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25 Results Found

  • Article
  • Open Access
418 Views
21 Pages

A Record–Replay-Based State Recovery Approach for Variants in an MVX System

  • Xu Zhong,
  • Xinjian Zhao,
  • Bo Zhang,
  • June Li,
  • Yifan Wang and
  • Yu Li

24 September 2025

Multi-variant execution (MVX) is an active defense technique that can detect unknown attacks by comparing the outputs of redundant program variants. Despite notable progress in MVX techniques in recent years, current approaches for recovery of abnorm...

  • Review
  • Open Access
913 Views
26 Pages

mRNA Isoforms and Variants in Health and Disease

  • Sharmin Shila,
  • Vinesh Dahiya,
  • Charles Hisle,
  • Elizabeth Bahadursingh,
  • Ramkumar Thiyagarajan,
  • Patrick E. Fields and
  • M. A. Karim Rumi

25 September 2025

Cellular gene expression varies in different physiological or pathological conditions. Conventional gene expression analysis assumes that each gene produces a single mRNA, which is not accurate. On average, genes express more than three mRNA isoforms...

  • Article
  • Open Access
7 Citations
2,982 Views
29 Pages

Color Image Self-Recovery and Tampering Detection Scheme Based on Fragile Watermarking with High Recovery Capability

  • Rogelio Reyes-Reyes,
  • Clara Cruz-Ramos,
  • Volodymyr Ponomaryov,
  • Beatriz P. Garcia-Salgado and
  • Javier Molina-Garcia

2 April 2021

In this paper, a fragile watermarking scheme for color image authentication and self-recovery with high tampering rates is proposed. The original image is sub-sampled and divided into non-overlapping blocks, where a watermark used for recovery purpos...

  • Article
  • Open Access
6 Citations
3,465 Views
30 Pages

The Simeck family of lightweight block ciphers was proposed by Yang et al. in 2015, which combines the design features of the NSA-designed block ciphers Simon and Speck. Previously, we proposed the use of linear cryptanalysis using super-rounds to in...

  • Article
  • Open Access
2 Citations
5,548 Views
34 Pages

We present attacks on 21-rounds of Simon 32/64, 21-rounds of Simon 48/96, 25-rounds of Simon 64/128, 35-rounds of Simon 96/144 and 43-rounds of Simon 128/256, often with direct recovery of the full master key without repeating the attack over multipl...

  • Article
  • Open Access
1 Citations
2,208 Views
17 Pages

16 December 2022

Rubber-like materials exhibit stress softening when subject to loading–unloading cycles, i.e., the Mullins effect. However, this phenomenon can be recovered after annealing the previously stretched sample under a stress-free state. The aim of t...

  • Article
  • Open Access
2 Citations
10,019 Views
21 Pages

Mineralogical Characteristics of Hematitic Iron Ore: A Geometallurgical Study on Ore from Eastern India

  • Chita R. Mahanta,
  • Prabodha R. Sahoo,
  • Manoj K. Mohanta,
  • Rajendra K. Rath,
  • Shobhana Dey,
  • Sunil Kumar Tripathy,
  • Jitendra Prasad and
  • Akella S. Venkatesh

12 September 2023

After being subjected to geometallurgical evaluation, the iron ores from Singhbhum Bonai-Keonjhar region, eastern India, have been designated as dense martite microplaty hematite high-strength ore (dM-mH-hs ore), massive dense martite microplaty hema...

  • Article
  • Open Access
17 Citations
4,803 Views
14 Pages

25 March 2019

Metastatic cancer cells are known to have a smaller cell stiffness than healthy cells because the small stiffness is beneficial for passing through the extracellular matrix when the cancer cells instigate a metastatic process. Here we developed a sim...

  • Article
  • Open Access
10 Citations
9,370 Views
17 Pages

A Preclinical Study on Brugada Syndrome with a CACNB2 Variant Using Human Cardiomyocytes from Induced Pluripotent Stem Cells

  • Rujia Zhong,
  • Theresa Schimanski,
  • Feng Zhang,
  • Huan Lan,
  • Alyssa Hohn,
  • Qiang Xu,
  • Mengying Huang,
  • Zhenxing Liao,
  • Lin Qiao and
  • Zhen Yang
  • + 20 authors

Aims: Some gene variants in the sodium channels, as well as calcium channels, have been associated with Brugada syndrome (BrS). However, the investigation of the human cellular phenotype and the use of drugs for BrS in presence of variant in the calc...

