacity, diet and exercise can vary considerably based on individual conditions. Full article

Deep coalbed methane (CBM) is rich in resources and is an important replacement resource for tight gas in China. Accurate prediction of post-fracture production and dynamic change characteristics of fractured wells of partial CBM is of great significance in predicting the final recovery rate. In terms of predicting time-series production, the problem one encounters is low prediction accuracy and poor generalisation ability under limited sample conditions. In this paper, we propose a hybrid deep neural network (AT-GRU-MTL) production prediction model based on the combination of an attention mechanism gated recurrent neural network (GRU) and multi-task learning (MTL), where the AT-GRU is responsible for capturing the nonlinear pattern of the production change, while introducing an MTL method that includes a cross-stitch network (CSN) and a weighted loss using homoskedasticity uncertainty to automatically determine the degree of sharing between multiple tasks and the weighting ratio of the total loss function. The model is applied to several typical deep CBM fracturing wells in China, and the accuracy of gas production prediction reaches 90%, while the accuracy of water production prediction is 68%. The experimental results show that, for the blocks with a very large difference in the order of magnitude of the gas and water production, it is very easy for a certain small order of magnitude to be suppressed from learning during the two-way multi-task learning process, which leads to deterioration of its prediction effect; at the same time, the adaptability of the model is evaluated, and it is found that the model is more advantageous for the wells that have been produced for approximately one year. Meanwhile, the evaluation of the model adaptability shows that the model is more dominant in the prediction of wells with production of about one and a half years. Based on the two test wells with shorter (380 days) and longer (709 days) spans, the results indicate that the model may have insufficient sensitivity to the sudden change of the ratio of gas to water and the failure of the dynamic generalisation of the matrix shrinkage–desorption coupling, and the introduction of physical constraints (such as bottomhole flow pressure, etc.) or the division of the data into the production stages may be attempted to deal with the case subsequently. The research results in this paper provide a theoretical basis for dynamic production prediction and analysis in oil and gas field sites. Full article

Aluminum foam is expected to be a leading candidate for lightweight parts due to its light weight and excellent shock-absorption and sound-absorption properties. In order to use it as a part, it is essential to form it into the desired shape. However, the cell walls that form the pores are composed of thin aluminum. When aluminum foam is formed, the cell walls easily fracture and the pores collapse. This results in the loss of the properties of the aluminum foam. Past studies have shown that press forming aluminum foam immediately after foaming, while it is still in the softened state, prevents cell wall failure and pore deformation. In this study, we attempted to perform a continuous process from the foaming of the precursor to the press forming of aluminum foam for three precursors, for the purpose of the continuous production of aluminum foam with desired shapes. It was shown that it is possible to continuously and sequentially foam the precursors by heating and press forming the foamed samples. In addition, aluminum foam with a similar shape, porosity, and pore structure can be fabricated using the continuous process. Also, it was shown that aluminum foam with complex shapes can also be continuously fabricated by using a complex-shaped die. Furthermore, it was indicated that the use of a die in press forming can shorten the cooling time and reduce the production time. Full article

Introduction: Obesity is associated with cardiometabolic diseases, and chrononutrition has become a novel weight loss strategy. However, few have characterized chrononutrition patterns among people attempting weight loss. This study characterizes chrononutrition patterns in a nationally representative sample of U.S. adults who attempted weight loss in the past year through dietary modifications by weight change and adiposity. Methods: This cross-sectional analysis utilizes NHANES 2017–2020 data. Chrononutrition patterns were assessed using 24 h dietary recalls. Participants self-reported weight loss attempts in the past year and if they tried using diet modification. Weight change (loss, maintenance, and gain) was defined based on differences in current weight and weight one year prior. We used latent profile analysis and descriptive statistics. Results: The sample included 2107 participants who attempted weight loss in the past year through diet modification (median age 47; 58% women and 62% white). Individuals who gained weight (vs. loss) had longer hours between waketime and the first eating (1.78 vs. 1.62 h, p = 0.024), consumed a lower proportion of calories later in the day (43% vs. 52%, p < 0.001), and ate less frequently (5.20 vs. 5.43 episodes, p = 0.008). Participants with obesity had the shortest eating window (11.77 vs. 12.22 h, p = 0.02) despite a longer delay between waketime and the first eating (1.80 vs. 1.29 h, p < 0.001) and lower eating frequency (5.16 vs. 5.97, p < 0.001). Conclusions: Variations in eating timing, eating episodes, and caloric distribution suggest that chrononutrition may play a role in personalized weight management strategies. Full article

