Search Results (6,561)

Antioxidants are essential bioactive compounds widely recognized for their health benefits in preventing oxidative stress-related diseases. However, many lipophilic antioxidants suffer from poor aqueous solubility, low chemical stability, and limited bioavailability, restricting their application in food, nutraceutical, and pharmaceutical industries. Cyclodextrins (CDs), a class of cyclic oligosaccharides with a hydrophilic exterior and lipophilic interior, present an effective strategy to encapsulate and deliver these compounds by improving their solubility, stability, and therapeutic efficacy. This review critically examines the structural features and derivatives of cyclodextrins relevant for antioxidant encapsulation, mechanisms and thermodynamics of inclusion complex formation, and advanced characterization techniques. It evaluates the influence of CD encapsulation on the oral bioavailability and antioxidant activity of various lipophilic antioxidants supported by recent in vitro and in vivo studies. Moreover, sustainable preparation methods for CD complexes are discussed alongside safety and regulatory considerations. The comprehensive synthesis of current knowledge contributes to guiding the rational design and development of CD-based antioxidant nutraceuticals, addressing formulation challenges while promoting efficacy and consumer safety. Full article

The aim of this review was to harmonize major consensus statements (European Working Group on Sarcopenia in Older People 2; Asian Working Group for Sarcopenia 2019; Foundation for the National Institutes of Health Sarcopenia Project operational criteria) into a stage- and setting-stratified algorithm. It maps diagnostic strata to dose-defined resistance and combined training, integrates multimodal and technology-enabled options (whole-body electrical muscle stimulation, whole-body vibration, virtual reality, AI-assisted telerehabilitation) with safety cues, and embeds nutrition (≥1.2 g/kg/day protein, vitamin D, key micronutrients) and education to sustain adherence. Sarcopenia is a consequential geriatric syndrome linked to falls, loss of independence, hospitalization, mortality, and psychosocial burden, yet translation to practice is hindered by heterogeneous definitions, diagnostics, and treatment guidance. Literature searches via PubMed/MEDLINE, EBSCO, SciELO, and Google Scholar (January 2000 to August 2025) yielded 354 records; after screening and deduplication, 132 peer-reviewed studies were included. We summarize tools for screening, strength, muscle mass, and function (e.g., Sarcopenia Five-Item Questionnaire, grip strength, dual-energy X-ray absorptiometry, gait speed) and identify resistance exercise as the cornerstone, with aerobic, balance, and flexibility training adding functional and metabolic benefits. Clinic-ready tables and figures operationalize a stepwise program across primary to severe sarcopenia and across acute or iatrogenic to community settings. Early screening plus structured, exercise-centered care, augmented by targeted nutrition and education, offers pragmatic, scalable benefits. Full article

With the rapid expansion of urban transportation networks, new metro tunnels frequently cut through existing structures’ diaphragm walls by using the shield machine. Such intrusions induce dynamic disturbances that pose significant risks to adjacent structures. This study employs Suzhou Metro Line 8 as a case study to evaluate the safety of existing metro stations during shield tunneling, specifically examining deformation characteristics induced by varying tunneling parameters. A three-dimensional numerical model is developed to assess structural responses, with simulation accuracy rigorously validated against field measurements. Results reveal that the transverse influence zone of the base slab extends approximately 2.5 times the tunnel diameter. Diaphragm wall exhibits horizontal deformation opposite the tunneling direction, while the maximum lateral deformation of adjacent station walls reaches 2.49 mm. Concurrently, a slight uplift manifests at the base slab center with a peak value of 2.54 mm. All obtained structural deformations remain well below the permission value of 5 mm, with observed maxima constituting only 50% of this safety threshold. This substantial deformation margin significantly mitigates construction hazards, promoting the sustainable development of underground space. Full article

The paper proposes a multi-objective approach for optimizing the structure of electric power generation amid tightening requirements for the energy efficiency and environmental safety of power systems. The study identifies relevant directions for improving advanced natural gas-fired power plants. An algorithm for the multi-objective optimization of the power generation structure has been developed, based on the sequential application of mathematical tools such as principal component analysis, Pareto optimization, and the entropy-based TOPSIS method. It has been established that under the model’s given constraints, the share of highly efficient energy complexes in Pareto-optimal generation structures typically does not exceed 40% of the total generating capacity, while the share of low-carbon complexes does not exceed 60%. Furthermore, as the energy planning horizon extends, the share of carbon-free energy complexes in the most efficient generation structures increases, reaching 51% with the introduction of generating capacity in 2031, and 92% with a system commissioning date in 2035. The proposed methodology enables a quantitative analysis of the evolution of the optimal electric power generation structure over time, highlighting a priority pathway for the development of sustainable energy. Full article

