Search Results (333)

The key to metallic fuel development is the fabrication of uranium metal and alloys into fuel forms. U-Nb alloys are one of the best candidates for a metallic fuel alloy with high-temperature strength sufficient to support the core, acceptable nuclear properties, good fabricability, and compatibility with usable coolant media. Melt processing has been a key component of the metallic fuel cycle, and process models require thermophysical parameters at elevated temperatures, particularly above the melting temperatures, regarding which experimental data are scarce, for accurate simulations and process development. By means of ab initio density-functional theory (DFT) quantum molecular dynamics (QMD), we have calculated the main thermophysical parameters—the density, thermal expansion coefficient, specific heat, thermal conductivity, melting temperature, latent heat of fusion, and viscosity—used in the modeling of the U-6 wt.% Nb alloy casting. The melting temperature of the U-6 wt.% Nb alloy at ambient pressure is obtained by means of QMD simulations using the Z-method. The ambient volume change and latent heat of melting of U-6 wt.% Nb are also derived from QMD simulations in conjunction with analytical fitting for the energy and pressure. The thermal conductivity for the solid U-Nb alloy is calculated from the semi-classical Boltzmann transport equation combined with an estimate of the electron relaxation time obtained from DFT simulations. Full article

Cyclone separators remain widely used for gas–solid separation, yet analytical prediction of cut size and pressure drop remains challenging. This study presents an explicit semi-empirical model for the cut size (d₅₀) of reverse-flow cyclones based on the radial particle equation of motion in cylindrical coordinates, with d₅₀ obtained by equating radial migration time and residence time. A closed-form solution is derived in the Stokes regime, whereas non-Stokes behavior is handled numerically through the Schiller–Naumann drag correction. Turbulence is incorporated through a phenomenological correction, and the grade–efficiency curve is represented by a logistic relation. The model was implemented in MATLAB R2025a and applied in a parametric study covering inlet velocity, particle density, cyclone diameter, and gas viscosity. A Euler-type pressure drop relation was included to examine the separation–energy trade-off. Validation on the Kim et al. benchmark using one calibration point per cyclone family and six independent verification cases yielded a mean absolute percentage error of 13.5% and a root mean square error of 0.22 μm for d₅₀; the paired pressure drop check gave a 2.8% mean absolute percentage error. A complementary benchmark based on Wang et al. using 15 cm 1D3D and 2D2D cyclones under actual-air and standard-air conditions further supported the family-calibrated use of the model. A separate scale-up test showed that constant swirl intensity similarity is not transferable across large diameter changes. The formulation provides a transparent reduced-order tool for preliminary design and sensitivity analysis. Full article

To clarify the regulatory mechanism of NLA on tomato plant architecture and fruit quality, wild-type (WT), nla mutant (narrow leaf angle), and NLA overexpression lines (OE1, OE2) were used as materials, and the study was carried out through genetic analysis, phenotypic and quality determination, and gene expression analysis. The results showed that the tomato leaf angle is controlled by a single gene with semi-dominant inheritance. The nla mutant forms a compact plant architecture due to reduced cell volume at the leaf angle. During vegetative growth, it exhibited significantly increased plant height and decreased stem diameter and crown width. During reproductive growth, it showed significantly higher height of the first inflorescence node and a significantly higher number of the first flowering node. The nla mutant maintained a higher SPAD value during the whole growth period. Mutation of NLA had no significant effect on soluble solids content, but significantly increased flavonoid and titratable acid contents. Meanwhile, the compact architecture optimizes plant spatial distribution, and higher flavonoid content improves antioxidant capacity. Molecular mechanism analysis combined with GA quantification showed that the nla mutant exhibited significantly higher contents of bioactive GA₁ and GA₄, which were closely associated with up-regulated expression of GA biosynthetic genes SlGA20ox1 and SlGA20ox2, as well as down-regulated expression of GA catabolic genes SlGA2ox4 and SlGID1.This study provides a theoretical basis for high-photosynthetic-efficiency breeding and high-quality cultivation of tomato. Full article

