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Article

3 Citations

1,796 Views

17 Pages

Intrapleural Fibrinolytic Interventions for Retained Hemothoraces in Rabbits

Christian J. De Vera,
Jincy Jacob,
Krishna Sarva,
Sunil Christudas,
Rebekah L. Emerine,
Jon M. Florence,
Oluwaseyi Akiode,
Tanvi V. Gorthy,
Torry A. Tucker and
Karan P. Singh
+ 4 authors

Int. J. Mol. Sci.2024, 25(16), 8778;https://doi.org/10.3390/ijms25168778

12 August 2024

Bleeding within the pleural space may result in persistent clot formation called retained hemothorax (RH). RH is prone to organization, which compromises effective drainage, leading to lung restriction and dyspnea. Intrapleural fibrinolytic therapy i...

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Article

6 Citations

1,787 Views

19 Pages

Fungi Fibrinolytic Compound 1 Plays a Core Role in Modulating Fibrinolysis, Altering Plasma Clot Structure, and Promoting Susceptibility to Lysis

Chunli Gao,
Bin Bao,
Chunling Bao and
Wenhui Wu

Pharmaceutics2023, 15(9), 2320;https://doi.org/10.3390/pharmaceutics15092320

14 September 2023

Fibrin clot structure and function are major determinants of venous and arterial thromboembolic diseases, as well as the key determinants of the efficiency of clot lysis. Studies have revealed that fungi fibrinolytic compound 1 (FGFC1) is a novel mar...

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Review

396 Views

13 Pages

Factor VII-Activating Protease (FSAP) and Its Importance in Hemostasis—Part II: A Link Between FSAP, Blood Coagulation, and Fibrinolysis: A Narrative Review

Iga Schachta,
Ewa Żekanowska,
Jan Styczyński,
Joanna Murawska,
Simona Lattanzi,
Andrea M. Alexandre and
Artur Słomka

Int. J. Mol. Sci.2025, 26(21), 10709;https://doi.org/10.3390/ijms262110709

3 November 2025

As a continuation of Part I on the structure and regulation of factor VII-activating protease (FSAP), this narrative review synthesizes mechanistic, translational, and limited clinical evidence to delineate FSAP’s roles at the interface of coag...

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Article

8 Citations

2,807 Views

14 Pages

A Novel Marine Pyran-Isoindolone Compound Enhances Fibrin Lysis Mediated by Single-Chain Urokinase-Type Plasminogen Activator

Chunli Gao,
Simin Tang,
Haixing Zhang,
Huishu Zhang,
Tian Zhang,
Bin Bao,
Yuping Zhu and
Wenhui Wu

Mar. Drugs2022, 20(8), 495;https://doi.org/10.3390/md20080495

30 July 2022

Fungi fibrinolytic compound 1 (FGFC1) is a rare pyran-isoindolone derivative with fibrinolytic activity. The aim of this study was to further determine the effect of FGFC1 on fibrin clots lysis in vitro. We constructed a fibrinolytic system containin...

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Article

3 Citations

2,571 Views

23 Pages

Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema

Galina Florova,
Christian J. De Vera,
Rebekah L. Emerine,
René A. Girard,
Ali O. Azghani,
Krishna Sarva,
Jincy Jacob,
Danna E. Morris,
Mignote Chamiso and
Steven Idell
+ 1 author

Pharmaceutics2023, 15(5), 1498;https://doi.org/10.3390/pharmaceutics15051498

14 May 2023

The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments...

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