Search Results (2,038)

This article focuses on the fire safety risks associated with conventional glass–aluminum façades—with a particular focus on stick and unitized curtain walling systems—providing an overview of possible fire spread mechanisms, considering the role of the curtain wall in maintaining compartmentation at the spandrel zone. First, it analyzes some of the relevant requirements of different European building regulations. Then, it provides a test evidence-based critical analysis of the gaps and loopholes in the relevant fire resistance standard for partial curtain wall configurations (EN 1364-4), where the evaluation of the propagation within the façade system is not necessarily considered in the fire-resistant spandrel zone. Finally, it presents a proposal for addressing these gaps in the form of a theoretical concept for a new test configuration and additional assessment criteria. This is followed by an initial experimental analysis of the concept. The standard testing campaign showed that temperature rise in mullions can exceed 180 °C after 30 min if limiting measures are not considered in the façade design. However, this can be only detected if framing is in the non-exposed area of the sample, being part of the evaluation surface. Meanwhile, differences are detected between the results from standard and new assessment criteria in the new configuration proposed, including a more rapid temperature rise for framing elements (207 K in a second level mullion at minute 90) than for the common non-exposed assessment surface of the sample (172 K at the same time) in cases where cavities are not protected. Accordingly, the proposed configuration successfully detected vertical temperature transfer within mullions, which can remain undetected in standard EN 1364-4 tests, highlighting the potential for fire spread even in EI120-rated assemblies. Full article

Accurately identifying driver fatigue in complex driving environments plays a crucial role in road traffic safety. To address the challenge of reduced fatigue detection accuracy in complex cabin environments caused by lighting variations, we propose YOLO-FDCL, a novel algorithm specifically designed for driver fatigue detection under complex lighting conditions. This algorithm introduces MobileNetV4 into the backbone network to enhance the model’s ability to extract fatigue-related features in complex driving environments while reducing the model’s parameter size. Additionally, by incorporating the concept of structural re-parameterization, RepFPN is introduced into the neck section of the algorithm to strengthen the network’s multi-scale feature fusion capabilities, further improving the model’s detection performance. Experimental results show that on the YAWDD dataset, compared to the baseline YOLOv8-S, precision increased from 97.4% to 98.8%, recall improved from 96.3% to 97.5%, mAP@0.5 increased from 98.0% to 98.8%, and mAP@0.5:0.95 increased from 92.4% to 94.2%. This algorithm has made significant progress in the task of fatigue detection under complex lighting conditions. At the same time, this model shows outstanding performance on our self-developed Complex Lighting Driving Fatigue Dataset (CLDFD), with precision and recall improving by 2.8% and 2.2%, respectively, and improvements of 3.1% and 3.6% in mAP@0.5 and mAP@0.5:0.95 compared to the baseline model, respectively. Full article

Background: The rationale for strict fluid fasting for pediatric and adult patients has been questioned recently. Point-of-care tools for the evaluation of gastric content have evolved over time, often using gastric ultrasound. Usually, the gastric antral cross-sectional area (CSA) is determined. A liberal fluid fasting regimen, that is, ingestion of liquid fluids until the call for theatre, does not delay gastric emptying compared to midnight fasting, as evaluated with gastric ultrasound. Anesthesia is safe, and no adverse events result from a liberal regimen. Methods: The ethics committee of LMU Munich approved the study (21-0903). Liberal fluid fasting in a geriatric orthopedic surgery department (LFFgertrud) is a sub-study within a project investigating perioperative neurocognitive disorders (Study Registration: DRKS00026801). After obtaining informed consent from 134 geriatric patients 70 years or older, we investigated the gastric antral cross-sectional area (CSA) prior to and postimplementation of liberal fluid management, respectively. Results: After the implementation of liberal fluid fasting, fasting times for solid food and liquids decreased from 8.8 (±5.5) to 1.8 (±1.8) hours (p < 0.0001). In 39 patients where CSA was obtained, a slight increase in fluid was encountered. No critical amount of gastric content was observed, and no adverse events occurred. Conclusions: A liberal fluid fasting concept was safe even for comorbid elderly patients in orthopedic surgery. Applying a gastric ultrasound may be helpful to increase safety. According to the incidence of complications encountered in our study, it seems indispensable. Full article