Marine mucilage events are intensifying in semi-enclosed seas under accelerating climate- and nutrient-driven pressures, yet their ecosystem-level consequences for aquaculture-linked coastal habitats remain insufficiently documented. This study provides an integrated spatiotemporal assessment of water quality, phytoplankton community structure, and biometric responses of Mytilus galloprovincialis during and after the 2025 mucilage outbreak in the Gulf of Erdek (Sea of Marmara, Türkiye). Mucilage accumulation was associated with sharp increases in turbidity, total suspended solids, and particulate organic matter, alongside declines in dissolved oxygen and pH. Phytoplankton assemblages exhibited marked seasonal restructuring: the mucilage period was characterized by the coexistence of mucilage-forming taxa, non-toxic bloomers, and multiple harmful algal bloom (HAB) groups, including DSP- and ASP-related species, whereas post-mucilage conditions were dominated by non-toxic diatoms with substantially reduced HAB representation. The dinoflagellate species representing the May period in terms of abundance were Noctiluca scintillans and Prorocentrum micans; the diatom species were Chaetoceros radiatus, Cylindrotheca closterium, Pseudo-nitzschia pseudodelicatissima, and Thalassiosira rotula; and the coccolithophore was Phaeocystis pouchetii. Mussel biometric analyses revealed biometric indices and condition values markedly below regional historical baselines during the mucilage event, alongside reduced meat yield, followed by pronounced compensatory growth during the post-mucilage period. Our findings demonstrate that mucilage acts as both a physical and biological stressor, driving short-term ecological shifts in phytoplankton diversity and imposing substantial but reversible physiological impacts on mussel stocks. These results underscore the need for continuous biodiversity monitoring frameworks that integrate mucilage dynamics, HAB occurrence, and aquaculture resilience in regions vulnerable to climate-enhanced organic aggregate formation. Full article

Copper anodic slime is often smelted with lead to improve silver and gold recovery, generating a fine lead-rich fly ash that contains notable amounts of selenium and tellurium. Due to its high lead content and sub-micron particle size, this residue poses significant environmental and occupational health risks. This study evaluates sodium carbonate (Na₂CO₃) leaching as an environmentally benign pre-treatment aimed at partially removing selenium and tellurium while stabilizing lead through carbonate formation. The goal is detoxification rather than maximum metal recovery, enabling safer disposal or subsequent recycling. A central composite design (CCD) in Design-Expert software (Version 12) was used to assess the effects of Na₂CO₃ concentration, temperature, solid-to-liquid ratio, and time on selenium and tellurium dissolution. Selenium recovery reached up to 53.9%, while tellurium recovery peaked at approximately 33.9%. Scanning electron microscopy showed the dust to consist mainly of semi-spherical and elongated particles, with lead carbonate forming preferentially on particle surfaces during leaching. Energy-dispersive spectroscopy confirmed conversion of lead sulfate phases to lead carbonate, which increasingly restricted selenium and tellurium dissolution. Kinetic evaluation suggested selenium leaching follows mixed control involving both surface reaction and diffusion through product layers, whereas tellurium dissolution lacked consistent kinetic behavior. Thermodynamic calculations supported the stabilization of lead as cerussite (PbCO₃), indicating improved environmental safety. The overall dissolution trends were successfully represented using an apparent Shrinking Core Model (SCM) based on measurements collected at 20 °C, 60 °C, and 100 °C. Full article

