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60,489 Results Found

  • Article
  • Open Access
3 Citations
4,475 Views
12 Pages

Lunar habitat design is a complex endeavor characterized by complicated task-composition, numerous internal iterations, and intense task-coupling. The design process of assembled building in terrestrial construction and the system composition of luna...

  • Article
  • Open Access
895 Views
13 Pages

Optimization of Insulation Structure Design for Enameled Wires Based on Molecular Structure Design

  • Yang Yu,
  • Siyuan Li,
  • Ling Weng,
  • Xiaorui Zhang,
  • Laiweiqing Liu and
  • Qingguo Chen

8 April 2025

The performance of enameled wires has an important impact on new energy vehicle motors. The mainstream practice of existing technology is to improve partial discharge inception voltage (PDIV) by doping powder to inhibit corona and increase varnish th...

  • Article
  • Open Access
4 Citations
2,648 Views
24 Pages

Neck Structure Optimal Design of the Turbine Wheel for Containment Design of the Air Turbine Starter

  • Liqiang Chen,
  • Haijun Xuan,
  • Wenbin Jia,
  • Jianxin Liu,
  • Zehui Fang and
  • Yao Zheng

14 September 2023

The airworthiness standards of the transport category airplanes stipulate that the high energy rotor equipment must be of the sufficient containment capacity. It is of great importance to study the containment and weight reduction for the air turbine...

  • Article
  • Open Access
19 Citations
7,974 Views
21 Pages

23 March 2024

Lightweight structures with a high stiffness-to-weight ratio always play a significant role in weight reduction in the aerospace sector. The exploration of non-conventional structures for aerospace applications has been a point of interest over the p...

  • Article
  • Open Access
3 Citations
4,833 Views
18 Pages

15 March 2023

In this work, the aerodynamic and structural design of the fairing for vehicles was carried out. The Rankine half body theory, which is one of the theories being used for the aircraft gas turbine engine inlets and turboprop nose cones was adopted for...

  • Review
  • Open Access
32 Citations
16,155 Views
16 Pages

Structure-Based Design of Ricin Inhibitors

  • Karl Jasheway,
  • Jeffrey Pruet,
  • Eric V. Anslyn and
  • Jon D. Robertus

13 October 2011

Ricin is a potent cytotoxin easily purified in large quantities. It presents a significant public health concern due to its potential use as a bioterrorism agent. For this reason, extensive efforts have been underway to develop antidotes against this...

  • Article
  • Open Access
8 Citations
3,182 Views
15 Pages

11 January 2023

Owing to their high design freedom and excellent performance, lattice structures have shown outstanding capabilities and great potential in aeronautics and astronautics fields. In this paper, we propose a method to construct lattice structures by par...

  • Article
  • Open Access
14 Citations
4,846 Views
19 Pages

6 January 2023

According to different working environments and functional requirements, radial magnetic bearings (RMBs) have various design methods. Some methods’ lack of effectiveness or accuracy is likely to cause significant differences in the structural p...

  • Review
  • Open Access
10 Citations
10,593 Views
24 Pages

Structure and Dynamics Guiding Design of Antibody Therapeutics and Vaccines

  • Monica L. Fernández-Quintero,
  • Nancy D. Pomarici,
  • Anna-Lena M. Fischer,
  • Valentin J. Hoerschinger,
  • Katharina B. Kroell,
  • Jakob R. Riccabona,
  • Anna S. Kamenik,
  • Johannes R. Loeffler,
  • James A. Ferguson and
  • Hailee R. Perrett
  • + 3 authors

18 October 2023

Antibodies and other new antibody-like formats have emerged as one of the most rapidly growing classes of biotherapeutic proteins. Understanding the structural features that drive antibody function and, consequently, their molecular recognition is cr...

  • Review
  • Open Access
13 Citations
1,504 Views
32 Pages

Chemical Structure Indices in In Silico Molecular Design

  • Yenamandra S. PRABHAKAR and
  • Manish K. GUPTA

7 May 2008

The chemical structure indices have a significant role in providing direction to the design of chemotherapeutic agents. These indices come from the experimental domain as well as through the computations. While the experimental properties of compound...