This article presents the design, development, and evaluation of an AI-based assistant tailored to support users in the application of the Specific Operations Risk Assessment (SORA) methodology for unmanned aircraft systems. Built on a customized language model, the assistant was trained using system-level instructions with the goal of translating complex regulatory concepts into clear and actionable guidance. The approach combines structured definitions, contextualized examples, constrained response behavior, and references to authoritative sources such as JARUS and EASA. Rather than substituting expert or regulatory roles, the assistant provides process-oriented support, helping users understand and complete the various stages of risk assessment. The model’s effectiveness is illustrated through practical interaction scenarios, demonstrating its value across educational, operational, and advisory use cases, and its potential to contribute to the digital transformation of safety and compliance processes in the drone ecosystem. Full article

This concept paper outlines an implementation strategy for a mandatory training programme using the ADDIE instructional design model for delivery to nurses and other health professionals in an interprofessional education (IPE) environment). Background: Competence in Basic Life Support (BLS) is a lifesaving requirement for health professionals in clinical settings to ensure patient safety and accreditation outcomes. It is essential that health professionals are supported in attending mandatory training, including BLS. To inform learning and teaching strategies, it is useful to apply theoretical perspectives to the development of mandatory staff training methods. However, various training models exist, and few are grounded in instructional design theory to the unique environment for BLS in IPE. Method: A theory-based implementation strategy is outlined for a mandatory interprofessional training programme including BLS, using the ADDIE model to enhance patient outcomes. ADDIE is an instructional design framework comprising five elements: Assess, Design, Develop, Implement and Evaluate; describing a learning methodology that can be readily applied to mandatory training in IPE. Results: Through its iterative capability, the ADDIE model promotes learner needs and rapid acquisition of clinical skills that improve training accessibility. The strategy can equip educators with teaching skills based on a robust theoretical model, with potential to promote nursing and health professional attendance for mandatory training. Conclusions: Mandatory health professional training that addresses a theory informed strategy framed by the ADDIE model can support interprofessional collaboration and consistent competency across healthcare teams. This strategy has potential to contribute by demonstrating how instructional design can be operationalised to improve the effectiveness and engaging approach to BLS training and education to the unique dynamics of an interprofessional environment. Full article

Early evacuation during bushfires remains the safest strategy; however, in many realistic scenarios, timely evacuation is challenging, making safe sheltering a last-resort option to reduce risk compared to late evacuation attempts. However, most Australian homes in bushfire-prone areas are neither designed nor retrofitted to provide adequate protection against extreme bushfires, raising safety concerns. This study addresses this gap by investigating the concept of retrofitting a part of the residential buildings as attached safe rooms for sheltering and protection of valuables, providing a potential last-resort solution for bushfire-prone communities. Numerical simulations were conducted using the Fire Dynamics Simulator to assess heat transfer and internal temperature conditions in a representative residential building under bushfire exposure conditions. The study investigated the impact of the placement of the safe room relative to the fire front direction, failure of vulnerable building components, and the effectiveness of steel shutters in response to internal temperatures. The results showed that the strategic placement of safe rooms inside the building, along with adequate protective measures for windows, can substantially reduce internal temperatures. The findings emphasised the importance of maintaining the integrity of openings and the external building envelope, demonstrating the potential of retrofitted attached safe rooms as a last-resort solution for existing residential buildings in bushfire-prone areas where the entire building was not constructed to withstand bushfire conditions. Full article

