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Keywords = pyrroloquinoline alkaloids

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24 pages, 3786 KiB  
Review
Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas
by Amr El-Demerdash, Atanas G. Atanasov, Anupam Bishayee, Mamdouh Abdel-Mogib, John N. A. Hooper and Ali Al-Mourabit
Nutrients 2018, 10(1), 33; https://doi.org/10.3390/nu10010033 - 2 Jan 2018
Cited by 27 | Viewed by 7742
Abstract
Pyrroloquinoline and guanidine-derived alkaloids present distinct groups of marine secondary metabolites with structural diversity that displayed potentialities in biological research. A considerable number of these molecular architectures had been recorded from marine sponges belonging to different marine genera, including Batzella, Crambe, [...] Read more.
Pyrroloquinoline and guanidine-derived alkaloids present distinct groups of marine secondary metabolites with structural diversity that displayed potentialities in biological research. A considerable number of these molecular architectures had been recorded from marine sponges belonging to different marine genera, including Batzella, Crambe, Monanchora, Clathria, Ptilocaulis and New Caledonian starfishes Fromia monilis and Celerina heffernani. In this review, we aim to comprehensively cover the chemodiversity and the bioactivities landmarks centered around the chemical constituents exclusively isolated from these three marine genera including Batzella, Crambe and Monanchora over the period 1981–2017, paying a special attention to the polycyclic guanidinic compounds and their proposed biomimetic landmarks. It is concluded that these marine sponge genera represent a rich source of novel compounds with potential applications for cancer and other therapeutic areas. Full article
(This article belongs to the Special Issue Natural Products for Cancer Prevention and Therapy)
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