The synergistic utilization of waste plastics and tires in asphalt modification is a highly promising sustainable strategy. However, the differential impacts of distinct plastic molecular architectures on the performance and network evolution of rubber-modified asphalt remain fundamentally unclear. This study systematically investigated the physical, rheological, and microstructural properties of composite asphalts modified with desulfurized rubber powder (DRP) and four representative plastics: polyethylene (PE), styrene–isoprene–styrene (SIS), styrene–ethylene–butylene–styrene (SEBS), and styrene–butadiene–styrene (SBS). Furthermore, the pavement performance of the asphalt mixtures prepared via dry and wet methods was comparatively evaluated. Microstructural and spectroscopic analyses revealed that the composite modification was primarily governed by physical blending and swelling. The non-polar, semi-crystalline PE resulted in severe phase separation and extreme low-temperature brittleness. Conversely, the saturated hydrogenated mid-blocks of SEBS endowed the asphalt with the highest high-temperature rutting resistance but severely compromised its low-temperature stress relaxation. Remarkably, SBS interacted synergistically with DRP to form a highly homogeneous and densely interwoven three-dimensional network, thereby achieving an optimal viscoelastic balance, outstanding storage stability, and superior low-temperature ductility. Pavement performance tests further demonstrated that the wet method significantly outperformed the dry method for block copolymers by facilitating sufficient pre-swelling. Overall, the SBS-DRP composite-modified asphalt prepared via the wet method exhibited the most exceptional and balanced comprehensive pavement performance, providing a robust theoretical foundation for the sustainable and high-value recycling of multi-source solid wastes in paving engineering. Full article

Children are often underserved by adult-oriented oral medicines, leading to off-label use and dosage-form manipulation that may compromise dosing accuracy. This review summarises recent advances in paediatric orodispersible tablets (ODTs), focusing on manufacturing technologies, superdisintegrants, taste masking, and in vitro disintegration testing. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance and a protocol registered with the International Platform of Registered Systematic Review and Meta-analysis Protocols (registration number INPLASY2025110022), we searched PubMed, EMBASE, MEDLINE, Scopus, and Google Scholar for experimental studies on paediatric-relevant ODT formulation and evaluation. Two reviewers screened studies and extracted data on manufacturing methods, excipients, disintegration/dissolution testing, and key outcomes. Risk of bias was assessed using a six-domain framework. Overall, 65 studies met the inclusion criteria for this review. Direct compression was the dominant method, with freeze-drying, sublimation, spray-drying, nanoparticle-in-tablet systems, and semi-solid extrusion/3D printing also reported. Crospovidone, croscarmellose sodium, and sodium starch glycolate were the most common superdisintegrants, while natural and co-processed disintegrants showed promise as cost-effective alternatives. Disintegration was usually assessed using pharmacopoeial methods, with some modified set-ups to better simulate oral conditions. Paediatric ODT development is advancing rapidly. Broader translation requires harmonised disintegration testing, age-stratified acceptability reporting, and GMP-ready workflows, alongside benchmarking of superdisintegrants and attention to dose flexibility, packaging, and affordability. Full article

Dam-break flows over erodible beds represent a complex fluid–solid interaction problem characterized by extreme turbulence and rapid morphological changes. This study investigates the dynamics of such flows over inclined granular beds by integrating an advanced Moving Particle Semi-implicit (MPS) method. To accurately resolve the transition between static and kinetic granular regimes, I introduce a state-dependent tangential friction model that explicitly distinguishes between sticking and sliding conditions based on local force balance. Furthermore, the momentum exchange between the fluid and solid phases is rigorously modeled using the porosity-dependent drag formulation. The numerical results demonstrate a distinct regime shift in energy dissipation: while low-inclination beds (0–$4\%$) promote distributed sediment transport, steep-inclination beds (8–$12\%$) trigger a localized “Shielding Effect”. In this regime, the surge’s horizontal kinetic energy is rapidly converted into vertical potential energy and frictional work, forming a deep sacrificial scour hole that acts as a topographical energy sink. This mechanism effectively mitigates the destructive potential of the surge in downstream areas. The proposed method provides a robust tool for predicting morphological feedback and designing topographical countermeasures for disaster mitigation in hydraulic and coastal environments. Full article