Traffic safety analysis has traditionally relied on historical road collision data. However, this approach has many limitations due to well-known challenges with the availability and quality of collision data. Moreover, collecting sufficient crash data to develop statistical models for traffic safety analysis is only possible after the societal damage due to collisions has been sustained. Those problems are more likely when studying pedestrian safety. To address these constraints, researchers utilize traffic conflict indicators to identify the severity of conflicts and develop strategies to enhance road safety. This study evaluates Ultra-Wideband (UWB) technology for estimating the post-encroachment time (PET) indicator, a commonly used measure in pedestrian safety. Indoor experiments were conducted to explore potential multipath issues commonly encountered in wireless-based localization systems. The time-division multiple access (TDMA) scheme was utilized by assigning 20 ms time slots for stable communication between a tag and an anchor. To address the different clocks in UWB anchors and tags, the master–slave technique was employed for time synchronization between the devices. The experiments also examined the storage of UWB measurements using a cloud-based global clock for time synchronization. The study found that the mean absolute error (MAE) in PET is 4.92 s under interference conditions and 0.148 s with the TDMA technique between the ground truth and the UWB measurements. The findings offer valuable insights for future studies aimed at enhancing UWB accuracy. Full article

This article deals with the possibility of using a recycled aggregate from railway ballast and platforms for the production of cement composites with a full or partial replacement of natural aggregates. This study evaluates the physical and mechanical properties of fresh and hardened concrete, as well as its resistance to water pressure, microstructure, and environmental safety. Four concrete recipes using an aggregate at the end of its life cycle from railway ballast (0/25 mm) and from the layers under the asphalt covering of the platforms (0/32 mm) were designed, with a 100% replacement for 0/25, 55% replacement (coarse fraction) for 0/32, and 45% sand for 0/4. The results have shown a significant influence of the type of aggregate on the strength, bulk density, and watertightness of the concrete. At 28 days, the compressive strengths of mixes R250, R400, R250N, and R400N were approximately 8, 20, 30, and 35 MPa, respectively, while after 90 days they increased to 10, 22, 37, and 45 MPa. The corresponding fresh concrete bulk densities ranged from about 1.95 to 2.27 g/cm³, and the water penetration depths ranged between 16 mm (best) and 27 mm (worst) among the mixes. Analyses of aqueous leachates have confirmed that the cement matrix effectively stabilizes the contaminants contained in the recycled aggregate and that the resulting products comply with the legislative limits. This study shows that an aggregate at the end of its life cycle from railway ballast and platforms can be effectively used to produce sustainable cement composites (concrete) with suitable mechanical properties and minimal environmental risks. Full article

Background: Community pharmacies are increasingly delivering structured services to support chronic disease management, such as Multidose Drug Dispensing (MDD). This strategy can improve adherence and safety, but evidence of its economic feasibility in Portuguese pharmacies remains limited. Objective: To estimate the cost of implementing and operating an MDD system in a community pharmacy, informing reimbursement models and policy. Methods: A micro-costing approach assessed fixed and variable expenses for serving polymedicated elderly patients. Costs were calculated in euros (2024/2025) and expressed per working day based on 253 annual preparation days. Results: First-year costs totaled €70 985.68, including €8 184.00 for setup, €21 579.00 for supplies, and €41 222.68 for staff salaries. The daily operating cost was €280.58, with labour representing the major expense. A break-even analysis indicated sustainability with around 700 users at €10/month. Conclusion: Although requiring significant initial investment, MDD can become financially viable through scaling, workflow efficiency, and supportive reimbursement strategies. Full article