Creating a comfortable microclimate in the premises of buildings is currently becoming one of the priorities in the field of architecture, construction and engineering systems. The increased attention from the scientific community to this topic is due not only to the desire to ensure healthy and favorable conditions for human life but also to the need for the rational use of energy resources. This area is becoming particularly relevant in the context of global challenges related to climate change, rising energy costs and increased environmental requirements. Practice shows that any technical solutions to ensure comfortable temperature, humidity and air exchange in rooms should be closely linked to the concept of energy efficiency. This allows one not only to reduce operating costs but also to significantly reduce greenhouse gas emissions, thereby contributing to sustainable development and environmental safety. In this connection, this study presents a parametric assessment of the influence of climatic and geometric factors on the aerodynamic characteristics of the air cavity, which affect the heat exchange process in the ventilated layer of curtain wall systems. The assessment was carried out using a combined analytical calculation method that provides averaged thermophysical parameters, such as mean air velocity ($V_s$), average internal surface temperature ($t_{in.s}^{av}$), and convective heat transfer coefficient (${\alpha }_s$) within the air cavity. This study resulted in empirical average values, demonstrating that the air velocity within the cavity significantly depends on atmospheric pressure and façade height difference. For instance, a 10-fold increase in façade height leads to a 4.4-fold increase in air velocity. Furthermore, a three-fold variation in local resistance coefficients results in up to a two-fold change in airflow velocity. The cavity thickness, depending on atmospheric pressure, was also found to affect airflow velocity by up to 25%. Similar patterns were observed under ambient temperatures of +20 °C, +30 °C, and +40 °C. The analysis confirmed that airflow velocity is directly affected by cavity height, while the impact of solar radiation is negligible. However, based on the outcomes of the analytical model, it was concluded that the method does not adequately account for the effects of solar radiation and vertical temperature gradients on airflow within ventilated façades. This highlights the need for further full-scale experimental investigations under hot climate conditions in South Kazakhstan. The findings are expected to be applicable internationally to regions with comparable climatic characteristics. Ultimately, a correct understanding of thermophysical processes in such structures will support the advancement of trends such as Lightweight Design, Functionally Graded Design, and Value Engineering in the development of curtain wall systems, through the optimized selection of façade configurations, accounting for temperature loads under specific climatic and design conditions. Full article

Biodegradable magnesium alloys have emerged as promising alternatives to permanent metallic implants due to their unique combination of mechanical compatibility with bone and complete resorption, addressing the persistent issues of stress shielding and secondary removal surgeries. This review critically examines the historical development of magnesium-based biomaterials, highlighting advances in alloy design, manufacturing processes, and surface engineering that now enable tailored degradation and improved clinical performance. Drawing on recent clinical and preclinical studies, we summarize improvements in corrosion resistance, mechanical properties, and biocompatibility that have supported the clinical translation of magnesium alloys across a variety of orthopedic and emerging medical applications. However, challenges remain, including unpredictable in vivo degradation kinetics, limited long-term safety data, lack of standardized testing protocols, and ongoing regulatory uncertainties. We conclude that while magnesium-based biomaterials have advanced from experimental concepts to clinically validated solutions, further progress in personalized degradation control, real-time monitoring, and harmonized regulatory frameworks is needed to fully realize their transformative clinical potential. Full article