  • Review
  • Open Access
14 Citations
9,647 Views
40 Pages

29 August 2022

Optic neuritis (ON) is an inflammatory condition involving the optic nerve. Several important typical and atypical ON variants are now recognized. Typical ON has a more favorable prognosis; it can be idiopathic or represent an early manifestation of...

  • Article
  • Open Access
724 Views
15 Pages

Influence of Alpha/Gamma-Stabilizing Elements on the Hot Deformation Behaviour of Ferritic Stainless Steel

  • Andrés Núñez,
  • Irene Collado,
  • Marta Muratori,
  • Andrés Ruiz,
  • Juan F. Almagro and
  • David L. Sales

This study investigates the hot deformation behaviour and microstructural evolution of two AISI 430 ferritic stainless steel variants: 0A (basic) and 1C (modified). These variants primarily differ in chemical composition, with 0A containing higher au...

  • Article
  • Open Access
1,119 Views
17 Pages

Charge Reversal of the Uppermost Arginine in Sliding Helix S4-I Affects Gating of Cardiac Sodium Channel

  • Olga E. Kulichik,
  • Anastasia K. Zaytseva,
  • Anna A. Kostareva and
  • Boris S. Zhorov

Several mutations of the uppermost arginine, R219, in the voltage-sensing sliding helix S4I of cardiac sodium channel Nav1.5 are reported in the ClinVar databases, but the clinical significance of the respective variants is unknown (VUSs). AlphaFold...

  • Article
  • Open Access
8 Citations
3,085 Views
26 Pages

Model-Based Analysis of SARS-CoV-2 Infections, Hospitalization and Outcome in Germany, the Federal States and Districts

  • Christiane Dings,
  • Katharina Martha Götz,
  • Katharina Och,
  • Iryna Sihinevich,
  • Quirin Werthner,
  • Sigrun Smola,
  • Marc Bliem,
  • Felix Mahfoud,
  • Thomas Volk and
  • Sascha Kreuer
  • + 3 authors

24 September 2022

The coronavirus disease 2019 (COVID-19) pandemic challenged many national health care systems, with hospitals reaching capacity limits of intensive care units (ICU). Thus, the estimation of acute local burden of ICUs is critical for appropriate manag...

  • Review
  • Open Access
20 Citations
4,895 Views
23 Pages

Characterization and Quantification of Selenoprotein P: Challenges to Mass Spectrometry

  • Jérémy Lamarche,
  • Luisa Ronga,
  • Joanna Szpunar and
  • Ryszard Lobinski

Selenoprotein P (SELENOP) is an emerging marker of the nutritional status of selenium and of various diseases, however, its chemical characteristics still need to be investigated and methods for its accurate quantitation improved. SELENOP is unique a...

  • Article
  • Open Access
8 Citations
3,827 Views
17 Pages

Exploring the Ability of LARS2 Carboxy-Terminal Domain in Rescuing the MELAS Phenotype

  • Francesco Capriglia,
  • Francesca Rizzo,
  • Giuseppe Petrosillo,
  • Veronica Morea,
  • Giulia d’Amati,
  • Palmiro Cantatore,
  • Marina Roberti,
  • Paola Loguercio Polosa and
  • Francesco Bruni

10 July 2021

The m.3243A>G mutation within the mitochondrial mt-tRNALeu(UUR) gene is the most prevalent variant linked to mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome. This pathogenic mutation causes severe impair...

  • Article
  • Open Access
9 Citations
7,529 Views
10 Pages

Isolated Sphenoid Sinusitis: Anatomical Features for Choosing a Method of Treatment, a Case-Control Study

  • Sergei Karpishchenko,
  • Olga Vereshchagina,
  • Olga Stancheva,
  • Tatiana Nagornykh,
  • Alexander Krasichkov,
  • Irina Serdiukova,
  • Aleksandr Sinitca and
  • Dmitry Kaplun

Isolated sphenoid sinusitis (ISS) is a group of pathologies characterized by inflammation in one or both sphenoid sinuses. The gold standard for analyzing and diagnosing ISS is computer tomography. Many researchers have discussed the treatment of pat...

  • Article
  • Open Access
1 Citations
1,290 Views
20 Pages

The COVID-19 pandemic has highlighted the crucial role of health sector decision-makers in establishing and evaluating effective treatment and prevention policies. To inform sound decisions, it is essential to simultaneously monitor multiple pandemic...

