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Article

20 Citations

3,760 Views

28 Pages

Assessment of Pharmacological Interactions between SIRT2 Inhibitor AGK2 and Paclitaxel in Different Molecular Subtypes of Breast Cancer Cells

Anna Wawruszak,
Jarogniew Luszczki,
Arkadiusz Czerwonka,
Estera Okon and
Andrzej Stepulak

Cells2022, 11(7), 1211;https://doi.org/10.3390/cells11071211

4 April 2022

Breast carcinoma (BC) is the most commonly diagnosed type of cancer in women in the world. Although the advances in the treatment of BC patients are significant, numerous side effects, severe toxicity towards normal cells as well as the multidrug res...

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Article

6 Citations

2,942 Views

14 Pages

Antagonistic Pharmacological Interaction between Sirtuin Inhibitor Cambinol and Paclitaxel in Triple-Negative Breast Cancer Cell Lines: An Isobolographic Analysis

Anna Wawruszak,
Jarogniew Luszczki,
Estera Okon,
Arkadiusz Czerwonka and
Andrzej Stepulak

Int. J. Mol. Sci.2022, 23(12), 6458;https://doi.org/10.3390/ijms23126458

9 June 2022

Breast cancer (BC) is a heterogeneous disease with different intrinsic subtypes. The most aggressive subtype of BC–triple-negative breast cancer (TNBC) is characterized by high heterogeneity and metastasis rate, poor prognosis and lack of thera...

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Review

8 Citations

4,730 Views

42 Pages

Recent Advances in the Discovery of SIRT1/2 Inhibitors via Computational Methods: A Perspective

Naomi Scarano,
Chiara Brullo,
Francesca Musumeci,
Enrico Millo,
Santina Bruzzone,
Silvia Schenone and
Elena Cichero

Pharmaceuticals2024, 17(5), 601;https://doi.org/10.3390/ph17050601

8 May 2024

Sirtuins (SIRTs) are classified as class III histone deacetylases (HDACs), a family of enzymes that catalyze the removal of acetyl groups from the ε-N-acetyl lysine residues of histone proteins, thus counteracting the activity performed by hi...

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Article

13 Citations

2,676 Views

21 Pages

Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays

Elena Abbotto,
Beatrice Casini,
Francesco Piacente,
Naomi Scarano,
Elena Cerri,
Michele Tonelli,
Cecilia Astigiano,
Enrico Millo,
Laura Sturla and
Santina Bruzzone
+ 1 author

Pharmaceuticals2023, 16(9), 1316;https://doi.org/10.3390/ph16091316

18 September 2023

Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining attention for the treatment of different cancer types, but also to contrast neurodegenerative disease, diabetes, and autoimmune syndromes. In the search for SIRT...

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Article

1 Citations

2,228 Views

20 Pages

Discovery of Novel Thiazole-Based SIRT2 Inhibitors as Anticancer Agents: Molecular Modeling, Chemical Synthesis and Biological Assays

Francesco Piacente,
Giorgia Guccione,
Naomi Scarano,
Dario Lunaccio,
Caterina Miro,
Elena Abbotto,
Annalisa Salis,
Bruno Tasso,
Monica Dentice and
Santina Bruzzone
+ 2 authors

Int. J. Mol. Sci.2024, 25(20), 11084;https://doi.org/10.3390/ijms252011084

15 October 2024

The search and development of effective sirtuin small molecule inhibitors (SIRTIs) continues to draw great attention due to their wide range of pharmacological applications. Based on SIRTs’ involvement in different biological pathways, their li...

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