Air traffic controllers (ATCOs) make a significant contribution to ensuring flight safety, making this profession a highly stressful job globally. Job demands–resources (JDR) theory proposes a health impairment process stemming from job demand (complexity) to mental workload, which causes job stress, resulting in compromised flight safety. This vicious cycle is evident among ATCOs and is recognized as an unsustainable management practice. To curb this process, we propose intra-functional flexibility as a conditional factor. Intra-functional flexibility refers to the flexibility in the reallocation and coordination of resources among team members to help in urgent times. This is a relatively new concept and is yet to be empirically tested in the ATCO context. ATCOs work in a dynamic environment filled with sudden surges of urgent jobs to be handled within short time limits. Intra-functional flexibility allows standby crews to be called to ease these tensions when needed. To ascertain the role of intra-functional flexibility in mitigating health impairment among ATCOs, a questionnaire was administered to 324 ATCOs distributed across Saudi Arabia. Partial Least Squares Structural Equation Modeling (PLS-SEM) analysis exhibited two critical findings: First, the study revealed the prevalence of a vicious cycle of health impairment among Saudi ATCOs, whereby job complexity leads to increased mental workload, resulting in elevated levels of job stress. Secondly, the presence of intra-functional flexibility weakened this vicious cycle by mitigating the influence exerted by mental workload on job stress. That is, the mediation-moderated model proposed in this study provides empirical evidence supporting the applicability of intra-functional flexibility in mitigating the dire suffering of ATCOs. This study discusses limitations and future research directions in the end. Full article

Cancer treatment has undergone a paradigm shift following the introduction of novel cancer treatment approaches that involve the host’s immune system in fighting established tumors. This new concept aids the immune system in identifying, attacking, and killing the tumor cells. However, although some encouraging results were observed clinically, this approach has its own limitations. For example, the benefits of certain anticancer drugs were only observed in some patients, off-target effects, immune evasion, and poor pharmacokinetics. Recently, several advancements have been made with the understanding and development of tumor-targeted drug delivery systems, which combine both effectiveness and patients’ safety during cancer treatment. In this review, we will focus on the latest progress in targeted drug delivery, particularly applying nanoparticles, liposomes, exosomes, and Wharton’s jelly-derived macrovesicles as immune cell enhancers, as well as overcoming therapeutic resistance. We also characterize major current problems, such as the biocompatibility and scalability of the delivered engineering systems, as well as the required regulations. Lastly, we will show some examples of effective approaches to resolve these issues for more efficient cancer therapy. The importance of this article lies in bridging two sides in a single framework perspective: the novel implementation of unique delivery systems and the latest advances in the field of cancer immunotherapy. Thus, this provides better insights for the future of cancer treatment. Full article

Stem cells, unspecialized cells with regenerative and differentiation capabilities, hold immense potential in regenerative medicine, exemplified by hematopoietic stem cell transplantation. However, their clinical application faces significant limitations, including their tumorigenic risk due to uncontrolled proliferation and cellular heterogeneity. This review explores how synthetic biology, an interdisciplinary approach combining engineering and biology, offers promising solutions to these challenges. It discusses the concepts, toolkit, and advantages of synthetic biology, focusing on the design and integration of genetic circuits to program stem cell differentiation and engineer safety mechanisms like inducible suicide switches. This review comprehensively examines recent advancements in synthetic biology applications for stem cell engineering, including programmable differentiation circuits, cell reprogramming strategies, and therapeutic cell engineering approaches. We highlight specific examples of genetic circuits that have been successfully implemented in various stem cell types, from embryonic stem cells to induced pluripotent stem cells, demonstrating their potential for clinical translation. Despite these advancements, the integration of synthetic biology with mammalian cells remains complex, necessitating further research, standardized datasets, open access repositories, and interdisciplinary collaborations to build a robust framework for predicting and managing this complexity. Full article

The presence of people has a complex relationship with public safety—while it is often associated with increased natural surveillance, it can also attract specific types of crime under certain urban conditions. This exploratory study examines this dual relationship by integrating Jane Jacobs’s urban theories and the principles derived from them in Quito, Ecuador. Anchored in Jacobs’s concept of “eyes on the street,” this research assesses four morphological dimensions—density, land use mixture, contact opportunity, and accessibility through nine specific indicators. A binary logistic regression model is used to examine how these features relate to the incidence of street robberies against individuals. The findings indicate that urban form characteristics that foster “eyes on the street”—such as higher population density and a mix of commercial and residential uses—show statistically significant associations with lower rates of street robbery. However, other indicators of “eyes on the street”—such as larger block sizes, proximity to public transport stations, greater street lighting, and a higher balance between residential and non-residential land uses—correlate with increased crime rates. Some indicators, such as population density, block size, and distance to public transport stations, show statistically significant relationships, though the practical effect size compared to residential/non-residential balance, commercial and facility mix, and street lighting is modest. These results underscore the importance of contextualizing Jacobs’s frameworks and offer a novel contribution to the literature by empirically testing morphological indicators promoting the presence of people against actual crime data. Full article