Airport pavement condition assessment plays a critical role in ensuring operational safety, surface functionality, and long-term infrastructure sustainability. Traditional visual inspection methods, although widely used, are increasingly challenged by limitations in accuracy, subjectivity, and scalability. In response, the field has seen a growing adoption of automated and intelligent inspection technologies, incorporating tools such as unmanned aerial vehicles (UAVs), Laser Crack Measurement Systems (LCMS), and machine learning algorithms. This systematic review aims to identify, categorize, and analyze the main technological approaches applied to functional pavement inspections, with a particular focus on surface distress detection. The study examines data collection techniques, processing methods, and validation procedures used in assessing both flexible and rigid airport pavements. Special emphasis is placed on the precision, applicability, and robustness of automated systems in comparison to traditional approaches. The reviewed literature reveals a consistent trend toward greater accuracy and efficiency in systems that integrate deep learning, photogrammetry, and predictive modeling. However, the absence of standardized validation protocols and statistically robust datasets continues to hinder comparability and broader implementation. By mapping existing technologies, identifying methodological gaps, and proposing strategic research directions, this review provides a comprehensive foundation for the development of scalable, data-driven airport pavement management systems. Full article

Background: The management of symptomatic uterine fibroids in women of reproductive age remains a clinical challenge, with uterine preservation being a primary objective in order to safeguard fertility. To date, no clear consensus has been established in the literature regarding the optimal treatment strategy, as therapeutic choices largely depend on individual patient characteristics. In selected cases, the use of preoperative measures aimed at minimizing the risk of major intraoperative hemorrhage has been associated with an increased likelihood of adopting a more conservative surgical approach. Case presentation: We report the case of a young patient treated at our institution who presented large uterine fibroids and underwent Preoperative Uterine Artery Embolization (PUAE) before planned open myomectomy with positive outcomes. In our case, this approach provided excellent intraoperative hemostatic control, minimizing blood loss. At post-discharge follow-up, the patient showed marked symptom relief and improved quality of life. Long-term follow-up will assess sustained treatment efficacy. Conclusions: PUAE should be considered a valuable therapeutic option in patients with symptomatic uterine fibroids at high risk of surgical bleeding. When integrated into a multidisciplinary treatment plan, PUAE may enhance surgical safety, support fertility preservation, and broaden the range of conservative options available for women with complex fibroid disease. Full article

Betaine (BET)-based deep eutectic solvents (DESs) have emerged as promising substitutes for traditional organic solvents owing to their eco-friendly properties and versatility in various applications. This review provides a comprehensive overview of the current status and future perspectives of BET-based DESs, highlighting their definition, characteristics, and mechanisms of eutectic formation. The unique properties of BET, including its biodegradability and non-toxicity, make it an attractive hydrogen bond acceptor in the formulation of DESs. The review discusses common methods for preparing BET-based DESs and emphasizes their applications in extraction processes, catalysis, biocompatibility, and pharmaceutical applications. Additionally, challenges such as stability and fluidity limitations are addressed, along with regulatory and safety considerations. Future directions suggest an increasing industrial application of BET-based DESs in environmentally sustainable processes within the food and pharmaceutical sectors, underlining their potential as green solvents in next-generation chemical methodologies. Full article

Bacteriophages, or phages, are viruses that infect and kill specific bacteria, offering a promising alternative to antibiotics in livestock production. With growing concerns over antibiotic resistance, phages have gained renewed interest due to their ability to target harmful pathogens without disturbing beneficial gut microbiota. This review explores the application of dietary phage supplementation in monogastric animals, particularly pigs and poultry. In pigs, phage use has demonstrated beneficial effects such as improved growth performance, enhanced gut health, and reduced infections from Salmonella and E. coli. Various delivery methods, including feed and water supplementation, have been studied, with microencapsulation showing promising results for stability and effectiveness. Similarly, in poultry, phages have been successfully used to control pathogens like Salmonella, Campylobacter, and avian pathogenic E. coli, improving gut health, immunity, and overall performance. Several commercial phage products are already in use, demonstrating both safety and efficacy. Despite these advantages, challenges such as a narrow host range, bacterial resistance, and regulatory limitations remain. Therefore, further research is necessary to understand phage–host interactions, optimize delivery strategies, and evaluate long-term effects under normal and disease-free conditions. This review highlights the potential of bacteriophages as safe, targeted, and sustainable alternatives to antibiotics in monogastric animal production, contributing to improved animal health and reduced antibiotic use. Full article