Jojoba oil is a well-established skin-beneficial liquid wax with high value in topical formulations. Bigels, as preferred semi-solid dosage forms, serve as versatile platforms by incorporating hydrogels and oleogels to leverage their advantages and address their limitations. In this study, jojoba oil bigels were developed using sorbitan monostearate (20%, w/w) as an oleogelator and different hydrophilic bases, 1% Carbomer 940, 6% methylcellulose, or 20% Poloxamer 407 gel, with all concentrations expressed relative to the corresponding phase. Nine bigels were obtained by varying hydrogel-to-oleogel ratios (90:10–70:30). They were evaluated in terms of their organoleptic, microstructural, and textural characteristics. Both the hydrogel matrix type and the phase proportion impacted the studied properties. Carbomer bigels displayed the highest spreadability, methylcellulose formulations showed the greatest adhesiveness, and poloxamer systems exhibited maximum firmness and cohesiveness, with a comparatively more homogeneous phase distribution. The increase in oleogel content enhanced firmness and cohesiveness while modulating spreadability and adhesiveness in a hydrogel-dependent manner. Moreover, all designed formulations remained physically stable after centrifugation, but only those containing 80% carbomer gel or 70% or 80% poloxamer gel preserved their mechanical characteristics without significant changes after freeze-thawing. Besides identifying three promising biphasic dermal drug delivery platforms, these findings reinforce the tunability of bigels through the careful component selection. Full article

The growing demand for healthier food options has accelerated the development of innovative fat-replacement strategies in spreadable products. Oleogels are semi-solid systems formed by structuring edible oils. Recently, these systems have emerged as a promising solution for reducing saturated fat content without compromising product quality, texture, or sensory attributes. A systematic review was conducted following the PRISMA 2020 protocol, supplemented by a bibliometric analysis. Research was identified through searches in Web of Science, Scopus, Wiley, Springer, MDPI, and Google Scholar for studies published between 2020 and 2024. Inclusion criteria focused on original research articles in English involving food-sector applications of oleogels and aerogels in sweet spreads. Study quality and risk of bias were assessed by two independent reviewers based on methodological relevance and data integrity. Results were synthesized through a narrative approach and bibliometric mapping. After screening 490 records, 34 original research articles were included. Bibliometric data highlighted a clear trend shifting from foundational lipid structuring research in 2020 toward complex, product-specific functional applications by 2024. Overall, the results suggest that these structured systems are viable replacements for traditional saturated fats, providing comparable spreadability and stability. Funding: This work was supported by the Croatian Science Foundation under the project IP-2022-10-1960. This systematic review was not registered in a public database. Full article