  • Review
  • Open Access
22 Citations
7,861 Views
11 Pages

Neuropsychological Evaluations in Limbic Encephalitis

  • Juri-Alexander Witt and
  • Christoph Helmstaedter

Limbic encephalitis (LE) can cause dynamic and permanent impairment of cognition and behavior. In clinical practice, the question arises as to which cognitive and behavioral domains are affected by LE and which assessment is suited to monitor the dis...

  • Article
  • Open Access
17 Citations
4,215 Views
16 Pages

Optimizing Messenger RNA Analysis Using Ultra-Wide Pore Size Exclusion Chromatography Columns

  • Valentina D’Atri,
  • Honorine Lardeux,
  • Alexandre Goyon,
  • Mateusz Imiołek,
  • Szabolcs Fekete,
  • Matthew Lauber,
  • Kelly Zhang and
  • Davy Guillarme

Biopharmaceutical products, in particular messenger ribonucleic acid (mRNA), have the potential to dramatically improve the quality of life for patients suffering from respiratory and infectious diseases, rare genetic disorders, and cancer. However,...

  • Article
  • Open Access
7 Citations
7,497 Views
31 Pages

On Quantum Chosen-Ciphertext Attacks and Learning with Errors

  • Gorjan Alagic,
  • Stacey Jeffery,
  • Maris Ozols and
  • Alexander Poremba

Large-scale quantum computing poses a major threat to classical public-key cryptography. Recently, strong “quantum access” security models have shown that numerous symmetric-key cryptosystems are also vulnerable. In this paper, we conside...

  • Review
  • Open Access
56 Citations
9,579 Views
19 Pages

SARS-CoV-2 Reinfections and Long COVID in the Post-Omicron Phase of the Pandemic

  • Fotini Boufidou,
  • Snežana Medić,
  • Vicky Lampropoulou,
  • Nikolaos Siafakas,
  • Athanasios Tsakris and
  • Cleo Anastassopoulou

19 August 2023

We are reviewing the current state of knowledge on the virological and immunological correlates of long COVID, focusing on recent evidence for the possible association between the increasing number of SARS-CoV-2 reinfections and the parallel pandemic...

  • Article
  • Open Access
6 Citations
2,635 Views
21 Pages

RFS+: A Clinically Adaptable and Computationally Efficient Strategy for Enhanced Brain Tumor Segmentation

  • Abdulkerim Duman,
  • Oktay Karakuş,
  • Xianfang Sun,
  • Solly Thomas,
  • James Powell and
  • Emiliano Spezi

28 November 2023

Automated brain tumor segmentation has significant importance, especially for disease diagnosis and treatment planning. The study utilizes a range of MRI modalities, namely T1-weighted (T1), T1-contrast-enhanced (T1ce), T2-weighted (T2), and fluid-at...

  • Article
  • Open Access
1 Citations
1,941 Views
28 Pages

ED2IF2-Net: Learning Disentangled Deformed Implicit Fields and Enhanced Displacement Fields from Single Images Using Pyramid Vision Transformer

  • Xiaoqiang Zhu,
  • Xinsheng Yao,
  • Junjie Zhang,
  • Mengyao Zhu,
  • Lihua You,
  • Xiaosong Yang,
  • Jianjun Zhang,
  • He Zhao and
  • Dan Zeng

27 June 2023

There has emerged substantial research in addressing single-view 3D reconstruction and the majority of the state-of-the-art implicit methods employ CNNs as the backbone network. On the other hand, transformers have shown remarkable performance in man...

  • Article
  • Open Access
3 Citations
1,640 Views
16 Pages

Variable Penetrance and Expressivity of a Rare Pore Loss-of-Function Mutation (p.L889V) of Nav1.5 Channels in Three Spanish Families

  • María Gallego-Delgado,
  • Anabel Cámara-Checa,
  • Marcos Rubio-Alarcón,
  • David Heredero-Jung,
  • Laura de la Fuente-Blanco,
  • Josu Rapún,
  • Beatriz Plata-Izquierdo,
  • Sara Pérez-Martín,
  • Jorge Cebrián and
  • Lucía Moreno de Redrojo
  • + 5 authors

A novel rare mutation in the pore region of Nav1.5 channels (p.L889V) has been found in three unrelated Spanish families that produces quite diverse phenotypic manifestations (Brugada syndrome, conduction disease, dilated cardiomyopathy, sinus node d...

  • Article
  • Open Access
1,034 Views
25 Pages

26 April 2025

Rain gardens are efficient nature-based solutions (NBSs) for the sustainable management of surface run-off in urban areas. The functionality of a rain garden in an urban environment depends on the resistance of plant and soil components to anthropoge...