The rapid advancement of Advanced Driver Assistance Systems (ADAS) is reshaping the future of mobility by offering potential improvements in safety, efficiency, and driving experience, yet consumer acceptance remains uneven across regions. This study addresses the gap in knowledge and trust by examining how Hungarian drivers, as part of the Central and Eastern European context, perceive and adopt ADAS technologies. To achieve this, we conducted two expert in-depth interviews to refine the research instrument, followed by an online survey of 179 drivers. Using k-means cluster analysis, we identified three distinct consumer segments: Conservative Controllers, who demonstrate low levels of trust and willingness to adopt ADAS; Cautious Adopters, who weigh costs and benefits carefully; and Pragmatic Innovators, who are open to experimentation and display the highest acceptance and willingness to pay. The results reveal that awareness and familiarity strongly influence acceptance, highlighting the role of consumer education and transparent communication in shaping adoption. The findings suggest that manufacturers, driving schools, and policymakers can accelerate the diffusion of ADAS by developing targeted strategies tailored to different consumer groups. Strengthening knowledge and trust in these systems will not only support their market success but also contribute to safer, more sustainable transportation. Full article

As hydrogen emerges as a key vector in the shift toward cleaner energy systems, the evaluation of storage technologies becomes essential to support its integration across diverse applications. This work provides a comparative analysis of four hydrogen storage methods, compressed gas, metal hydrides, metal–organic frameworks (MOFs), and carbon-based materials, using a structured multi-criteria decision-making (MCDM) approach, specifically the Analytic Hierarchy Process (AHP) and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). The evaluation is based on a comprehensive set of technical, economic, and environmental criteria, including safety, storage capacity, efficiency, cycle durability, technological maturity, environmental impact, cost, and scalability. The analysis adopts a technology-oriented perspective, focusing on the intrinsic performance and feasibility of hydrogen storage systems rather than on a detailed techno-economic optimization. The results show that metal hydrides offer the most balanced performance, driven by high volumetric capacity and solid-phase stability, followed closely by compressed hydrogen, which stands out for its technological maturity and well-established infrastructure, despite facing significant challenges related to safety and space efficiency due to high-pressure storage requirements. Carbon-based materials and MOFs, although promising in specific aspects such as safety, storage density, or material sustainability, are hindered by technological immaturity and operational limitations. Full article

This study examines the travel behaviour and motivations of tourists visiting heritage attractions in the Sekhukhune District Municipality (SDM) in South Africa, as part of the sustainable development of rural heritage tourism. A quantitative approach through a means of a questionnaire was used to collect data from a sample size of 208 respondents at major heritage attractions in the study area. The results indicate that the respondents are primarily motivated by cultural performances, historical stories and sites associated with mining and agricultural heritage. This study identified that tourists are more concerned about the level of crime and environmental degradation as inhibiting factors to their attitudes and behaviours of participation. This study also demonstrates the socio-economic and environmental barriers rural municipalities deal with. This study provides practical recommendations for enhancing cultural engagement, addressing safety concerns, and promoting local economic development, thereby fostering a more sustainable and inclusive approach to heritage tourism in the SDM. Full article

Rising energy demand, fossil fuel depletion, and global warming are accelerating research into sustainable energy solutions, with growing interest in hydrogen as a promising alternative. This research presents a detailed experimental investigation and novel digital twin (DT) models for an integrated hydrogen-based energy system consisting of an Anion Exchange Membrane Electrolyzer (AEMEL), Proton Exchange Membrane Fuel Cell (PEMFC), hydrogen storage, and Battery Energy Storage System (BESS). Conducted at a real-world facility in Risavika, Norway, the study employed commercial units: the Enapter EL 4.1 AEM electrolyzer and Intelligent Energy IE-Lift 1T/1U PEMFC. Experimental tests under dynamic load conditions demonstrated stable operation, achieving hydrogen production rates of up to 512 NL/h and a specific power consumption of 4.2 kWh/Nm³, surpassing the manufacturer’s specifications. The PEMFC exhibited a unique cyclic operational mechanism addressing cathode water flooding, a critical issue in fuel cell systems, achieving steady-state efficiencies around 43.6% under prolonged (190 min) rated-power operation. Subsequently, advanced DT models were developed for both devices: a physics-informed interpolation model for the AEMEL, selected due to its linear and steady operational behavior, and an ANN-based model for the PEMFC to capture its inherently nonlinear, dynamically fluctuating characteristics. Both models were validated, showing excellent predictive accuracy (<3.8% deviation). The DTs integrated manufacturer constraints, accurately modeling transient behaviors, safety logic, and operational efficiency. The round-trip efficiency of the integrated system was calculated (~27%), highlighting the inherent efficiency trade-offs for autonomous hydrogen-based energy storage. This research significantly advances our understanding of integrated H₂ systems, providing robust DT frameworks for predictive diagnostics, operational optimization, and performance analysis, supporting the broader deployment and management of hydrogen technologies. Full article