  • Abstract
  • Open Access
797 Views
1 Page

This study delves into the realms of Parametric Design and Auxetic Structures, focusing on structures exhibiting unconventional behavior, i.e., those that have a mechanical function inverse to the conventional one and expand when subjected to an exte...

  • Article
  • Open Access
4 Citations
4,912 Views
20 Pages

GD (Generative Design) Applied to a Plastics Recovery Drone (PRD) Using IDeS (Industrial Design Structure)

  • Leonardo Frizziero,
  • Alfredo Liverani,
  • Giampiero Donnici,
  • Enrico Conti,
  • Beatrice Dello Preite,
  • Umberto Lamanna,
  • Christian Leon-Cardenas and
  • Matteo Garulli

The evolution of innovative and systematic design methodologies over time has widened the design concept involvement from the product development phase, which also includes the production and start-up phases. Literature findings have presented to acc...

  • Article
  • Open Access
19 Citations
3,905 Views
12 Pages

1 April 2021

In this work, structural design and manufacturing of sandwich composite floor for automobile was performed. The tensile and compression strength of specimen were investigated. Based on this, structural design of floor board was performed. The sandwic...

  • Article
  • Open Access
14 Citations
5,384 Views
18 Pages

Lattice Structure Design Method Aimed at Energy Absorption Performance Based on Bionic Design

  • Gang He,
  • Hu Yang,
  • Tao Chen,
  • Yuan Ning,
  • Huatao Zou and
  • Feng Zhu

21 October 2022

To obtain the lattice structure with excellent energy absorption performance, the structure of loofah inner fiber is studied to develop bionic design of lattice structure by experiment and simulation analysis method. From the compression experiment a...

  • Article
  • Open Access
4 Citations
2,559 Views
12 Pages

Design Optimisation of a Cable–Strut Tensile Structure According to the Importance of Elements

  • Lian-Meng Chen,
  • Ze-Bin Li,
  • He Zhang,
  • Yi-Jie Liu,
  • Yi-Hong Zeng,
  • Yi-Yi Zhou and
  • Shi-Lin Dong

25 September 2022

In this study, the design of a flexible cable–strut tensile structure was optimised according to the importance of elements to achieve high structural robustness. First, the importance coefficients of elements were determined by comparing their...

  • Article
  • Open Access
6 Citations
3,350 Views
21 Pages

17 September 2020

Various types of support structures for offshore wind turbine have been developed, and concrete structures have attracted attention due to many advantages. Although many studies have been conducted on the design of the existing steel structures, info...

  • Article
  • Open Access
4 Citations
2,031 Views
22 Pages

31 January 2023

With the intelligent tool cutting force measurement model as the engineering background, the selection, design, and optimization of the substrate structure of the tool-embedded thin-film strain sensor are studied. The structure of the thin-film strai...

  • Review
  • Open Access
8 Citations
3,972 Views
15 Pages

21 January 2023

The α-kinase, eEF2K, phosphorylates the threonine 56 residue of eEF2 to inhibit global peptide elongation (protein translation). As a master regulator of protein synthesis, in combination with its unique atypical kinase active site, investigati...

  • Article
  • Open Access
2 Citations
1,674 Views
12 Pages

Structure Design and Optimization of MRE Vibration Isolator

  • Shuaijun Wang,
  • Yi Zhao,
  • Han Lei,
  • Shaomin Li,
  • Hao Fang and
  • Dahua Ye

17 December 2024

As an intelligent component, the high-performance MRE vibration isolator has great advantages, such as a wide vibration isolation frequency range and good performance in semi-active vibration reduction applications. In order to develop high-performan...

  • Review
  • Open Access
12 Citations
6,205 Views
18 Pages

Targeting Viral Surface Proteins through Structure-Based Design

  • Yogesh B Narkhede,
  • Karen J Gonzalez and
  • Eva-Maria Strauch

8 July 2021

The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. It warrants the establishment of better interventions and protective therapies to combat the...

  • Article
  • Open Access
9 Citations
2,389 Views
22 Pages

30 June 2023

The accurate analysis of key components of a spherical hinge structure directly affects bridge quality and safety during construction. Considering the key components of a spherical joint structure as the research object, a refined calculation model f...