Background/Objectives: Manual preparation of semisolid formulations (creams, ointments, gels) is prone to variability in mixing energy and time, which may compromise uniform API distribution. This study aimed to evaluate an Electronic Mortar and Pestle (EMP; Unguator™) as a standardized compounding tool, with objectives to: (i) validate stability-indicating UHPLC methods; (ii) assess content uniformity across jar strata; (iii) quantify the impact of mixing time and rotation speed via design of experiments (DOE); and (iv) verify cleaning effectiveness and cross-contamination risk. Methods: Five representative formulations were compounded: urea 40%, clobetasol 0.05%, diclofenac 2.5% in hyaluronic acid 3% gel, urea 10% + salicylic acid 1%, and hydroquinone 5%. UHPLC methods were validated per ICH Q2(R2) and stress-tested under acid, base, oxidative, thermal, and UV conditions. Homogeneity was assessed by stratified sampling (top/middle/bottom). A 3² factorial DOE (time: 2/6/10 min; speed: 600/1500/2400 rpm) modeled effects on % label claim and RSD. Cleaning validation employed hydroquinone as a tracer, with swab sampling pre-/post-use and post-sanitization analyzed by HPLC. Results: All UHPLC methods met specificity, linearity, precision, accuracy, and sensitivity criteria and were stability-indicating (Rs ≥ 1.5). Formulations achieved 90–110% label claim with strata CV ≤ 5%. DOE revealed speed as the dominant factor for clobetasol, urea, and diclofenac, while time was more influential for salicylic acid; gels exhibited curvature, indicating diminishing returns at high rpm. Model-predicted optima were implementable on the Unguator™ with minor rounding of rpm/time. Cleaning validation confirmed post-sanitization residues below LOQ and <10 ppm acceptance. Conclusions: The Unguator™ provides a practical, parameter-controlled route for compounding pharmacies to standardize semisolid preparations, achieving reproducible layer-to-layer content uniformity within predefined criteria under the evaluated conditions through programmable set-points and validated cycles. DOE-derived rpm–time relationships define an operational design space within the studied ranges and support selection of implementable device settings and set-points. Importantly, the DOE-derived “optima” in this study are optimized for assay-based content uniformity (mean % label claim and strata variability). Cleaning validation supports a closed, low-cross-contamination workflow, facilitating consistent routines for both routine and complex formulations. Overall, the work implements selected QbD elements (QTPP—Quality Target Product Profile; CQA—Critical Quality Attribute definition; CPP—Critical Process Parameter identification; operational design space; and a proposed control strategy) and should be viewed as a step toward broader lifecycle QbD implementation in compounding. Full article

This study aimed at developing in vitro propagation methods for Crocus sativus L., focusing on the effectiveness of temporary immersion systems (TIS) or bioreactors as an alternative, cost-efficient technique for the large-scale production of saffron corms. The effects of the culture system and cross-cutting on saffron propagation were evaluated. Saffron shoots were cultured in TIS and compared with shoots produced using a conventional semi-solid tissue culture system (SS). The recipient material for automated temporary immersion used in this study was the SETIS™ bioreactor. The growth parameters measured for in vitro culture were the number of neo-formed shoots, shoot height, and the number and size of corms. Based on the present detailed study, the highest shoot multiplication rate (9.1 shoots/explant with 7.2 cm of shoot height) was achieved in the TIS system after shoot cross-cutting, while the lowest multiplication rates were obtained in the semi-solid system (1 shoot/explant with 14.8 cm long shoots). Furthermore, the highest corm formation was obtained in the TIS system, with an average of four corms per explant, with a larger corm weight (10.90 g) and diameter (21.78 mm). These findings highlighted for the first time the efficiency of the bioreactor system combined with cross-cutting of the shoot for efficient and scalable saffron corm propagation, thus making a valuable contribution to sustainable cultivation and conservation strategies while meeting the growing demand for this spice. Full article

Incorporating hydrophobic flavonoids such as naringenin into food systems is challenging due to their poor water solubility and instability. Effective delivery systems are essential to improve solubility, dispersibility, and controlled release during digestion. This study developed a food-grade encapsulation system using basil seed gum water-soluble extract (BSG-WSE) combined with proteins, sodium caseinate (NaCas) and whey protein isolate (WPI), via pH-driven and mild heat treatments in aqueous media, without the use of organic solvents, to ensure safety and sustainability. BSG-WSE and NaCas were tested at mass ratios of 1:1, 1:3, and 1:5 under pH conditions of 4, 5, and 7, followed by heat treatments at 60 °C or 80 °C for 30 min. The total biopolymer concentrations were 0.15%, 0.3%, and 0.45% (w/v). The most stable colloidal system was obtained at a 1:1 ratio, pH 4, and 60 °C, which was further evaluated for two additional flavonoids (rutin and quercetin) and with WPI as an alternative protein source. The highest loading capacity (11.18 ± 0.17%) and encapsulation efficiency (72.50 ± 0.85%) were achieved for naringenin under these conditions. Quercetin exhibited superior performance, with a loading capacity of 14.1 ± 3.12% and an encapsulation efficiency of 94.36 ± 5.81%, indicating a stronger affinity for the delivery system. WPI showed lower encapsulation efficiency than NaCas. Ternary systems (BSG-WSE, NaCas, and naringenin) formed under different pH and heat treatments displayed distinct morphologies and interactions. The pH 4 system demonstrated good dispersion and pH-responsive release of naringenin, highlighting its potential as a delivery vehicle for hydrophobic flavonoids. BSG-WSE significantly improved the stability of protein-based complexes formed via pH-driven assembly. Physicochemical characterization, rheological analysis, and release studies suggest that this system is particularly suitable for semi-solid food products such as yogurt or emulsions, supporting its application in functional food development. Full article