Wildlife strikes in aviation are among the most reported safety incidents. As such, strikes have become the fundamental unit of understanding of the risk posed by wildlife. However, the management of wildlife risks to aviation has shifted to a hazard management philosophy. This literature review examines the argument that current wildlife strike reporting requirements are inadequate for modern wildlife hazard management techniques. This review utilised bibliometric analysis software to identify relevant academic research sourced from the Web of Science, as well as industry materials, to compile a final catalogue (n = 542). Further filtering revealed a limited set of relevant papers (n = 42) and even fewer papers that addressed the above question. Analysis of these papers and the wider catalogue noted limitations in current reporting requirements as they relate to hazard and risk management concepts. This analysis was supplemented with a review of international standards and relevant national requirements, concluding that while academics and industry have adopted systematic safety and hazard management techniques, and international guidance material has kept pace, international standards, the foundation for many national reporting systems, remain decades behind. This paper proposes the use of robust consensus-building methodologies, such as the Delphi technique, in the industry as a means of streamlining and supporting international standards development. Full article

The research presented in this paper focuses on the utilization of 3D printing technology in the design and manufacture of a prosthetic hand, equipped with a digit replicator. The subject of this study was a young man who had undergone the amputation of two fingers on his right hand. The electronic control of the movement of the finger copy was developed using Arduino language. A concept and outline drawings were developed in ProCreate. Three-dimensional scan of the hand and forearm was made using an EinScan PRO HD SHINING 3D scanner. Using CAD software—Autodesk Inventor and Autodesk Meshmixer, the prosthesis was designed. Printing was carried out on a 3D printer of the i3 MK3 and MK3+ series using a PLA (polylactic acid) filament. It was determined that PLA is an optimal material for printing, as it is considered to be safe for future patients’ skin. Work on the electronic circuitry started in Autodesk TinkerCad simulation software, allowing the code to be verified and ensuring the safety of the control system. The prosthesis’s design demonstrates the potential to reach as many people in need as possible by using readily available, low-cost, and easy-to-use components. Full article

Slope stability analysis is conventionally performed using the strength reduction method with the proportional reduction in shear strength parameters. However, during actual slope failure processes, the attenuation characteristics of rock mass cohesion ($c$) and internal friction angle ($\phi$) are often inconsistent, and their reduction paths exhibit clear nonlinearity. Relying solely on proportional reduction paths to calculate safety factors may therefore lack scientific rigor and fail to reflect true slope behavior. To address this limitation, this study proposes a novel approach that considers the non-proportional reduction of $c$ and $\phi$, without dependence on predefined reduction paths. The method begins with an analysis of slope stability states based on energy dissipation theory. A Bayesian Gaussian Mixture Model (BGMM) is employed for intelligent interpretation of the dissipated energy data, and, combined with energy mutation theory, is used to identify instability states under various reduction parameter combinations. To compute the safety factor, the concept of a “reference slope” is introduced. This reference slope represents the state at which the slope reaches limit equilibrium under strength reduction. The safety factor is then defined as the ratio of the shear strength of the target analyzed slope to that of the reference slope, providing a physically meaningful and interpretable safety index. Compared with traditional proportional reduction methods, the proposed approach offers more accurate estimation of safety factors, demonstrates superior sensitivity in identifying critical slopes, and significantly improves the reliability and precision of slope stability assessments. These advantages contribute to enhanced safety management and risk control in slope engineering practice. Full article