  • Review
  • Open Access
16 Citations
4,666 Views
16 Pages

5 May 2021

A hepatitis C virus (HCV) vaccine is a critical yet unfulfilled step in addressing the global disease burden of HCV. While decades of research have led to numerous clinical and pre-clinical vaccine candidates, these efforts have been hindered by fact...

  • Article
  • Open Access
566 Views
15 Pages

3 November 2025

Within contemporary railway engineering, manufacturers of rolling stock are increasingly focused on developing vehicles that combine reduced weight with enhanced reliability. This objective is largely motivated by the need to decrease energy demand a...

  • Article
  • Open Access
1 Citations
2,740 Views
14 Pages

25 August 2023

Aiming at the problems of difficult construction and occlusion of the initial structure of an automotive augmented reality head-up display (AR-HUD), a method to quickly build the initial structure of an automotive AR-HUD is proposed. Firstly, the pos...

  • Article
  • Open Access
1 Citations
3,440 Views
13 Pages

24 February 2023

The optimal size of a diversion structure should be carefully studied to ensure economic viability and safety during construction. In practice, to determine the size of a diversion structure, design flood frequency is selected as the suggested return...

  • Article
  • Open Access
12 Citations
3,753 Views
17 Pages

28 January 2023

In the current digital era, where Unmanned Aerial Vehicles (UAVs), Artificial intelligence (AI), and Internet of Everything (IoE) can be well integrated, more global connectivity and automated solutions can be witnessed. This paper aims to develop an...

  • Article
  • Open Access
10 Citations
3,805 Views
18 Pages

Due to its excellent performance and high design freedom, the lattice structure has shown excellent capabilities and considerable potential in aerospace and other fields. Inspired by the bamboo structure, a lattice cell configuration namely BCC4IZ is...

  • Article
  • Open Access
11 Citations
10,394 Views
21 Pages

Thermo-Structural Response Caused by Structure Gap and Gap Design for Solid Rocket Motor Nozzles

  • Lin Sun,
  • Futing Bao,
  • Ning Zhang,
  • Weihua Hui,
  • Shaozeng Wang,
  • Nan Zhang and
  • Heng Deng

2 June 2016

The thermo-structural response of solid rocket motor nozzles is widely investigated in the design of modern rockets, and many factors related to the material properties have been considered. However, little work has been done to evaluate the effects...

  • Article
  • Open Access
758 Views
25 Pages

The geometric structure design of three-layer hollow fan blades is extremely complex, which is not only directly related to the blade quality and manufacturing cost but also has a significant impact on engine performance. Based on geometric algorithm...

  • Article
  • Open Access
1 Citations
1,574 Views
22 Pages

16 December 2024

In the requirement-driven forward design process of civil aircraft, the large number of design tasks of complex systems with varying difficulty and the complex relationships between design tasks lead to unnecessary repetitive design iterations. In or...

  • Review
  • Open Access
12 Citations
5,709 Views
19 Pages

Structure-Based Drug Design for Tuberculosis: Challenges Still Ahead

  • Eduardo M. Bruch,
  • Stéphanie Petrella and
  • Marco Bellinzoni

20 June 2020

Structure-based and computer-aided drug design approaches are commonly considered to have been successful in the fields of cancer and antiviral drug discovery but not as much for antibacterial drug development. The search for novel anti-tuberculosis...

  • Article
  • Open Access
2 Citations
6,330 Views
27 Pages

IDeS (Industrial Design Structure) Method Applied to the Automotive Design Framework: Two Sports Cars with Shared Platform

  • Leonardo Frizziero,
  • Christian Leon-Cardenas,
  • Gabriele Colasurdo,
  • Alessandro Vicaretti and
  • Alfredo Liverani

The present study was set to validate two different suburban-type sportscar bodies with shared common underpinnings. The chosen method to develop this project was the Industrial Design Structure (IDeS), which characterizes the ability to use the diff...

  • Article
  • Open Access
768 Views
31 Pages

28 August 2025

As global manufacturing faces rising energy costs, environmental pressures, and machining precision, the development trends of the machine tools are moving towards lightweight and high-rigidity structures. While those approaches of increasing key com...