Three-dimensional ocean observation is the foundation for accurately predicting ocean information. Although ocean observation sensor arrays can obtain internal data, their deployment is difficult, costly, and prone to component failures and environmental noise, resulting in discontinuous data. To address the severe missing data problem in three-dimensional ocean flow fields, this paper proposes an unsupervised model: Three-dimensional Spatio-Temporal Slim Weighted Generative Adversarial Imputation Network (3D-STA-SWGAIN). This method integrates spatio-temporal attention mechanisms and Wasserstein constraints. The generator captures the three-dimensional spatial distribution and vertical profile dynamic patterns through the spatio-temporal attention module, while the discriminator introduces gradient penalty constraints to prevent gradient vanishing. The generator strives to generate data that conforms to the real ocean flow field, and the discriminator attempts to identify pseudo-ocean current data samples. Through the adversarial training of the generator and the discriminator, high-quality completed data are generated. Additionally, a spatio-temporal continuity loss function is designed to ensure the physical rationality of the data. Experiments show that on the three-dimensional flow field dataset of the South China Sea, compared with methods such as GAIN, under a 50% random missing rate, this method reduces the error by 37.2%. It effectively solves the problem that traditional interpolation methods have difficulty handling non-uniform missing and spatio-temporal correlations and maintains the spatio-temporal continuity of the current field’s three-dimensional structure. Full article

The present study attempted to investigate the best conditions to use 2-(4-chlorophenyle)-1,4,5-triphenyle-H-imidazole as a corrosion inhibitor of mild steel in a 7% HCl and 20% H₂SO₄ pickling bath mixture, using chemical, electrochemical, and surface response methodologies in a spherical field. For this, a Doehlert matrix and two principal factors of the Pickling Process were examined. An experimental evaluation was carried out using weight loss, electrochemical impedance spectroscopy, and polarization curve measurements. Impedance diagrams and Bode plots for uninhibited and inhibited systems were analyzed and simulated using the Z-view program, the fitted data obtained closely followed the same pattern as the experimental results. This study demonstrates that the 2-(4-chlorophenyle)-1,4,5-triphenyle-H-imidazole compound is an effective inhibitor for mild steel in pickling bath solutions, and corrosion inhibition efficiency increases with increases in inhibitor concentration to attain 93.2% imidazole at 10⁻³ M. This is due to the absorbability of Cl⁻ and SO₄²⁻ present in the pickling bath solution and the synergistic effect between both elements. The response used in the exploitation of the design was the determination of inhibitor efficiency. This was assessed through weight loss measurements and electrochemical studies on samples in the absence and presence of 2-(4-chlorophenyle)-1,4,5-triphenyle-H-imidazole. It has been shown that the compound under investigation is an effective cathodic-type inhibitor of mild steel corrosion in pickling bath mixtures. Therefore, the inhibition efficiency was improved with the concentration of the inhibitor, which depended on the molecular structure. The optimal corrosion inhibition efficiency as a function of variation in 2-(4-chlorophenyle)-1,4,5-triphenyle-H-imidazole concentration and pickling bath temperature was simulated and demonstrated using canonical analysis; the obtained efficiency at 324 K for 6 h was 81.3% for the coded variable and 83.4% for the real variable. The experimental results are based on a real-time system and provide much more precise results than the simulated results. Full article

Objective: Our objective was to evaluate the association between ultra-processed food (UPF) consumption and body weight change after participating in nutritional intervention. Design: Our study was a 12-month follow-up of participants in a randomized controlled community trial. Setting: Brazilian Primary Health Care. Participants: The participants were health promotion services users. Users in the control group (CG) performed the service’s usual intervention, while those in the intervention group (IG) additionally participated for seven months in nutritional intervention. Socioeconomic data, self-health, perception of time spent in health promotion services, and weight loss attempts were investigated. Food consumption was obtained by 24 h food recall and categorizing these in quartiles according to the Nova system of food classification. Weight was measured and changes in the 12-month period were calculated by subtracting the weight at follow-up from the baseline measurement. Results: Of the participants, 88.1% were females aged 56.7 ± 11.8 with 19.7 ± 15.3 months of participation in the service. In the fourth quartile (highest UPF consumption), the % contribution of calories per consumption of UPFs was 47.7%, with no differences between the IG and CG (p = 0.406). Adjusted after 12 months, when comparing those with lower consumption of UPFs (first quartile), individuals from the second, third, and fourth quartiles had positive weight variation. Respectively, these variations were as follows: 0.363 kg (95% CI: 0.038; 0.689; p = 0.029); 0.467 kg (95% CI: 0.159; 0.776; p = 0.003); and 0.389 kg (95% CI: 0.061; 0.717; p = 0.020, with no differences between IG and CG). Conclusions: The percentage contribution of calories from UPFs was associated with positive weight change, which contributes to the growing evidence of the relationship between UPFs and obesity. Full article