Agricultural non-point source pollution (ANPSP) represents a major threat to water quality, yet its spatiotemporal dynamics in arid and semi-arid regions remain poorly quantified. This study establishes an integrated assessment framework to analyze the spatiotemporal patterns and driving mechanisms of ANPSP in Inner Mongolia, China, from 2002 to 2023. Using a combination of inventory analysis, pollution load equivalence assessment, and the Tapio decoupling model, we systematically examined the evolution of four pollution sources—chemical fertilizers, livestock breeding, agricultural solid waste, and rural domestic discharge—across 12 administrative regions. These methods were sequentially applied to quantify loads, standardize impacts, and evaluate the economy–environment relationship, forming a coherent analytical chain. Key results indicate the following: (1) Pollutant loads increased consistently over the study period, with chemical oxygen demand (COD), total nitrogen (TN), and total phosphorus (TP) rising by 24.21%, 31.67%, and 31.14%, respectively, largely driven by livestock sector expansion. (2) Spatial distribution was highly heterogeneous, with Tongliao, Chifeng, and Hulunbuir contributing 50.58–58.31% of total emissions, in contrast to minimal impacts in western regions. (3) Decoupling analysis indicated variable environment–economy relations, where fertilizer use and grain output reached strong decoupling in 2010–2011 and 2018–2019, whereas livestock pollution exhibited more unstable decoupling trajectories. A cluster-derived risk zoning scheme identified Bayannur as the only high-risk area and highlighted the need for tailored management approaches in medium- and low-risk zones. This study offers a scientific foundation for targeted ANPSP mitigation and sustainable agricultural strategy formulation in ecologically vulnerable areas. Full article

Vegetation concrete is a composite material integrating plant growth and concrete technology. In this study, solid waste materials (phosphogypsum and recycled aggregates) were utilized to prepare vegetation concrete. Semi-hydrated phosphogypsum (HPG) was used to replace ordinary Portland cement as a cementitious material in a gradient manner, while recycled coarse aggregates (RCAs) fully replaced natural crushed stone. The basic properties of phosphogypsum–recycled aggregate-based vegetation concrete were analyzed, and X-ray diffraction (XRD) and scanning electron microscopy (SEM) were employed to characterize the hydration products of vegetation concrete with different mix ratios. The results indicated that replacing cement with HPG exerted a significant alkali-reducing effect and provided favorable cementitious strength. When the porosity was 24% and the HPG content was 50%, the vegetation concrete exhibited optimal performance: the 28-day compressive strength reached 12.3 MPa, and the pH value was 9.7. Recycled aggregates had a minimal impact on strength. When 0.5% sodium gluconate was added as a retarder, the initial setting time was 97 min and the final setting time was 192 min, which met construction requirements with little influence on later-stage strength. Microscopic analysis revealed that the early strength (3d–7d) of vegetation concrete was primarily contributed by CaSO₄·2H₂O crystals (the hydration product of HPG), while the later-stage strength was supplemented by C-S-H (the hydration product of cement). Planting tests showed that Tall Fescue formed a lawn within 30 days; at 60 days, the plant height was 18 cm and the root length was 6–8 cm. Some roots grew along the sidewalls of concrete pores and penetrated the 5 cm thick vegetation concrete slab, demonstrating good growth status. Full article