  • Article
  • Open Access
5 Citations
4,133 Views
28 Pages

Optimization of a Truss Structure Used to Design of the Manipulator Arm from a Set of Components

  • Jaroslav Rojíček,
  • Zbyněk Paška,
  • Martin Fusek,
  • Zdenko Bobovsky,
  • Alžbeta Sapietová,
  • Vladimír Mostýn and
  • Dagmar Ličová

30 October 2021

The design of a manipulator arm, which is built from a construction kit, is presented in this article. The procedure is based on the results of the discrete optimization of a truss structure and its application to a simple component system (assuming...

  • Feature Paper
  • Article
  • Open Access
6 Citations
4,924 Views
22 Pages

Design and Optimization of a Curved-Crease-Folding Process Applied to a Light Metallic Structure

  • Doina Raducanu,
  • Vasile Danut Cojocaru,
  • Vlad Andrei Raducanu,
  • Anna Nocivin,
  • Nicolae Serban,
  • Ion Cinca,
  • Elisabeta Mirela Cojocaru,
  • Laurentiu Moldovan,
  • Corneliu Trisca-Rusu and
  • Irina Varvara Balkan

25 June 2021

Presently, the realization of complex, unconventional designs using efficient modalities is possible due to an increasing interest in interdisciplinary approaches: materials science, mathematics, IT, architecture, etc. Computerized techniques, among...

  • Article
  • Open Access
8 Citations
3,802 Views
26 Pages

Integrated Structure-Control Design of a Bipedal Robot Based on Passive Dynamic Walking

  • Josué Nathán Martínez-Castelán and
  • Miguel Gabriel Villarreal-Cervantes

24 June 2021

The design of bipedal robots is generally fulfilled through considering a sequential design approach, where a synergistic relationship between its structure and control features is not promoted. Hence, a novel integrated structure-control design appr...

  • Article
  • Open Access
12 Citations
3,079 Views
15 Pages

4 August 2023

In order to study the influence of the cavity inclination angle bending performance of pneumatic soft actuators, two kinds of soft actuators were designed, one with a five-degree-angle cavity structure, and the other with a hybrid variable-degree-ang...

  • Article
  • Open Access
17 Citations
2,586 Views
16 Pages

An Aggregation-Free Local Volume Fraction Formulation for Topological Design of Porous Structure

  • Kai Long,
  • Zhuo Chen,
  • Chengwan Zhang,
  • Xiaoyu Yang and
  • Nouman Saeed

30 September 2021

Cellular structure can possess superior mechanical properties and low density simultaneously. Additive manufacturing has experienced substantial progress in the past decades, which promotes the popularity of such bone-like structure. This paper propo...

  • Article
  • Open Access
4 Citations
3,293 Views
14 Pages

Optimisation of Cable Dome Structure Design for Progressive Collapse Resistance

  • Lian-Meng Chen,
  • Kai-Yu Huang,
  • Yi-Jie Liu,
  • Yi-Hong Zeng,
  • Ze-Bin Li,
  • Yi-Yi Zhou and
  • Shi-Lin Dong

6 February 2023

Since the literature lacks an effective analysis method of collapse mechanisms and optimisation design theory for progressive collapse resistance of cable dome structure, a structural performance-based optimisation approach was proposed to improve th...

  • Article
  • Open Access
3 Citations
5,507 Views
27 Pages

Application of IDeS (Industrial Design Structure) to Sustainable Mobility: Case Study of an Innovative Bicycle

  • Leonardo Frizziero,
  • Alfredo Liverani,
  • Giampiero Donnici,
  • Ilaria Giuliano,
  • Maria Grazia Picciariello,
  • Maria Luigia Tucci,
  • Donald Reimer and
  • Ahad Ali

The present study aims to validate a new research method called IDeS (industrial design structure) through the design of an electric bicycle for everyday city life. IDeS is the latest evolution of a combination of innovative and advanced systematic a...

  • Article
  • Open Access
36 Citations
11,408 Views
31 Pages

Buckling Analysis of a Thin-Walled Structure Using Finite Element Method and Design of Experiments

  • Mohamad Norfaieqwan Bin Kamarudin,
  • Jaffar Syed Mohamed Ali,
  • Abdul Aabid and
  • Yasser E. Ibrahim

23 September 2022

In structural engineering, thin-walled structures play an important role in the design of the lightweight structural model. It carries different loading conditions when it exists in any model, and it is designed with thin plates or thin shells. Penet...

  • Article
  • Open Access
5 Citations
3,034 Views
14 Pages

28 March 2021

The fluid–structure interaction (FSI) effect has a significant impact on the static and dynamic performance of aerostatic spindles, which should be fully considered when developing a new product. To enhance the overall performance of aerostatic spind...

  • Feature Paper
  • Article
  • Open Access
31 Citations
9,620 Views
17 Pages

Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors

  • Willem Jespers,
  • Ana Oliveira,
  • Rubén Prieto-Díaz,
  • María Majellaro,
  • Johan Åqvist,
  • Eddy Sotelo and
  • Hugo Gutiérrez-de-Terán

10 November 2017

The four receptors that signal for adenosine, A1, A2A, A2B and A3 ARs, belong to the superfamily of G protein-coupled receptors (GPCRs). They mediate a number of (patho)physiological functions and have attracted the interest of the biopharmaceutical...

  • Article
  • Open Access
5 Citations
11,847 Views
26 Pages

Temporary pavilions play an important role as experimental fields for architects, designers, and engineers, in addition to providing exhibition spaces. Novel structural and formal solutions applied in pavilions also can give them an unusual appearanc...

  • Review
  • Open Access
30 Citations
7,824 Views
28 Pages

Structure-Based Design of Novel MAO-B Inhibitors: A Review

  • Emilio Mateev,
  • Maya Georgieva,
  • Alexandrina Mateeva,
  • Alexander Zlatkov,
  • Shaban Ahmad,
  • Khalid Raza,
  • Vasco Azevedo and
  • Debmalya Barh

16 June 2023

With the significant growth of patients suffering from neurodegenerative diseases (NDs), novel classes of compounds targeting monoamine oxidase type B (MAO-B) are promptly emerging as distinguished structures for the treatment of the latter. As a pro...

  • Article
  • Open Access
16 Citations
6,466 Views
22 Pages

Structure Design of GFRP Composite Leaf Spring: An Experimental and Finite Element Analysis

  • Linlin Ma,
  • Jingwu He,
  • Yizhuo Gu,
  • Zuoguang Zhang,
  • Zechuan Yu,
  • Ao Zhou,
  • Lik-ho Tam and
  • Chao Wu

7 April 2021

Due to the high load-bearing capacity and light weight, composite leaf spring with variable width and variable thickness has been increasingly used in the automobile industry to replace the conventional steel leaf spring with a heavy weight. The opti...

  • Article
  • Open Access
10 Citations
3,040 Views
16 Pages

14 May 2020

The hyporheic zone (HZ), the region beneath or alongside a streambed, can play a vital role in a stream ecosystem. Previous studies have examined the impacts of in-stream structures on the HZ and river restoration; however, studies on optimizing the...

  • Article
  • Open Access
23 Citations
5,660 Views
16 Pages

30 August 2021

Due to its excellent performance and high design freedom, the lattice structure has shown excellent capabilities and considerable potential in aerospace and other fields. This paper proposes a method to map the biometric model to the lattice structur...

  • Article
  • Open Access
16 Citations
5,516 Views
34 Pages

5 March 2021

Welding is a consolidated technology used to manufacture/assemble large products and structures. Currently, welding design issues are tackled downstream of the 3D modeling, lacking concurrent development of design and manufacturing engineering activi...

  • Article
  • Open Access
7 Citations
2,926 Views
18 Pages

DBN Structure Design Algorithm for Different Datasets Based on Information Entropy and Reconstruction Error

  • Jianjun Jiang,
  • Jing Zhang,
  • Lijia Zhang,
  • Xiaomin Ran,
  • Jun Jiang and
  • Yifan Wu

4 December 2018

Deep belief networks (DBNs) of deep learning technology have been successfully used in many fields. However, the structure of a DBN is difficult to design for different datasets. Hence, a DBN structure design algorithm based on information entropy an...

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